Degradation of Candida albicans on TiO2 and Ag-TiO2 thin films prepared by sol–gel and nanosuspensions

Tatlıdil, İlknur; Sökmen, Münevver; Breen, Chris; Clegg, Francis; Buruk, Celal Kurtuluş; Bacaksız, Emin

doi:10.1007/s10971-011-2546-0

Cited by 28 publications

(19 citation statements)

References 21 publications

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“…15 These results suggest that Bi 2 O 3 NPs could be very interesting antifungal agents. Previously, it was reported that zinc, titanium, and silver NPs have very good antifungal activity; [24][25][26] however, it is not possible to establish any quantitative antibiofilm activity comparison, due to the type of published results.…”

Section: Discussionmentioning

confidence: 99%

Bismuth oxide aqueous colloidal nanoparticles inhibit Candida albicans growth and biofilm formation

Hernandez-Delgadillo¹,

Velasco‐Arias²,

Martinez-Sanmiguel³

et al. 2013

IJN

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Multiresistance among microorganisms to common antimicrobials has become one of the most significant concerns in modern medicine. Nanomaterials are a new alternative to successfully treat the multiresistant microorganisms. Nanostructured materials are used in many fields, including biological sciences and medicine. Recently, it was demonstrated that the bactericidal activity of zero-valent bismuth colloidal nanoparticles inhibited the growth of Streptococcus mutans; however the antimycotic potential of bismuth nanostructured derivatives has not yet been studied. The main objective of this investigation was to analyze the fungicidal activity of bismuth oxide nanoparticles against Candida albicans, and their antibiofilm capabilities. Our results showed that aqueous colloidal bismuth oxide nanoparticles displayed antimicrobial activity against C. albicans growth (reducing colony size by 85%) and a complete inhibition of biofilm formation. These results are better than those obtained with chlorhexidine, nystatin, and terbinafine, the most effective oral antiseptic and commercial antifungal agents. In this work, we also compared the antimycotic activities of bulk bismuth oxide and bismuth nitrate, the precursor metallic salt. These results suggest that bismuth oxide colloidal nanoparticles could be a very interesting candidate as a fungicidal agent to be incorporated into an oral antiseptic. Additionally, we determined the minimum inhibitory concentration for the synthesized aqueous colloidal Bi 2 O 3 nanoparticles.

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Section: Discussionmentioning

confidence: 99%

Bismuth oxide aqueous colloidal nanoparticles inhibit Candida albicans growth and biofilm formation

Hernandez-Delgadillo¹,

Velasco‐Arias²,

Martinez-Sanmiguel³

et al. 2013

IJN

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“…TiO 2 film/particles can inactivate C. albicans after 30 to 90 minutes of UV light (315‐400 nm) exposure. Reduction in C. albicans has been shown to be more than 90% . Under UV light irradiation, strong oxidative species including hydroxyl (OH‐), superoxide free radicals (O 2 ‐), or hydrogen peroxide (H 2 O 2 ) are created from photoexcited TiO 2 .…”

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confidence: 99%

Improving Polymethyl Methacrylate Resin Using a Novel Titanium Dioxide Coating

Darwish

Huang

Knoernschild

et al. 2019

Journal of Prosthodontics

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Purpose:The objective of this study was to improve the surface characteristics of poly (methyl methacrylate) (PMMA) by developing a novel, thin film coating process and to characterize the resulting coated surface. Materials and Methods: An atomic layer deposition (ALD) technique was developed to deposit a titanium dioxide (TiO 2 ) nano-thin film on PMMA. The surface wettability for both coated and uncoated PMMA was determined by measuring water contact angle. Wear resistance was assessed using a mechanical tooth-brushing device with a 50 g load for 6000 strokes after 5 months of water storage. A denture cleanser challenge test was performed by using sonication in 3.8% sodium perborate for 1 hour with aged specimens. X-ray photoelectron spectroscopy (XPS) was used before and after the brushing test and challenge test to analyze the PMMA surface chemical composition. The mechanical strength of coated and uncoated PMMA was measured using a three-point bending test. Surface microbial interactions were also evaluated by assessing Candida albicans biofilm attachment. Results: Nano-TiO 2 coating (30 nm thick) was successfully deposited on PMMA at 65°C. After coating, water contact angle decreased from 70°to less than 5°. After brushing test, the coating remained intact. XPS analysis revealed no loss of TiO 2 from coated specimens following brushing and denture cleanser sonication for 1 hour. There was no statistically significant difference in mechanical strength (MPa) (mean ± SD) between PMMA (139.4 ± 11.3) and TiO 2 -PMMA (160.7 ± 37.1) (p = 0.0995). C. albicans attachment decreased by 63% to 77% on the coated PMMA surface. Conclusions: ALD is a promising technique to modify surface properties of PMMA and resulted in a stable adherent thin film. By depositing a TiO 2 coating, PMMA surface properties may lead to significantly reduced microorganism adhesion and easier pathogen removal from PMMA. For patients who wear dentures, reducing the oral microbial biofilm burden using a TiO 2 -coated PMMA surface could positively impact their oral and systemic health.

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“…Nanosized TiO2/TNPs have photocatalytic properties, which are shown to control microbial growth [15,26]. The mechanism of antimicrobial activity is based on the excitation of the electron/efrom the valence band to the conduction band and the generation of the "electron-hole (e -h+)" [27].…”

Section: Discussionmentioning

confidence: 99%

In Vitro Inactivation of Human Coronavirus by Titania Nanoparticle Coatings and UVC Radiation: Throwing Light on SARS-CoV-2

Khaiboullina

Uppal

Dhabarde

et al. 2020

Preprint

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The newly identified pathogenic human coronavirus, SARS-CoV-2, led to an atypical pneumonia-like severe acute respiratory syndrome (SARS) outbreak called coronavirus disease 2019 (COVID-19). Currently, nearly 23 million cases have been confirmed worldwide with the highest COVID-19 cases been confirmed in the United States. As there is no vaccine or any effective interventions, massive efforts to create a potential vaccine to combat COVID-19 is underway. In the meantime, safety precautions and effective disease control strategies appear to be vital for preventing the virus spread in the public places. Due to the longevity of the virus on smooth surfaces, photocatalytic properties of self-disinfecting/cleaning surfaces appear to be a promising tool to help guide disinfection policies to control infectious SAR-CoV-2 spread in high-traffic areas such as hospitals, grocery stores, airports, schools, and stadiums. Here, we explored the photocatalytic properties of nanosized TiO2 (TNPs) as induced by the UV radiation, towards virus deactivation. Our preliminary results using close genetic relative of SAR-CoV-2, HCoV-NL63, showed the virucidal efficacy of photoactive TNPs deposited on glass coverslips, as examined by quantitative RT-PCR and virus culture assays. Efforts to extrapolate the underlying concepts described in this study to SARS-CoV-2 are currently underway.

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Degradation of Candida albicans on TiO2 and Ag-TiO2 thin films prepared by sol–gel and nanosuspensions

Cited by 28 publications

References 21 publications

Bismuth oxide aqueous colloidal nanoparticles inhibit Candida albicans growth and biofilm formation

Bismuth oxide aqueous colloidal nanoparticles inhibit Candida albicans growth and biofilm formation

Improving Polymethyl Methacrylate Resin Using a Novel Titanium Dioxide Coating

In Vitro Inactivation of Human Coronavirus by Titania Nanoparticle Coatings and UVC Radiation: Throwing Light on SARS-CoV-2

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