In the present research, the degradation of tylosin (TYL) by nano Ag/S 2 O 2À 8 process under various reaction conditions was investigated. The experiments were performed in a batch reactor, using nanosilver as a catalyst. Effects of pH, persulfate concentration, temperature, and catalytic nano Ag on the degradation efficiency of TYL by persulfate are examined. For treatment of solutions containing 50 mg/L of TYL, the optimum obtained conditions were: 0.4 g/L of nano Ag, 100 mM of the KPS, initial pH of 6.0, and temperature of 40˚C. The degradation of TYL by nano Ag/S 2 O 2À 8 oxidation process has been found to follow the pseudo-first-order kinetic model. Finally rate equation for TYL degradation using Langmuir-Hinshelwood kinetic model is: r ¼ 9630:5 exp À 32:552 RT C 0:9925