Degradation of the antiviral drug oseltamivir carboxylate in surface water samples

Accinelli, Cesare; Caracciolo, Anna Barra; Grenni, Paola

doi:10.1080/03067310601151894

Cited by 44 publications

(21 citation statements)

References 26 publications

(33 reference statements)

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“…Previous investigations indicate that a considerable amount of OC is not broken down during water treatment processes and is broken down slowly during natural processes, which can lead to the accumulation of OC in the environment (21)(22)(23)(24)(25)(26)(27)(28). Therefore, the demonstrated ability of OC in drinking water to select OCresistant influenza H5N2 virus variants is of concern considering that OC-resistant viruses are already increasing in frequency in human populations (7,(10)(11)(12), even in areas of low oseltamivir drug use (8).…”

Section: Discussionmentioning

confidence: 99%

“…Importantly, OC is poorly removed or degraded by natural environmental conditions or sewage treatment (21)(22)(23)(24)(25)(26)(27)(28), resulting in significant retention in waterways. These same waterways often support large numbers of waterfowl, the primary reservoir of avian influenza A viruses (AIVs), and waterfowl in several parts of the world are likely exposed over lengthy periods to at least low doses of OC in their drinking water.…”

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confidence: 99%

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Effect of Oseltamivir Carboxylate Consumption on Emergence of Drug-Resistant H5N2 Avian Influenza Virus in Mallard Ducks

Achenbach

Bowen

2013

Antimicrob Agents Chemother

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Oseltamivir carboxylate (OC) has been detected in environmental waters at various levels during recent influenza seasons in humans, reflecting levels of usage and stability of this drug. In consideration of the role of waterfowl as hosts for influenza viruses that may contribute to human infections, we evaluated the effect of consumption of low doses of OC on development of oseltamivir-resistant influenza virus mutants in mallard ducks (Anas platyrhynchos) infected with two different low-pathogenic (LP) H5N2 avian influenza viruses (AIV). We detected development of virus variants carrying a known molecular marker of oseltamivir resistance (neuraminidase E119V) in 4 out of 6 mallards infected with A/Mallard/Minnesota/182742/1998 (H5N2) and exposed to 1,000 ng/liter OC. The mutation first appeared as a minor population on days 5 to 6 and was the dominant genotype on days 6 to 8. Oseltamivir-resistant mutations were not detected in virus from ducks not exposed to the drug or in ducks infected with a second strain of virus and similarly exposed to OC. Virus isolates carrying the E119V mutation displayed in vitro replication kinetics similar to those of the wild-type virus, but in vivo, the E119V virus rapidly reverted back to wild type in the absence of OC, and only the wild-type parental strain was transmitted to contact ducks. These results indicate that consumption by wild waterfowl of OC in drinking water may promote selection of the E119V resistance mutation in some strains of H5N2 AIV that could contribute to viruses infecting human populations.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Effect of Oseltamivir Carboxylate Consumption on Emergence of Drug-Resistant H5N2 Avian Influenza Virus in Mallard Ducks

Achenbach

Bowen

2013

Antimicrob Agents Chemother

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“…Zidovudine, lamivudine, and nevirapine were detected in rivers in Kenya at μg L −1 level (Koreje et al, 2012). Biodegradation, photodegradation, and ozonation of oseltamivir and its carboxylates have been studied via bench-scale experiments as well as investigations in sewage treatment plants (Accinelli et al, 2007(Accinelli et al, , 2010aBartels and von Tumpling, 2008;Ghosh et al, 2010a,b;Goncalves et al, 2011;Mestankova et al, 2012;Sacca et al, 2009). Recently, Prasse et al (2011) revealed rapid biotransformation of acyclovir and penciclovir in activated sludge, whereas the transformation product of acyclovir, carboxy-acyclovir was found to be persistent and was detected in drinking water, groundwater, and surface water from 40 ng L −1 to 3.2 μg L −1 .…”

Section: Introductionmentioning

confidence: 99%

Profile and behavior of antiviral drugs in aquatic environments of the Pearl River Delta, China

Peng

Wang

Zhang

et al. 2014

Science of The Total Environment

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“…After administration, the drugs and their metabolites are excreted, carried away in sewers, passed through treatment facilities (Fick et al, 2007;Accinelli et al, 2007Accinelli et al, , 2010aAccinelli et al, , and 2010bSlater et al, 2011) and reached water bodies. The primary concern in this regard, is the potential emergence of drug resistant genes in human pathogens if the drugs remain in large concentrations in aquatic ecosystem for considerable periods (Fick et al, 2007;Singer et al, 2007;Accinelli et al, 2010a;Ghosh et al, 2010a and.…”

Section: Introductionmentioning

confidence: 99%

Antiviral Drugs Zanamivir and Oseltamivir Found in Wastewater and Surface Water in Osaka, Japan

Takanami

Ozaki

Giri

et al. 2012

J. of Wat. & Envir. Tech.

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Oseltamivir and zanamivir are the two most prescribed antiviral drugs against influenza in Japan. Oseltamivir and its metabolite are frequently detected in surface water bodies in Japan during the last few years particularly in seasonal influenza period posing a potential threat of emergence of drug-resistant genes in human pathogens. Despite the second largest use of zanamivir as an antiviral drug in Japan, its presence and fate in environmental waters is unknown until now. Accurate assessment on the presence and fates of these drugs in environmental waters is the very first step in countering the potential negative impact on human health. We have recently developed a novel solid-phase extraction (SPE) method for simultaneous recovery of oseltamivir and zanamivir in environmental waters. These antiviral drugs were quantified in Neya River water and a nearby conventional sewage treatment plant (STP) during the 2010/2011 seasonal influenza using the SPE method in this investigation. Oseltamivir and zanamivir concentrations in the river water and STP water samples are discussed and compared with those of the 2009/2010 pandemic influenza in this article. This successful simultaneous quantitation of zanamivir in wastewater and river water with high recovery ratios paves the way for its monitoring in environmental waters.

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Degradation of the antiviral drug oseltamivir carboxylate in surface water samples

Cited by 44 publications

References 26 publications

Effect of Oseltamivir Carboxylate Consumption on Emergence of Drug-Resistant H5N2 Avian Influenza Virus in Mallard Ducks

Effect of Oseltamivir Carboxylate Consumption on Emergence of Drug-Resistant H5N2 Avian Influenza Virus in Mallard Ducks

Profile and behavior of antiviral drugs in aquatic environments of the Pearl River Delta, China

Antiviral Drugs Zanamivir and Oseltamivir Found in Wastewater and Surface Water in Osaka, Japan

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