Degradation kinetics of etoposide in aqueous solution

Beijnen, Jos H.; Holthuis, J.J.M.; Kerkdijk, H.G.; Houwen, O.A.G.J. van der; Paalman, A. C. A.; Bult, A.; Underberg, W.J.M.

doi:10.1016/0378-5173(88)90149-4

Cited by 37 publications

(13 citation statements)

References 15 publications

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“…Controlled release of etoposide (half life of ~4 hr [24]) has been demonstrated with PLGA and PCL microspheres designed for intramuscular depot administration (~45 μm) [21]. With low etoposide loading (<5%), the drug could be released over a period spanning several weeks.…”

Section: Resultsmentioning

confidence: 99%

Enhanced efficacy of local etoposide delivery by poly(ether-anhydride) particles against small cell lung cancer in vivo

Tang

Watkins

2010

Biomaterials

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Drug carrier particles composed of poly(ethylene glycol)-co-poly(sebacic acid) (PEG-PSA) have been shown capable of efficient aerosolization into model lungs and the ability to rapidly penetrate human mucus. Here, we develop PEG-PSA particles (Etop/PEG-PSA) that encapsulate up to 40% etoposide by weight in a one step process, release it continuously for 6 days in vitro, and maintain its cytotoxic activity against a human lung tumor cell line in vitro. We further show that Etop/PEG-PSA injected intratumorally effectively suppress human lung tumor growth in a xenograft mouse model, with 100% survival after 31 days. In contrast, 0% survival was observed by day 24 in animals that received free etoposide (either intratumoral or intraperitoneal administration) or placebo particles intratumorally. These findings support PEG-PSA as a drug delivery platform for improved local therapy of cancer.

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Section: Resultsmentioning

confidence: 99%

Enhanced efficacy of local etoposide delivery by poly(ether-anhydride) particles against small cell lung cancer in vivo

Tang

Watkins

2010

Biomaterials

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“…For a correct drug content estimation, sensitive, simple, and cost effective methods are needed, including UV, visible, fluorescence, and high performance liquid chromatography. For the estimation of ETO, the most reported methods are based on liquid chromatographic technique utilizing UV [69,70], fluorescence [71], and electrochemical [72] detectors or the HPLC method utilizing gradient Usually, 1 H NMR analysis is also useful for obtaining quantitative evaluations and determining DL%. In this case, in order to quantify the ETO content in CPX 5, integrals related to very different numbers of proton atoms should have been compared, committing substantial errors.…”

Section: Quantitative Investigations By Uv Spectrophotometric Analysimentioning

confidence: 99%

Polyester-Based Dendrimer Nanoparticles Combined with Etoposide Have an Improved Cytotoxic and Pro-Oxidant Effect on Human Neuroblastoma Cells

2020

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Etoposide (ETO) is a cytotoxic drug that exerts its effect by increasing reactive oxygen species (ROS) production. Although ETO is widely used, fast metabolism, poor solubility, systemic toxicity, and multi-drug resistance induction all limit its administration dosage and its therapeutic efficiency. In order to address these issues, a biodegradable dendrimer was prepared for entrapping and protecting ETO and for enhancing its solubility and effectiveness. The achieved dendrimer complex with ETO (CPX 5) showed the typical properties of a well-functioning delivery system, i.e., nanospherical morphology (70 nm), optimal Z-potential (−45 mV), good drug loading (37%), very satisfying entrapment efficiency (53%), and a remarkably improved solubility in biocompatible solvents. In regards to its cytotoxic activity, CPX 5 was tested on neuroblastoma (NB) cells with very promising results. In fact, the dendrimer scaffold and ETO are able to exert per se a cytotoxic and pro-oxidant activity on human NB cells. When CPX 5 is combined with ETO, it shows a synergistic action, slowly releasing the drug over time and significantly improving and protracting bioactivity. On the basis of these findings, the prepared ETO reservoir represents a novel biodegradable and promising device for the delivery of ETO into NB cells.

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“…It has been used in the treatment of a variety of malignancies like malignant lymphoma, brain stem gliomas, small cell lung carcinoma, stomach cancer, and ovarian cancer. Among them, etoposide, a semisynthetic epipodophyllotoxin derivative, is a first choice drug for the treatment of the above mentioned diseases 1–3. However, its degradation at pH 1.3; poor water solubility and slow intrinsic dissolution rate make it quite challenging to prepare optimal formulation from it 4, 5.…”

Section: Introductionmentioning

confidence: 99%

A novel approach to prepare etoposide‐loaded poly(N‐vinyl caprolactam‐co‐methylmethacrylate) copolymeric nanoparticles and their controlled release studies

Shah

Pal

Gude

et al. 2012

J of Applied Polymer Sci

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A series of copolymeric nanoparticles of methyl methacrylate and N-vinylcaprolactam were synthesized from microemulsions containing sodium dodecyl sulfate. Etoposide as a model drug was loaded in nanoparticles during in situ polymerization. Stable nanolatex were produced and characterized for size and shape by dynamic light scattering (DLS) and transmission electron microscopy. Particles were found to be spherical in nature with size less than 50 nm. Structural characterization of copolymers was done by infrared and nuclear magnetic resonance spectroscopy. Differential scanning calorimetery (DSC) and X-ray diffractometry (XRD) techniques were used to evaluate molecular level interaction of etoposide with nanoparticles. Drug encapsulation efficiency was determined by ultraviolet (UV) spectrometry and found to be 35-67%. DSC, XRD, and UV data suggested the molecular level dispersion of drug in the nanoparticles. In vitro release studies and in vitro cytotoxicity showed prolonged and controlled release of etoposide from nanoparticles along with IC 50 values of nanoparticles in the range of 0.01-0.1 mg/mL.

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Degradation kinetics of etoposide in aqueous solution

Cited by 37 publications

References 15 publications

Enhanced efficacy of local etoposide delivery by poly(ether-anhydride) particles against small cell lung cancer in vivo

Enhanced efficacy of local etoposide delivery by poly(ether-anhydride) particles against small cell lung cancer in vivo

Polyester-Based Dendrimer Nanoparticles Combined with Etoposide Have an Improved Cytotoxic and Pro-Oxidant Effect on Human Neuroblastoma Cells

A novel approach to prepare etoposide‐loaded poly(N‐vinyl caprolactam‐co‐methylmethacrylate) copolymeric nanoparticles and their controlled release studies

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