Degradation of polymeric systems aimed at temporary therapeutic applications: Structure-related complications

Vert, Michel

doi:10.1515/epoly.2005.5.1.70

Cited by 13 publications

(18 citation statements)

References 8 publications

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“…Hydrolytic degradation is of crucial importance [7,8] for its successful implementation in applications such as surgical sutures, drug delivery systems, and tissue engineering scaffolds. The rate of degradation has been attributed to a number of polymer characteristics.…”

Section: Introductionmentioning

confidence: 99%

A comparative study on Poly(ε-caprolactone) film degradation at extreme pH values

Sailema-Palate

Vidaurre

Campillo-Fernández

et al. 2016

Polymer Degradation and Stability

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a b s t r a c tThe present paper studies the effect of pH on hydrolytic degradation of Poly(ε-caprolactone) (PCL) Degradation of the films was performed at 37 C in 2.5 M NaOH solution (pH 13) and 2.5 M HCl solution (pH 1). Weight loss, degree of swelling, molecular weight, and calorimetric and mechanical properties were obtained as a function of degradation time. Morphological changes in the samples were carefully studied through electron microscopy. At the start of the process the degradation rate of PCL films at pH 13 was faster than at pH 1. In the latter case, there was an induction period of around 300 h with no changes in weight loss or swelling rate, but there were drastic changes in molecular weight and crystallinity. The changes in some properties throughout the degradation period, such as crystallinity, molecular weight and Young's modulus were lower in degradations at higher pH, highlighting differences in the degradation mechanism of alkaline and acid hydrolysis. Along with visual inspection of the degraded samples, this suggests a surface degradation at pH 13, whereas bulk degradation may occur at pH 1.

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Section: Introductionmentioning

confidence: 99%

A comparative study on Poly(ε-caprolactone) film degradation at extreme pH values

Sailema-Palate

Vidaurre

Campillo-Fernández

et al. 2016

Polymer Degradation and Stability

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“…The most important role of the use of scaffold in vivo is that it persists in a robust state for sufficient time to allow the formation of new tissue, but also ultimately degrading and becoming replaced by this tissue. For its successful implementation in applications such as surgical sutures, drug delivery systems, and tissue engineering scaffolds, hydrolytic degradation is of crucial importance [1,2].…”

Section: Introductionmentioning

confidence: 99%

Hydrolytic and enzymatic degradation of a poly(ε-caprolactone) network

Castilla-Cortázar¹,

Más-Estellés²,

Dueñas³

et al. 2012

Polymer Degradation and Stability

149

116

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Long-term hydrolytic and enzymatic degradation profiles of poly(ε-caprolactone) (PCL) networks were obtained. The hydrolytic degradation studies were performed in water and phosphate buffer solution (PBS) for 65 weeks. In this case, the degradation rate of PCL networks was faster than previous results in the literature on linear PCL, reaching a weight loss of around 20% in 60 weeks after immersing the samples either in water or PBS conditions. The enzymatic degradation rate in Pseudomonas Lipase for 14 weeks was also studied, with the conclusion being that the degradation profile of PCL networks is lower than for linear PCL, also reaching a 20% weight loss. The weight lost, degree of swelling, and calorimetric and mechanical properties as a function of degradation time were obtained. Furthermore, the morphological changes in the samples were studied carefully through electron microscopy and crystal size through X-ray diffraction. The changes in some properties over the degradation period such as crystallinity, crystal size and Young's modulus were smaller in the case of enzymatic studies, highlighting differences in the degradation mechanism in the two studies, hydrolytic and enzymatic.

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“…Indeed, it has been shown that after balloon angioplasty, restenosis is mainly because of constrictive remodeling. [16][17][18][19] Our goal was to prevent this process by scaffolding the arterial wall during a limited time (ie, 3 months) and then to unjail the artery to allow positive remodeling occurring in response to increased flow. Neointimal formation resulted in rapid BRS coverage and was associated with positive remodeling, as shown earlier.…”

Section: Discussionmentioning

confidence: 99%

“…Neointimal formation resulted in rapid BRS coverage and was associated with positive remodeling, as shown earlier. [16][17][18][19] Eventually, the scaffold resorption was designed to occur between 18 and 24 months. The ability of lactic acid-based polymers to degrade has been known for more than 40 years and is well documented in literature.…”

Section: Discussionmentioning

confidence: 99%

“…The degradation of macromolecules was well advanced at 3 months with degradation slowing down thereafter because of enrichment in hydrolysis-resistant crystalline residues. 18 The content in crystalline domains of partially degraded lactic acid stereocopolymers is always much lower than in the case of the PLLA homopolymer, the length of the stereoregular segments being dramatically decreased even by 1 or 2% D-units only. 19 Table 4 shows that for BRS the content in water was undetectable before implantation, but it increased rapidly soon after from 0 to 1%, 3.5%, and 6.9% at 1, 3, and 6 months, respectively.…”

Section: Polymer Degradationmentioning

confidence: 95%

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Head-to-Head Comparison of a Drug-Free Early Programmed Dismantling Polylactic Acid Bioresorbable Scaffold and a Metallic Stent in the Porcine Coronary Artery

Durand

Sharkawi

Lochard

et al. 2014

Circ: Cardiovascular Interventions

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Background-We aimed to evaluate a new drug-free fully bioresorbable lactic acid-based scaffold designed to allow early dismantling synchronized with artery wall healing in comparison with a bare metal stent (BMS). Methods and Results-Twenty-three BMS (3.0×12 mm) and 36 lactic acid-based bioresorbable scaffolds (BRS, 3.0×11 mm) were implanted in porcine coronary arteries. QCA and optical coherence tomographic analyses were performed immediately after implantation and repeated after 1, 3, and 6 months. Microcomputed tomography was used to detect scaffold dismantling. Polymer degradation was evaluated throughout the study. The primary end-point was late lumen loss, and the secondary end-points were scaffold/stent diameter and acute recoil. Acute recoil was low and comparable between the BRS and the BMS groups (4.6±6.7 versus 4.6±5.1%; P=0.98). BRS outer diameter increased significantly from 1 to 6 months indicating late positive scaffold remodeling (P<0.0001), whereas BMS diameter remained constant (P=0.159). Late lumen loss decreased significantly from 1 to 6 months in the BRS group (P=0.003) without significant difference between BRS and BMS groups at 6 months (P=0.68). Microcomputed tomography identified BRS dismantling starting at 3 months, and weight-average molar masses of scaffold parts were 20% and 14% of their initial values at 3 and 6 months. Conclusions-BRS and BMS have similar 6-month outcomes in porcine coronary arteries. Interestingly, BRS dismantling was detected from 3 months and resulted in late lumen enlargement by increased scaffold diameter at 6 months. (Circ Cardiovasc Interv. 2014;7:70-79.)

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Degradation of polymeric systems aimed at temporary therapeutic applications: Structure-related complications

Cited by 13 publications

References 8 publications

A comparative study on Poly(ε-caprolactone) film degradation at extreme pH values

A comparative study on Poly(ε-caprolactone) film degradation at extreme pH values

Hydrolytic and enzymatic degradation of a poly(ε-caprolactone) network

Head-to-Head Comparison of a Drug-Free Early Programmed Dismantling Polylactic Acid Bioresorbable Scaffold and a Metallic Stent in the Porcine Coronary Artery

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