Microwave strengthened Fenton process oxidation of organophosphorus pesticide wastewater was studied by microwave chemical technology. With the synergistic effect of microwave and Fenton, pesticide wastewater was treated by varying dosage of pH, n[FeSO4•7H2O]/n[H2O2], microwave power and microwave radiation time. Microwave strengthened Fenton process oxidation of organophosphorus pesticide wastewater could achieve good effect and the COD removal rate can be up to 82%.