Degradation profiles of poly(ethylene glycol)diacrylate (PEGDA)-based hydrogel nanoparticles

Stillman, Zachary; Jarai, Bader M; Raman, Nisha; Patel, Premal P.; Fromen, Catherine A.

doi:10.1039/c9py01206k

Cited by 56 publications

(55 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At 1 month and 2 months, the PEGDA/TCS, PEGDA/TCS/T-HNTs and PEGDA/TCS/T-HNTs/BMP2 hydrogels could be founded in the defect area while the residual hydrogels were almost degreased completely at 3 months. This results kept consist with the previous study that the degradation of PEGDA composites hydrogels depended on the weight ratio and crosslinking time [36][37][38].…”

Section: Histomorphometric Analysessupporting

confidence: 90%

Halloysites modified polyethylene glycol diacrylate/thiolated chitosan double network hydrogel combined with BMP-2 for rat skull regeneration

Sun

et al. 2021

Artificial Cells, Nanomedicine, and Biotechnology

View full text Add to dashboard Cite

Section: Histomorphometric Analysessupporting

confidence: 90%

Halloysites modified polyethylene glycol diacrylate/thiolated chitosan double network hydrogel combined with BMP-2 for rat skull regeneration

Sun

et al. 2021

Artificial Cells, Nanomedicine, and Biotechnology

View full text Add to dashboard Cite

“…PEGDA based hydrogel would undergo a bulk mode of degradation. [ 46 ] In bulk degradation, no significant change occurs in the physical size of the polymer network until it is almost fully degraded, but the fraction of polymer remaining in the hydrogel decreases over time. [ 44 ] Figure 2B shows that the microrobot swelled in the PBS environment for 20 d and lost some burrs, indicating that it takes longer to degrade the entire structure in a neutral environment.…”

Section: Resultsmentioning

confidence: 99%

Development of Magnet‐Driven and Image‐Guided Degradable Microrobots for the Precise Delivery of Engineered Stem Cells for Cancer Therapy

Wei

Liu

et al. 2020

Small

114

113

View full text Add to dashboard Cite

Precise delivery of therapeutic cells to the desired site in vivo is an emerging and promising cellular therapy in precision medicine. This paper presents the development of a magnet‐driven and image‐guided degradable microrobot that can precisely deliver engineered stem cells for orthotopic liver tumor treatment. The microrobot employs a burr‐like porous sphere structure and is made with a synthesized composite to fulfill degradability, mechanical strength, and magnetic actuation capability simultaneously. The cells can be spontaneously released from the microrobots on the basis of the optimized microrobot structure. The microrobot is actuated by a gradient magnetic field and guided by a unique photoacoustic imaging technology. In preclinical experiments on nude mice, microrobots carrying cells are injected via the portal vein and the released cells from the microrobots can inhibit the tumor growth greatly. This paper reveals for the first time of using degradable microrobots for precise delivery of therapeutic cells in vascular tissue and demonstrates its therapeutic effect in preclinical test.

show abstract

“…Furthermore, PEG was extensively exploited as a surface-coating polymer for DDS particles to prevent non-specifically proteins interaction, improve sterically stability, and prevent premature release of the incorporated therapeutic agents [ 66 , 67 , 68 ]. Surprisingly, the literature about its use as pH-sensitive coating for inorganic particles is still limited, however, few studies clearly proved the faster release of the encased biomolecules at acidic pH compared to neutral or basic conditions, when PEG was exploited as coating layer [ 69 , 70 ].…”

Section: Introductionmentioning

confidence: 99%

PEG-Coated Large Mesoporous Silicas as Smart Platform for Protein Delivery and Their Use in a Collagen-Based Formulation for 3D Printing

Niclot

Montalbano

Fiorilli

et al. 2021

IJMS

View full text Add to dashboard Cite

Silica-based mesoporous systems have gained great interest in drug delivery applications due to their excellent biocompatibility and high loading capability. However, these materials face challenges in terms of pore-size limitations since they are characterized by nanopores ranging between 6–8 nm and thus unsuitable to host large molecular weight molecules such as proteins, enzymes and growth factors (GFs). In this work, for an application in the field of bone regeneration, large-pore mesoporous silicas (LPMSs) were developed to vehicle large biomolecules and release them under a pH stimulus. Considering bone remodeling, the proposed pH-triggered mechanism aims to mimic the release of GFs encased in the bone matrix due to bone resorption by osteoclasts (OCs) and the associated pH drop. To this aim, LPMSs were prepared by using 1,3,5-trimethyl benzene (TMB) as a swelling agent and the synthesis solution was hydrothermally treated and the influence of different process temperatures and durations on the resulting mesostructure was investigated. The synthesized particles exhibited a cage-like mesoporous structure with accessible pores of diameter up to 23 nm. LPMSs produced at 140 °C for 24 h showed the best compromise in terms of specific surface area, pores size and shape and hence, were selected for further experiments. Horseradish peroxidase (HRP) was used as model protein to evaluate the ability of the LPMSs to adsorb and release large biomolecules. After HRP-loading, LPMSs were coated with a pH-responsive polymer, poly(ethylene glycol) (PEG), allowing the release of the incorporated biomolecules in response to a pH decrease, in an attempt to mimic GFs release in bone under the acidic pH generated by the resorption activity of OCs. The reported results proved that PEG-coated carriers released HRP more quickly in an acidic environment, due to the protonation of PEG at low pH that catalyzes polymer hydrolysis reaction. Our findings indicate that LPMSs could be used as carriers to deliver large biomolecules and prove the effectiveness of PEG as pH-responsive coating. Finally, as proof of concept, a collagen-based suspension was obtained by incorporating PEG-coated LPMS carriers into a type I collagen matrix with the aim of designing a hybrid formulation for 3D-printing of bone scaffolds.

show abstract

Degradation profiles of poly(ethylene glycol)diacrylate (PEGDA)-based hydrogel nanoparticles

Abstract: PEGDA-based nanogels have been used in numerous applications, but their degradation rates have not been explored. We determine the degradation rates for multiple formulations and demonstrate key differences in degradation rates relative to bulk gels.

Cited by 56 publications

References 46 publications

Halloysites modified polyethylene glycol diacrylate/thiolated chitosan double network hydrogel combined with BMP-2 for rat skull regeneration

Halloysites modified polyethylene glycol diacrylate/thiolated chitosan double network hydrogel combined with BMP-2 for rat skull regeneration

Development of Magnet‐Driven and Image‐Guided Degradable Microrobots for the Precise Delivery of Engineered Stem Cells for Cancer Therapy

PEG-Coated Large Mesoporous Silicas as Smart Platform for Protein Delivery and Their Use in a Collagen-Based Formulation for 3D Printing

Contact Info

Product

Resources

About