Degradation of soluble VEGF receptor-1 by MMP-7 allows VEGF access to endothelial cells

Interleukin-10 overexpression improves the function of endothelial progenitor cells stimulated with TNF-α through the activation of the STAT3 signaling pathway

“…Active MMPs degrade vascular basement membrane and other extracellular matrix (ECM) proteins leading to detaching of ECs, which is necessary for proliferation (28), migration (29) and even apoptosis of ECs (30) and is an initial step of angiogenesis or vascular formation. In addition, MMPs can modify non-ECM molecules, such as VEGFR, to affect EC vitality and behavior (31). In addition, deficiency of MMP-9 attenuates ischemia-induced neovascularization through an impairment of bone marrow-derived EPC adhesion, migration and proangiogenic functions (32).…”

Functional single nucleotide polymorphisms of matrix metalloproteinase 7 and 12 genes in idiopathic recurrent spontaneous abortion

“…Consequently, it has been suggested that MMP7 is important in the implantation process [40,41]. Furthermore, MMP7 degrades soluble vascular endothelial growth factor receptor 1 (sVEGFR1) and increases the bioavailability of VEGF 165 , which promotes angiogenesis [42]. The G allele of the MMP7 -181 A/G SNP creates a putative binding site for a heat shock transcription factor, thereby increasing MMP7 gene promoter activity and transcription compared to the -181 A allele [34].…”

Advancing Biomarker Science in the 21st Century

“…Last, soluble receptors can be expressed from alternately spliced mRNAs, exerting an effect in the absence a ligand-induced regulatory mechanism. 7,8 …”

“…6,7,8 Transmembrane receptors are ubiquitous in biological systems and transmit information from the outside to the inside of the cell. A traditional view of transmembrane protein and glycoprotein receptors questions their functional role in the soluble state; however, a contemporary perspective suggests otherwise.…”