Degradation of the minor Fusarium mycotoxin beauvericin by intracellular enzymes of Saccharomyces cerevisiae

Meca, G.; Ritieni, Alberto; Zhou, Ting; Li, X.Z.; Mañes, Jordi

doi:10.1016/j.foodcont.2013.03.035

Cited by 7 publications

(4 citation statements)

References 23 publications

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“…A symbiotic yeast from the cigar beetle, Symbiotaphrina kochii , was reported to grow on a diversity of mycotoxins (DON, mycophenolic acid, OTA, sterigmatocystin, ZEA) as sole carbon sources (see also Supporting Information Table S1) , but these interesting results could not be replicated using DON and ZEA by Karlovsky et al . Beauvericin (BEA), an antibiotic and insecticidal cyclic depsipeptide produced by Beauveriana bassiana and certain Fusarium strains and considered a minor contaminant in cereal products, was found to be very effectively degradable by incubation with S. cerevisiae strains or by the intracellular raw enzymes of these in studies conducted both with a BEA model solution and contaminated corn flour . Studies concerning mycotoxin biodegradation by yeast strains are summarized in Supporting Information Table S1.…”

Section: Applications Of Yeastsmentioning

confidence: 99%

Mycotoxins – prevention and decontamination by yeasts

Pfliegler

Pusztahelyi

Pócsi

2015

J. Basic Microbiol.

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The application of yeasts has great potential in reducing the economic damage caused by toxigenic fungi in the agriculture. Some yeasts may act as biocontrol agents inhibiting the growth of filamentous fungi. These species may also gain importance in the preservation of agricultural products and in the reduction of their mycotoxin contamination, yet the extent of mycotoxin production in the presence of biocontrol agents is relatively less understood. The application of yeasts in various technological processes may have a direct inhibitory effect on the toxin production of certain molds, which is independent of their growth suppressing effect. Furthermore, several yeast species are capable of accumulating mycotoxins from agricultural products, thereby effectively decontaminating them. Probiotic yeasts or products containing yeast cell wall are also applied to counteract mycotoxicosis in livestock. Several yeast strains are also able to degrade toxins to less-toxic or even non-toxic substances. This intensively researched field would greatly benefit from a deeper knowledge on the genetic and molecular basis of toxin degradation. Moreover, yeasts and their biotechnologically important enzymes may exhibit sensitivity to certain mycotoxins, thereby mounting a considerable problem for the biotechnological industry. It is noted that yeasts are generally regarded as safe; however, there are reports of toxin degrading species that may cause human fungal infections. The aspects of yeast-mycotoxin relations with a brief consideration of strain improvement strategies and genetic modification for improved detoxifying properties and/or mycotoxin resistance are reviewed here.

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Section: Applications Of Yeastsmentioning

confidence: 99%

Mycotoxins – prevention and decontamination by yeasts

Pfliegler

Pusztahelyi

Pócsi

2015

J. Basic Microbiol.

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“…Benedetti et al (Benedetti et al, 2006) demonstrated that different bacterial isolates of maize ecosystem have the ability to degrade FB1, among of which, Sphingomonas sp. MTA144 (Meca et al, 2013), could encode aminotransferase FBI, showing strong fumonisin degrading activity . Hu et al reported that fengycin could inhibit the transcription of some key genes involved in the production of FB1 (Hu et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Improvement of Antagonistic Activity of Bacillus megaterium MHT6 against Fusarium moniliforme using He-Ne Laser Irradiation

Fu¹,

Feng²,

YaNan³

et al. 2015

IJAB

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Corn ear rot has been the most important disease of the world. It is mainly caused by Fusarium moniliforme which produce a number of mycotoxins including Fumonisin B1 (FB1). Aiming at supplying a potentially effective biological control agent against F. moniliforme, Bacillus megaterium MHT6 isolated from China, was tested for its antagonistic activity against F. moniliforme. Moreover, both antifungal activity and the active compound of strain MHT6 were tested and identified. In order to improve its antifungal activity, a random mutagenesis generated using He-Ne laser irradiation was applied on B. megaterium MHT6. After the mutation, one hundred bacterial colonies were obtained and their effects against F. moniliforme were assessed in a plate assay. Eight colonies (8%) exhibited higher inhibition activity as compared to the wild type MHT6. Among them, the mutant MHT 88 which showed the strongest antagonistic ability was selected out. Through bacterial motility assays, the mutant MHT88 showed stronger swarming motility than wild type MHT6. According to FPLC and MALDI-TOF-MS, the production of two main antagonistic lipopeptides such as surfactin and fengycin increased in mutant MHT88. Especially the surfactin, which can't be detected in the wild strain MHT6, was obviously observed in mutant. Moreover, the cell-free supernatant of the mutant MHT88 showed stronger capability in degrading FB1 compared to MHT6. This study provided a promising biological agent to inhibit F. moniliforme and suppress corn ear rot disease.

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“…Pseudomonas species have been identified to degrade aflatoxins and zearalenone . The yeast S. cerevisiae has been reported to degrade trichothecenes, enniatins, ochratoxin A, patulin and beauvericin . Abrunhosa et al reported that an enzyme from S. cerevisiae , carboxypeptidase Y, can hydrolyse ochratoxin A into ochratoxin alpha.…”

Section: Remediation Of Mycotoxins In Silagesmentioning

confidence: 99%

“…276,291,292 The yeast S. cerevisiae has been reported to degrade trichothecenes, enniatins, ochratoxin A, patulin and beauvericin. 154,273,289,293,294 Abrunhosa et al 295 reported that an enzyme from S. cerevisiae, carboxypeptidase Y, can hydrolyse ochratoxin A into ochratoxin alpha. It is highlighted in Table 4 if any degradation products were detected, since in some studies it is unclear whether the reduction of mycotoxin levels is caused by degradation, by binding to the microbial cell wall or by both mechanisms.…”

Section: Microbial Degradationmentioning

confidence: 99%

Occurrence, prevention and remediation of toxigenic fungi and mycotoxins in silage: a review

et al. 2016

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Ruminants are considered to be less sensitive towards mycotoxins than monogastric animals because rumen microbiota have mycotoxin-detoxifying capacities. Therefore the effect of mycotoxins towards ruminants has been studied to a lesser extent compared with monogastric animals. Worldwide, a high proportion of the ruminant diet consists of silages made of forage crops (i.e. all parts of the crop above the stubble are harvested). In practice, silages are often contaminated with multiple mycotoxins. Exposure to a cocktail of mycotoxins can hamper animal production and have severe health consequences. In this article the different aspects associated with mycotoxin contamination of silage are reviewed 'from seed to feed'. An overview is given on the occurrence of toxigenic fungal species and their concomitant mycotoxins in forage crops before and after ensiling. The mycotoxin load of visually non-mouldy samples and mouldy hot spots within the same silo is also compared. Subsequently, this review delves into different problem-solving strategies. A logical first step is prevention of mould growth and mycotoxin production in the field, during harvest and during ensiling. If prevention should fail, several remediation strategies are available. These are listed, mainly focusing on the possibilities of microbial degradation of mycotoxins in vivo in silage. © 2015 Society of Chemical Industry.

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Degradation of the minor Fusarium mycotoxin beauvericin by intracellular enzymes of Saccharomyces cerevisiae

Cited by 7 publications

References 23 publications

Mycotoxins – prevention and decontamination by yeasts

Mycotoxins – prevention and decontamination by yeasts

Improvement of Antagonistic Activity of Bacillus megaterium MHT6 against Fusarium moniliforme using He-Ne Laser Irradiation

Occurrence, prevention and remediation of toxigenic fungi and mycotoxins in silage: a review

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