Degradation of nucleic acid in aqueous solution by ionizing radiation

Interaction between DNA and aminothiol radioprotectors has been proved to be purely peripheral, i.e., it does not affect the bases but solely the sugar-phosphate backbone. (This interaction is essentially electrostatic, between the phosphate sites and the radioprotector cationic groups.)In order to progress in the understanding of the conformational aspects of this interaction, we have carried out a quantum mechanical simulation of the approach by a cysteamine molecule of the DNA backbone.Major conclusions drawn from this study are: ( I ) The ab-inirio calculation of the charge distribution on the cysteamine radioprotector cation shows that this molecule possesses a positive NH3 head and SH tail. (2) The XILO energy variations of the supermolecule (dideoxyrihe-triphosphate + cysteamine) show minimal zones which enable us to specify the positions and the distortion of the cysteamine radioprotector in interaction with the DNA backbone.

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Quantum Mechanical Simulation of the Interaction Between the Radioprotector cysteamine and DNA

Broch

Cabrol

Vasilescu

2009

Int. J. Quantum Chem.

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Low doses of α- and γ-radiation enhance DNA thermal stability

Georgakilas

Sideris

Sakelliou

et al. 1999

Biophysical Chemistry

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Degradation of nucleic acid in aqueous solution by ionizing radiation

Cited by 2 publications

References 11 publications

Quantum Mechanical Simulation of the Interaction Between the Radioprotector cysteamine and DNA

Quantum Mechanical Simulation of the Interaction Between the Radioprotector cysteamine and DNA

Low doses of α- and γ-radiation enhance DNA thermal stability

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