Degradation of organophosphate esters in sewage sludge: Effects of aerobic/anaerobic treatments and bacterial community compositions

Pang, Long; Ge, Liming; Peng, Yang; He, Han; Zhang, Hongzhong

doi:10.1016/j.dib.2018.02.039

Cited by 7 publications

(5 citation statements)

References 7 publications

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“…This protein has previously been implicated in diabetes incidence and the control of food intake 25 , 26 , acting via receptors in the hind brain 10 . GDF-15 has also been reported to serve as a useful biomarker for impaired fasting glucose 27 and diabetic kidney disease 28 as well as a number of conditions including cardiovascular disease 29 , 30 GDF15 is strongly elevated following metformin exposure, due to release from the gut 31 . Of note, we did not show any attenuation of the GDF15 signal with progression when adjusting for whether the patients were treated with metformin at the time of blood sampling.…”

Section: Discussionmentioning

confidence: 99%

Identification of biomarkers for glycaemic deterioration in type 2 diabetes

et al. 2023

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We identify biomarkers for disease progression in three type 2 diabetes cohorts encompassing 2,973 individuals across three molecular classes, metabolites, lipids and proteins. Homocitrulline, isoleucine and 2-aminoadipic acid, eight triacylglycerol species, and lowered sphingomyelin 42:2;2 levels are predictive of faster progression towards insulin requirement. Of ~1,300 proteins examined in two cohorts, levels of GDF15/MIC-1, IL-18Ra, CRELD1, NogoR, FAS, and ENPP7 are associated with faster progression, whilst SMAC/DIABLO, SPOCK1 and HEMK2 predict lower progression rates. In an external replication, proteins and lipids are associated with diabetes incidence and prevalence. NogoR/RTN4R injection improved glucose tolerance in high fat-fed male mice but impaired it in male db/db mice. High NogoR levels led to islet cell apoptosis, and IL-18R antagonised inflammatory IL-18 signalling towards nuclear factor kappa-B in vitro. This comprehensive, multi-disciplinary approach thus identifies biomarkers with potential prognostic utility, provides evidence for possible disease mechanisms, and identifies potential therapeutic avenues to slow diabetes progression.

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Section: Discussionmentioning

confidence: 99%

Identification of biomarkers for glycaemic deterioration in type 2 diabetes

et al. 2023

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“…Male subjects were more abundant in the cohorts (>55%), and the average age ranged from 61-67 years with a BMI of 30-32 kg/m 2 . Glycated haemoglobin (HbA1c) levels were on average lowest in DCS (median[Q25-Q75]: 47.08 [42][43][44][45][46][47][48][49][50] mmol/mol), followed by GoDARTS (55.54 [46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61] mmol/mol) and ANDIS (60.06[46.0-68.0]). The time from diagnosis to sampling time ranged from 0 to 2.63 years.…”

Section: Cohort Characteristics and Modelling Of Glycaemic Deteriorationmentioning

confidence: 99%

“…This protein has previously been implicated in diabetes incidence and the control of food intake 43,44 , acting via receptors in the hind brain. 28 GDF-15 has also been reported to serve as a useful biomarker for impaired fasting glucose 45 and diabetic kidney disease 46 as well as a number of conditions including cardiovascular disease 47,48 GDF15 is strongly elevated following metformin exposure, due to release from the gut. 49 Of note, we did not show any attenuation of the GDF15 signal with progression when adjusting for whether the patients were treated with metformin at the time of blood sampling.…”

Section: Proteins and Glycaemic Deteriorationmentioning

confidence: 99%

Novel biomarkers for glycaemic deterioration in type 2 diabetes: an IMI RHAPSODY study

López-Noriega

et al. 2021

Preprint

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We have deployed a multi-omics approach in large cohorts of patients with existing type 2 diabetes to identify biomarkers for disease progression across three molecular classes, metabolites, lipids and proteins. A Cox regression analysis for association with time to insulin requirement in 2,973 patients in the DCS, ANDIS and GoDARTS cohorts identified homocitrulline, isoleucine and 2-aminoadipic acid, as well as the bile acids glycocholic and taurocholic acids, as predictive of more rapid deterioration. Increased levels of eight triacylglycerol species, and lowered levels of the sphingomyelin SM 42:2;2 were also predictive of disease progression. Of ∼1,300 proteins examined in two cohorts, levels of GDF-15/MIC1, IL-18RA, CRELD1, NogoR, FAS, and ENPP7 were associated with faster progression, whilst SMAC/DIABLO, COTL1, SPOCK1 and HEMK2 predicted lower progression rates. Strikingly, identified proteins and lipids were also associated with diabetes incidence and prevalence in external replication cohorts. Implicating roles in disease compensation, NogoR/RTN4R improved glucose tolerance in high fat-fed mice and tended to improved insulin signalling in liver cells whilst IL-18R antagonised inflammatory IL-18 signalling towards nuclear factor kappa-B in vitro. Conversely, high NogoR levels led to islet cell apoptosis. This comprehensive, multi-disciplinary approach thus identifies novel biomarkers with potential prognostic utility, provides evidence for new disease mechanisms, and identifies potential therapeutic avenues to slow diabetes progression.

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“…OP triesters were not completely removed in WWTPs following advanced oxidation processes (Cristale et al, 2016;Liang et al, 2016). Low removal rates of OP triesters also were reported following aerobic composting of sewage sludge (Pang et al, 2018). Thus far, only a few studies have reported on the occurrence of OP triesters and diesters in sewage sludge from the US (Kim et al, 2017), European countries (Celano et al, 2014;Marklund et al, 2005), and China (Fu et al, 2017;Gao et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

A nationwide survey of 31 organophosphate esters in sewage sludge from the United States

Kannan

Halden

et al. 2019

Science of The Total Environment

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Organophosphate esters (OPEs) are used as flame retardants and plasticizers in a wide range of consumer products. Nevertheless, studies on the occurrence and inventory of OPEs in sewage sludge are limited. In this study, 20 OP triesters and 11 diesters were measured in 75 archived sewage sludge samples collected from 67 wastewater treatment plants (WWTPs) across the United States (US). The median concentrations of ∑ 20 OP-triesters and ∑ 11 OP-diesters in sludge were 1,290 and 78.4 ng/g dry weight (dw), respectively. Sludge samples originating from the Western and Northeastern US contained higher concentrations of OP triesters than did those from the Midwestern and Southern US. Sludge samples from WWTPs with larger treatment capacity (>38 million liters per day) contained higher concentrations of OP diesters (p <0.05). OP diesters in sludge originated from two sources, triester degradation and direct inputs. Land application of sludge to US soils was estimated to result in annual mass inputs of 12,400-14,900 kg/year of OP triesters and 663-796 kg/year of OP diesters. A hazard assessment was performed for 14 OPEs found in sludge, which suggested a low level of risk from OPs at the current land application practices of sludge.

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Degradation of organophosphate esters in sewage sludge: Effects of aerobic/anaerobic treatments and bacterial community compositions

Cited by 7 publications

References 7 publications

Identification of biomarkers for glycaemic deterioration in type 2 diabetes

Identification of biomarkers for glycaemic deterioration in type 2 diabetes

Novel biomarkers for glycaemic deterioration in type 2 diabetes: an IMI RHAPSODY study

A nationwide survey of 31 organophosphate esters in sewage sludge from the United States

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