Degradation of polydispersed poly(l-lactic acid) to modulate lactic acid release

Recum, Horst A. von; Cleek, Robert L.; Eskin, Suzanne G.; Mikos, Antonios G.

doi:10.1016/0142-9612(95)98816-w

Cited by 106 publications

(54 citation statements)

References 15 publications

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“…The scission of ester groups due to hydrolytic degradation produces low molecular Similar results have been observed in other studies on the degradation of PLLA membranes [15,28]. The increased crystallinity can be attributed to the fact that degradation mainly affects the amorphous phase, producing the reorganization of the low molecular-weight chains into new crystallites.…”

Section: Discussionsupporting

confidence: 73%

Study of the degradation of a new PLA braided biomaterial in buffer phosphate saline, basic and acid media, intended for the regeneration of tendons and ligaments

Araque-Monrós

Vidaurre

Gil-Santos

et al. 2013

Polymer Degradation and Stability

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The purpose of this study was to evaluate the effects of hydrolytic degradation on the properties of a PLA hollow braid designed as a new concept of biodegradable prosthesis for the regeneration of tendons and ligaments. The main function of the braided material is to bear mechanical loads while it is being replaced by the newly-generated tissue. The kinetics of braided material degradation is thus an important factor in determining the success of the product. In order to study this mechanism, PLA braid was subjected to a 12-month degradation process at 37ºC in PBS at pH 7.4 (to simulate the human physiological medium) and to accelerated degradation for one month in pH 12 and pH 3solutions. Degradation of the braid subjected to hydrolysis was evaluated by weight loss, molecular weight distribution, mechanical properties, and calorimetric and morphologic analyses. The weight loss in a basic medium reached 21%, versus no significant change in the other media. Average molecular weight was reduced by approximately 50% in the three media, with loss of mechanical properties in all cases.The morphological changes were more evident in the PLA degraded in the basic medium. The crystallinity of the material increased on first stages of degradation, regardless of the medium used.

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Section: Discussionsupporting

confidence: 73%

Study of the degradation of a new PLA braided biomaterial in buffer phosphate saline, basic and acid media, intended for the regeneration of tendons and ligaments

Araque-Monrós

Vidaurre

Gil-Santos

et al. 2013

Polymer Degradation and Stability

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“…It has been reported that polymer scaffolds such as PLA may induce an inflammatory reaction, as this polymer releases lactic acid during its degradation [21]. It is the accumulation of this acid which becomes toxic [22]. The initial fibrous tissue formation observed in this study has been previously reported with PLA implants inserted into rabbits [20].…”

Section: Discussionsupporting

confidence: 66%

Augmentation of bone defect healing using a new biocomposite scaffold: An in vivo study in sheep

et al. 2010

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a b s t r a c tPrevious studies support resorbable biocomposites made of poly(L-lactic acid) (PLA) and b-tricalcium phosphate (TCP) produced by supercritical gas foaming as a suitable scaffold for tissue engineering. The present study was undertaken to demonstrate the biocompatibility and osteoconductive properties of such a scaffold in a large animal cancellous bone model. The biocomposite (PLA/TCP) was compared with a currently used b-TCP bone substitute (ChronOS™, Dr. Robert Mathys Foundation), representing a positive control, and empty defects, representing a negative control. Ten defects were created in sheep cancellous bone, three in the distal femur and two in the proximal tibia of each hind limb, with diameters of 5 mm and depths of 15 mm. New bone in-growth (osteoconductivity) and biocompatibility were evaluated using microcomputed tomography and histology at 2, 4 and 12 months after surgery. The in vivo study was validated by the positive control (good bone formation with ChronOS™) and the negative control (no healing with the empty defect). A major finding of this study was incorporation of the biocomposite in bone after 12 months. Bone in-growth was observed in the biocomposite scaffold, including its central part. Despite initial fibrous tissue formation observed at 2 and 4 months, but not at 12 months, this initial fibrous tissue does not preclude long-term application of the biocomposite, as demonstrated by its osteointegration after 12 months, as well as the absence of chronic or long-term inflammation at this time point.

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“…This can suggest the formation of a conglomerate of chains spanning a wide range of molecular weights indicating chain scission [29]. For the 0.5 MeV and 1.5 MeV (150 kGy/500 kGy) samples, PI values show a depth dependent variation similar to that observed for the Mn results with increased PI values obtained for the surface layers which then decrease with depth thereafter.…”

Section: Discussionsupporting

confidence: 51%

Electron-beam treatment of poly(lactic acid) to control degradation profiles

Cairns

Dickson

Orr

et al. 2011

Polymer Degradation and Stability

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Degradation of polydispersed poly(l-lactic acid) to modulate lactic acid release

Cited by 106 publications

References 15 publications

Study of the degradation of a new PLA braided biomaterial in buffer phosphate saline, basic and acid media, intended for the regeneration of tendons and ligaments

Study of the degradation of a new PLA braided biomaterial in buffer phosphate saline, basic and acid media, intended for the regeneration of tendons and ligaments

Augmentation of bone defect healing using a new biocomposite scaffold: An in vivo study in sheep

Electron-beam treatment of poly(lactic acid) to control degradation profiles

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