Nowadays, dyes are usually chemically stable, can not be degraded naturally within a short time, and easy to migrate along with water, which is the main source to influence the health of human beings and to destroy the ecosystem. Based on that, in this work a high-performance photocatalyst was prepared successfully by an organic synthesis method. The obtained photocatalyst contained numerous nanoscale heterojunctions, which consisted of CdSe nanoparticles scattered on the partially reduced graphene oxide (named as CdSe / RGO-GO). The samples were characterized by photoluminescence spectra (PL), transmission electron microscopy (TEM), and ultraviolet and visible spectrophotometry (UV-vis). The photocatalytic activity was evaluated by the degradation of organic dyes Rhodamine B (RhB) aqueous solution under irradiation of visible light and no light. Results show that the degradation efficiency of nanocomposites was 84.4 % in the first 10 minutes under darkness. After 50 minutes of visible light irradiation, the degradation efficiency was 94 %. The high degradation efficiency of photocatalysts attributes to the synergistic effect of graphene oxide adsorption and heterojunctions catalysis. CdSe / RGO-GO photocatalyst reported in this paper has a series of advantages, such as pollutionfree, recyclability, stability, and insolubility in water. The preparation of CdSe / RGO-GO composites has potential applications in curbing pollution.