Degradation of fluoroquinolone antibiotics during ionizing radiation treatment and assessment of antibacterial activity, toxicity and biodegradability of the products

Tegze, Anna; Sági, Gyuri; Kovács, Krisztina; Homlok, Renáta; Tóth, Tünde; Mohácsi-Farkas, Csilla; Wojnárovits, László; Takács, Erzsébet

doi:10.1016/j.radphyschem.2018.02.015

Cited by 54 publications

(18 citation statements)

References 32 publications

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“…In the present study, the initial concentration of GAT (500 μg L À1 ) did not show adverse effects to V. fischeri, probably due to the short contact time employed in the assay. This result was also observed by De Oliveira et al (2017) and Tegze et al (2018) in their studies with 15 and 30 min of exposure, respectively.…”

Section: Acute Toxicity Assayssupporting

confidence: 79%

Evaluation of residual antimicrobial activity and acute toxicity during the degradation of gatifloxacin by ozonation

Caianelo

Rodrigues-Silva

Maniero

et al. 2021

Water Science and Technology

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The concerns regarding the occurrence of pharmaceuticals in wastewater treatment plants have been increased in the last decades. Gatifloxacin (GAT), the fourth generation of fluoroquinolones, has been widely used to treat both Gram-positive and Gram-negative bacteria and has a limited metabolization. The present study aimed to evaluate the ozonation as a technique to degrade GAT. A UHPLC-MS/MS method was used to quantify the residual of GAT and to assess its degradation products. The removal efficiency was higher at alkaline condition (pH = 10), reaching up to 99% of GAT after 4 min. It was also observed that the first ozone attack on the GAT molecule was through the carboxylic group. In contrast, at acid conditions (pH = 3), the ozone attack was first to the piperazinyl ring. The antimicrobial activity was evaluated using Escherichia coli and Bacillus subtilis as test organisms, and it was observed that the residual activity reduced most at the alkaline conditions. In contrast, the best condition to remove the residual toxicity evaluated for the marine bacteria V. fischeri was the acidic one. Due to this, the ozonation seemed to be an exciting process to remove GAT at aqueous media.

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Section: Acute Toxicity Assayssupporting

confidence: 79%

Evaluation of residual antimicrobial activity and acute toxicity during the degradation of gatifloxacin by ozonation

Caianelo

Rodrigues-Silva

Maniero

et al. 2021

Water Science and Technology

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“…The biodegradability was characterized by the ratio between Biochemical Oxygen Demand at 5 days (BOD 5 ) and COD 52 . This ratio must be greater than 0.4 to consider that the solution is easily biodegradable 53 .…”

Section: Biodegradability Assays and Study Of Feasibility Of The Coupmentioning

confidence: 99%

Treatment of statins drug (pravastatin and rosuvastatin) in water by electro-Fenton process: Kinetics of degradation/mineralization and optimization of experimental conditions for a biological post-treatment

Beqqal¹,

Yahya²,

Miloud³

et al. 2019

Mediterr.J.Chem.,

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The treatment of pravastatin and rosuvastatin contaminated water as much as toxic and persistent organic pollutant was carried out by Electro-Fenton method EF. Several experiments were conducted in a cell compartment equipped with a platinum anode and a carbon felt cathode. The effects of several parameters such as the applied current and the catalyst Fe 2+ concentration have been studied. Mineralization aqueous solutions of pravastatin followed by the chemical oxygen demand COD gave a higher degree of reduction of more than 90% for 6 hours of treatment at a current of 100 mA and Fe 2+ concentration of 0.2 mM. The study of the degradation kinetics was followed during electrolysis by HPLC giving a pseudo first order reaction using a current of 100 mA and Fe 2+ concentration of 0.1mM. A number of intermediate products for pravastatin and rosuvastatin have been identified using HPLC and liquid chromatography-mass spectrometry analyses. Biodegradability of the pretreated solutions of two statins by EF was evaluated in order to decide the optimal moment to introduce the biological process. It was given by the ratio BOD 5 /COD which increases from 0 initially to 1.3 after 2 hours for pravastatin and from 0 initially to 1.5 after 3 hours for rosuvastatin as the COD decreases. It implies that EF tends to enhance the biodegradability and could be used as a pre-treatment step for biological treatment.

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“…This technology is based on the action of oxidative molecules produced during water radiolysis and chemical degradation. Some examples in this regard include studies on diclofenac (Homlok et al, 2011;Yu et al, 2013;Tominaga et al, 2018) fluoroquinolone antibiotics (Tegze et al, 2018); sulfonamide antibiotics (Sági et al, 2018) and chloramphenicol (Csay et al, 2012);paracetamol (Szabo et al, 2012) degradation and detoxification, as well as fluoxetine in municipal sewage (Silva et al, 2016), among others. However, most studies are carried out with pure substances, not mixtures.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, advanced treatment-processing studies considering pharmaceutical mixtures are scarce in the literature, indicating a knowledge gap in this regard. Previous studies demonstrated that relatively low doses were enough to reduce toxicity and other paramethers in different effluents (Silva et al, 2016;Tegze et al, 2018;Tominaga et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Electron beam irradiation of pharmaceuticals aiming at toxicity reduction: a binary mixture of fluoxetine and propranolol

Boiani¹,

Silva

Garcia

et al. 2024

Ecotoxicol. Environ. Contam.

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Significant evidence is available in the literature justifying the search for treatment technologies or process combinations to improve the decomposition of dozens of pharmaceuticals in wastewater. Conventional processing techniques are insufficient in removal of the pharmaceuticals, for having resistant waste and low biodegradability. Electron beam irradiation (EBI) may play an important role in this context, and relatively low doses have been reported for such purposes. The objective of this study was to apply the process of irradiation with electron beam in order to reduce the toxic effects of fluoxetine, propranolol, and a binary mixture of these pharmaceuticals in aqueous solution. Ecotoxicological tests conducted in two model organisms, Daphnia similis microcrustacean, and Vibrio fischeri bacterium. It was observed that D. similis was more sensitive to the pharmaceuticals and binary mixture, when compared to V. fischeri. When EBI was applied, all doses showed significant reduction of toxicity for D. similis, and the opposite for V. fischeri, when only 5.0 kGy showed a significant reduced of toxicity for the pharmaceuticals and binary mixture. 5.0 kGy was the best removal efficiency for toxicity, approximately 80% for D. similis and 20% for V. fischeri.

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Degradation of fluoroquinolone antibiotics during ionizing radiation treatment and assessment of antibacterial activity, toxicity and biodegradability of the products

Cited by 54 publications

References 32 publications

Evaluation of residual antimicrobial activity and acute toxicity during the degradation of gatifloxacin by ozonation

Evaluation of residual antimicrobial activity and acute toxicity during the degradation of gatifloxacin by ozonation

Treatment of statins drug (pravastatin and rosuvastatin) in water by electro-Fenton process: Kinetics of degradation/mineralization and optimization of experimental conditions for a biological post-treatment

Electron beam irradiation of pharmaceuticals aiming at toxicity reduction: a binary mixture of fluoxetine and propranolol

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