Degradation mechanism and kinetic studies of a novel anticancer agent, AG2034

Oxidative degradation of pharmaceuticals: Theory, mechanisms and inhibition

“…The relative yields of these processes depend on the nature of the solvent (protic versus aprotic) and the lability of the CH bond in the α‐position to the sulfur. Prominent examples for thioether oxidation in drugs are found for phenothiazines (vide supra) and, recently, the anticancer agent AG2034 (Figure 7), where oxidation to the sulfoxide occurred at the thiazin ring 114…”

Microbial growth tests in anti-neoplastic injectable solutions

“…They can monitor the evolution of active substance concentration depending on the formulations, 11 or on microbiological enzymatic degradation. 12 In this last study, an anti-cancer agent (AG2034) was shown to be sensitive to enzymatic degradation. The authors had pointed out that solution sterility increased drugs' stability.…”