Degradation Studies of Triprolidine: Isolation, Characterization of Oxidative Degradation Products and Development of a Validated Stability Indicating Uhplc Method

Mone, Mahesh Kumar; Chandrasekhar, K. B.; Vyas, S. K.

doi:10.1080/10826076.2011.558651

Cited by 5 publications

(3 citation statements)

References 6 publications

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“…Few methods have been developed for the determination of triprolidine by high-pressure liquid chromatography (HPLC) [9] and spectrophotometric method [10]. Spectrophotometric and High performance liquid chromatographic method for the determination of TPH and its metabolite in biological samples using liquid chromatography [11], mass spectrometry [12], capillary Zone Electrophoresis Method for Quality Control Analysis of TPH with other drugs [13], degradation studies of TPH and stabilityindicating ultra-performance liquid chromatography method [14], new plastic membrane and carbon paste ion selective electrodes for the determination of TPH [15] were reported. TPH is usually administered in combination with dextromethorphan and/or phenylpropanolamine and also with paracetamol [16].…”

Section: Introductionmentioning

confidence: 99%

Validation of Sodium Nitroprusside in Visible Spectrophotometric Determination of Tripolidine Hydrochloride

Pvsr²,

Koti

2020

Innovare J Sci

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Objective: A simple and sensitive extractive visible spectrophotometric method is developed for the assay of triprolidine hydrochloride using sodium nitroprusside. Methods: Based on color development with amino groups, presence, which is basic, may be due to the formation of inner complex replacing H2O by the tertiary amino group present in the drug. Results: The colored products exhibit absorption λmax at 447 nm. Regression analysis of Beer–Lambert plots showed good correlation in the concentration ranges (40–240) μg/ml and correlation coefficients are 0.994. The Sandell’s sensitivities 2.6373×10−2 (1 mole cm−1) and molar absorptivity value are 1.1938×104 (g cm−2). Recovery studies are found to be 99.708–99.786. Conclusion: The method can be applied successfully for the estimation of the drug in the presence of other ingredients that are usually present in formulations.

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Section: Introductionmentioning

confidence: 99%

Validation of Sodium Nitroprusside in Visible Spectrophotometric Determination of Tripolidine Hydrochloride

Pvsr²,

Koti

2020

Innovare J Sci

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“…The reaction mixture was characterized by NMR without resorting to the usual practice of isolation. [14][15][16][17][18][19][20][21] …”

Section: Introductionmentioning

confidence: 99%

An NMR and Lc-MS Based Mixture Analysis Approach for Structural Elucidation of Antimicrobial Derivatives of Calophyllolide

Kalyanaraman

Ganesh

Kumar³

et al. 2012

Journal of Liquid Chromatography & Related Technologies

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& This account details the structural modification of Calophyllolide 1, using Ritter reaction with various nitriles to study the antimicrobial properties. Ritter reaction of calophyllolide results in a 1:1 mixture of two structurally related compounds 2 and 3. A stereogenic center was generated in the reaction products resulting in a racemic mixture. NMR mixture analysis strategy was employed for the chemical structural analysis. 2D NMR experiments such as gDQCOSY, gHSQC, gHMBC at 500 MHz, and LC-MS analysis allowed the complete assignment of 1 H and 13 C NMR spectra of mixture components 2 and 3. These results suggested an unusual carbon-carbon bond cleavage in the reaction product 3. Our effort highlights the NMR mixture analysis approach for characterization of mixture of compounds. An efficient and operationally simple chiral method by HPLC was developed to evaluate the enantiomer compositions. Based on the aforementioned spectral data, the compounds 2 and 3 were characterized as (E)-N-(5-methoxy-2,2-dimethyl-6-(2-methylbut-2-enoyl)-8-oxo-10-phenyl-2,8-dihydropyrano[2,3-f]chromen-4-yl)acetamide and N-(5-methoxy-2,2-dimethyl-8-oxo-10-phenyl-2,8-dihydropyrano[2,3-f]chromen-4-yl)acetamide, respectively. The possible mechanisms for these compounds formation were also proposed.

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“…Spectrophotometric and HPLC [11] determination of TPH and its metabolite in biological samples using liquid chromatographymass spectrometry [12]. Capillary Zone Electrophoresis Method for Quality Control Analysis of TPH with other drugs [13] degradation studies of TPH and Stability indicating Ultra Performance Liquid Chromatography method [14]. New plastic membrane and carbon paste ion elective electrodes for the determination of triprolidine [15].…”

mentioning

confidence: 99%

Untitled

2021

Indian J Adv Chem Sci

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Triprolidine hydrochloride (TPH) is chemically 2-[(1E)-1-(4methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl] pyridine (Figure 1). This is anti-allergic, Histamine H1 antagonist that blocks the action of endogenous histamine, which subsequently leads to temporary relief of negative symptoms brought on by histamine. It is used for the treatment of seasonal or perennial allergic rhinitis or non-allergic rhinitis, conjunctivitis, and mild urticaria and angioedema [1]. The most common side effects are sedation, dizziness, gastrointestinal disturbances, nausea, vomiting, and diarrhea. It may also produce blurred vision, dryness of mouth, tight of chest, blood disorders including agranulocytosis, and hemolytic anemia [2]. Literature survey revealed that few analytical methods have been reported for the determination of TPH in plasma using Thin-layer chromatography [3] simultaneous determination of TPH with other anti-histamines [4][5][6] other agents [7,8]. Few methods have been developed for the determination of triprolidine by highperformance liquid chromatography (HPLC) [9] and spectrophotometric method [10]. Spectrophotometric and HPLC [11] determination of TPH and its metabolite in biological samples using liquid chromatographymass spectrometry [12]. Capillary Zone Electrophoresis Method for Quality Control Analysis of TPH with other drugs [13] degradation studies of TPH and Stability indicating Ultra Performance Liquid Chromatography method [14]. New plastic membrane and carbon paste ion elective electrodes for the determination of triprolidine [15]. TPH is usually administered in combination with dextromethorphan and/or phenylpropanolamine and also with paracetamol [16].

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Degradation Studies of Triprolidine: Isolation, Characterization of Oxidative Degradation Products and Development of a Validated Stability Indicating Uhplc Method

Cited by 5 publications

References 6 publications

Validation of Sodium Nitroprusside in Visible Spectrophotometric Determination of Tripolidine Hydrochloride

Validation of Sodium Nitroprusside in Visible Spectrophotometric Determination of Tripolidine Hydrochloride

An NMR and Lc-MS Based Mixture Analysis Approach for Structural Elucidation of Antimicrobial Derivatives of Calophyllolide

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