1983
DOI: 10.1016/s0006-291x(83)80263-0
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Degradation of neurotensin by rabbit brain endo-oligopeptidase A and endo-oligopeptidase B (proline-endopeptidase)

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Cited by 60 publications
(17 citation statements)
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“…174,175 While DISC1 has no known role in the activity of platelet-activating factor acetylhydrolase, EOPA activity is inhibited by DISC1 overexpression, 173 thus implicating DISC1 in the regulation of NDEL1 oligopeptidase activity, and hence in neuropeptide metabolism.…”
Section: Lis1 Ndel1 Nde1 and Disc1mentioning
confidence: 99%
“…174,175 While DISC1 has no known role in the activity of platelet-activating factor acetylhydrolase, EOPA activity is inhibited by DISC1 overexpression, 173 thus implicating DISC1 in the regulation of NDEL1 oligopeptidase activity, and hence in neuropeptide metabolism.…”
Section: Lis1 Ndel1 Nde1 and Disc1mentioning
confidence: 99%
“…Ndel1, also known as endo-oligopeptidase A (EOPA), is a cysteine protease and has oligopeptidase activity, which is inhibited by DISC1 in in vitro assays [72]. Ndel1/EOPA inactivates bioactive peptides such as bradykinin and neurotensin, and converts opioid oligopeptides into enkephalins [7375]. A recent study has shown that the endo-oligopeptidase activity of Ndel1 plays a crucial role in the differentiation process of PC12 cells to neurons [76].…”
Section: Structure and Function Of Disc1 And Its Key Interactorsmentioning
confidence: 99%
“…Ndel1/EOPA, is a thiol-sensitive enzyme inactivates physiologically important peptides such as bradykinin and neurotensin, and also converts opioid oligopeptides into enkephalins (Camargo et al, 1973(Camargo et al, , 1983(Camargo et al, , 1987Gomes et al, 1993;Hayashi et al, 2000. The contribution of bradykinin and neurotensin neuropeptides in neurite outgrowth was also previously described (Zhao et al, 2003;Tischler et al, 1991;Robson and Burgoyne, 1989;Tischler et al, 1984).…”
Section: Lis1 and Ndel1: Microtubule Associated Proteins Involved In mentioning
confidence: 85%