1984
DOI: 10.1016/0142-9612(84)90002-4
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Degradation of poly (isobutyl cyanoacrylate) nanoparticles

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Cited by 257 publications
(85 citation statements)
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“…It is now well established that cyanoacrylate nanoparticles are biodegradable. Their degradation mechanism involves an enzymatic degradation with hydrolysis of the ester function, leading to the formation of the soluble cyanoacrylic acid and the corresponding alcohols (i.e., hexadecanol for PHDCA and PEG-PHDCA, as well as polyethylene glycol for PEG-PHDCA) (Lenaerts et al, 1984). In addition, the biodegradation rate of poly(cyanoacrylate) depends on the length of the alkyl chain (Couvreur et al, 1979), with hexadecyl being more slowly degraded compared with isohexyl and isobutyl.…”
Section: Resultsmentioning
confidence: 99%
“…It is now well established that cyanoacrylate nanoparticles are biodegradable. Their degradation mechanism involves an enzymatic degradation with hydrolysis of the ester function, leading to the formation of the soluble cyanoacrylic acid and the corresponding alcohols (i.e., hexadecanol for PHDCA and PEG-PHDCA, as well as polyethylene glycol for PEG-PHDCA) (Lenaerts et al, 1984). In addition, the biodegradation rate of poly(cyanoacrylate) depends on the length of the alkyl chain (Couvreur et al, 1979), with hexadecyl being more slowly degraded compared with isohexyl and isobutyl.…”
Section: Resultsmentioning
confidence: 99%
“…27 Lenaerts et al have shown that this route of degradation played a marginal role when compared with the enzymatic route of degradation. 28 The influence of pH on degradation of poly(alkylcyanoacrylates) has also been studied in detail, eg, in the work of Scherer et al 25 The degradation rate increased with increasing pH; however, after uptake in cells via the endocytotic pathway, the pH will decrease from early endosomes to lysosomes, making this route of degradation less likely.…”
mentioning
confidence: 99%
“…If degradation happens in the presence of esterase, it was shown that the degradation of the polymer in esterase-free medium is low, therefore, the drug release rate is low accordingly. The drug release was increased when the medium contained carboxyesterase (72).…”
Section: Antibiotic Loaded Cyanoacrylate Nanoparticlesmentioning
confidence: 93%