Degradation of the cytostatic etoposide in chlorinated water by liquid chromatography coupled to quadrupole-Orbitrap mass spectrometry: Identification and quantification of by-products in real water samples

Negreira, Noelia; Alda, Miren López de; Barceló, Damià

doi:10.1016/j.scitotenv.2014.10.097

Cited by 33 publications

(10 citation statements)

References 32 publications

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“…In previous studies, we demonstrated that etoposide induces the formation of giant cell shapes in in vitro human cancer cell lines, but we could not observe these phenomena in cultured normal cells or in vivo animal models. In addition, etoposide by‐products are detected in river and wastewater samples . Therefore, it is worth elucidating the cellular toxicological mechanisms of etoposide in a normal cell model in addition to cultured cancer cells.…”

Section: Introductionmentioning

confidence: 99%

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Toxicological evaluation of the topoisomerase inhibitor, etoposide, in the model animal Caenorhabditis elegans and 3T3‐L1 normal murine cells

Lee

Kim

Jung

et al. 2017

Environmental Toxicology

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Etoposide, a topoisomerase II inhibitor, has been widely used as a clinical anticancer drug to treat diverse cancer patients. Since not only rapidly dividing cancer cells but also the cells of normal human tissues and every living organism in environmental ecosystems have topoisomerases, it is crucial to study the toxicity of etoposide in other organisms in addition to cancer cells. In this study, we evaluated the toxicity of etoposide in both a soil nematode, Caenorhabditis elegans, and 3T3-L1 normal murine cells. Etoposide significantly retarded the growth, egg laying, and hatching in C. elegans. Etoposide also affected the reproductive gonad tissue, decreased the number of germ cells and induced abnormally enlarged nuclei in C. elegans. In addition, etoposide inhibited 3T3-L1 cell proliferation, with IC values of 37.8 ± 7.3 and 9.8 ± 1.8 μM after 24 and 48 hours of treatment, respectively, via the induction of cell cycle arrest at the G2/M phase and apoptotic cell death. Etoposide also induced nuclear enlargement in 3T3-L1 normal murine cells. The reproductive toxicity and abnormal nuclear morphological changes seemed to correlate with the adverse effects of etoposide. We suggest that these experimental platforms, i.e., the toxicological evaluation of both nematodes and 3T3-L1 cells, may be useful to study the mechanisms underlying the side effects of chemicals, including topoisomerase inhibitors.

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Section: Introductionmentioning

confidence: 99%

“…In addition, etoposide by-products are detected in river and wastewater samples. 11 Therefore, it is worth elucidating the cellular toxicological mechanisms of etoposide in a normal cell model in addition to cultured cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Toxicological evaluation of the topoisomerase inhibitor, etoposide, in the model animal Caenorhabditis elegans and 3T3‐L1 normal murine cells

Lee

Kim

Jung

et al. 2017

Environmental Toxicology

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“…As can be 343 seen, ERL followed a different behavior to that observed in ultrapure water, since after 1 h of 344 reaction ERL concentration decreased to around 40% with almost no further degradation 345 being observed afterwards. This is likely a consequence of the competition between ERL and 346 the organic matter of the sample for chlorine, as it has been already reported in previous 347 studies (Negreira et al 2012, Negreira et al 2015. Thus, most of chlorine is expected to be M A N U S C R I P T…”

Section: Erl Reactivity In Wastewater 337mentioning

confidence: 82%

“…In some cases, chlorination resulted in 60 TPs showing higher toxicity than the parent compounds (Bedner andMacCrehan 2006, 61 Canosa et al 2006). However, limited studies on the transformation of chemotherapeutic 62 drugs by chlorine have been reported to date (Negreira et al 2015, Roig et al 2014. 63 Currently, very scarce information is available on the occurrence and toxicological effects on 64 aquatic organisms of ERL (Besse et al 2012 TP-428B (Fig.…”

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confidence: 99%

Degradation of the anticancer drug erlotinib during water chlorination: Non-targeted approach for the identiﬁcation of transformation products

et al. 2015

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“…Thus, novel analytical screening tools using high-resolution mass spectrometry together with advanced software and workflows for data evaluation are developed [ 31 – 34 ] to address chemical contamination beyond well-known contaminants and priority pollutants and to characterise various water types for chemical profiles [ 35 ]. These non-target approaches are complemented by tailored analytical tools for compounds that might pose risks already at very low concentrations such as cytostatic drugs [ 36 ] and drugs of abuse [ 37 , 38 ].…”

Section: The Conceptual Frameworkmentioning

confidence: 99%

An expanded conceptual framework for solution-focused management of chemical pollution in European waters

et al. 2017

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BackgroundThis paper describes a conceptual framework for solutions-focused management of chemical contaminants built on novel and systematic approaches for identifying, quantifying and reducing risks of these substances.MethodsThe conceptual framework was developed in interaction with stakeholders representing relevant authorities and organisations responsible for managing environmental quality of water bodies. Stakeholder needs were compiled via a survey and dialogue. The content of the conceptual framework was thereafter developed with inputs from relevant scientific disciplines.ResultsThe conceptual framework consists of four access points: Chemicals, Environment, Abatement and Society, representing different aspects and approaches to engaging in the issue of chemical contamination of surface waters. It widens the scope for assessment and management of chemicals in comparison to a traditional (mostly) perchemical risk assessment approaches by including abatement- and societal approaches as optional solutions. The solution-focused approach implies an identification of abatement- and policy options upfront in the risk assessment process. The conceptual framework was designed for use in current and future chemical pollution assessments for the aquatic environment, including the specific challenges encountered in prioritising individual chemicals and mixtures, and is applicable for the development of approaches for safe chemical management in a broader sense. The four access points of the conceptual framework are interlinked by four key topics representing the main scientific challenges that need to be addressed, i.e.: identifying and prioritising hazardous chemicals at different scales; selecting relevant and efficient abatement options; providing regulatory support for chemicals management; predicting and prioritising future chemical risks. The conceptual framework aligns current challenges in the safe production and use of chemicals. The current state of knowledge and implementation of these challenges is described.ConclusionsThe use of the conceptual framework, and addressing the challenges, is intended to support: (1) forwarding sustainable use of chemicals, (2) identification of pollutants of priority concern for cost-effective management, (3) the selection of optimal abatement options and (4) the development and use of optimised legal and policy instruments.

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Degradation of the cytostatic etoposide in chlorinated water by liquid chromatography coupled to quadrupole-Orbitrap mass spectrometry: Identification and quantification of by-products in real water samples

Cited by 33 publications

References 32 publications

Toxicological evaluation of the topoisomerase inhibitor, etoposide, in the model animal Caenorhabditis elegans and 3T3‐L1 normal murine cells

Toxicological evaluation of the topoisomerase inhibitor, etoposide, in the model animal Caenorhabditis elegans and 3T3‐L1 normal murine cells

Degradation of the anticancer drug erlotinib during water chlorination: Non-targeted approach for the identiﬁcation of transformation products

An expanded conceptual framework for solution-focused management of chemical pollution in European waters

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