Degradation studies on segmented polyurethanes prepared with HMDI, PCL and different chain extenders

Chan-Chan, Lerma H.; Solis-Correa, R.; Vargas-Coronado, Rossana Faride; Cervantes‐Uc, José Manuel; Cauich-Rodríguez, J.V.; Quintana, P.; Bartolo‐Pérez, P.

doi:10.1016/j.actbio.2009.12.010

Cited by 131 publications

(79 citation statements)

References 39 publications

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“…In other words, depends upon the reagents used during synthesis of the PUU, that is, the type of chain extender, the type of isocyanate or polyol, and/or the synthesis conditions. The findings of this study regarding the degradation kinetics of PUU are similar to those presented in the scientific literature 22, 23…”

Section: Resultssupporting

confidence: 89%

Indirect three‐dimensional printing: A method for fabricating polyurethane‐urea based cardiac scaffolds

Hernández‐Córdova

Mathew

Balint

et al. 2016

J. Biomed. Mater. Res.

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Biomaterial scaffolds are a key part of cardiac tissue engineering therapies. The group has recently synthesized a novel polycaprolactone based polyurethane‐urea copolymer that showed improved mechanical properties compared with its previously published counterparts. The aim of this study was to explore whether indirect three‐dimensional (3D) printing could provide a means to fabricate this novel, biodegradable polymer into a scaffold suitable for cardiac tissue engineering. Indirect 3D printing was carried out through printing water dissolvable poly(vinyl alcohol) porogens in three different sizes based on a wood‐stack model, into which a polyurethane‐urea solution was pressure injected. The porogens were removed, leading to soft polyurethane‐urea scaffolds with regular tubular pores. The scaffolds were characterized for their compressive and tensile mechanical behavior; and their degradation was monitored for 12 months under simulated physiological conditions. Their compatibility with cardiac myocytes and performance in novel cardiac engineering‐related techniques, such as aggregate seeding and bi‐directional perfusion, was also assessed. The scaffolds were found to have mechanical properties similar to cardiac tissue, and good biocompatibility with cardiac myocytes. Furthermore, the incorporated cells preserved their phenotype with no signs of de‐differentiation. The constructs worked well in perfusion experiments, showing enhanced seeding efficiency. © 2016 The Authors Journal of Biomedical Materials Research Part A Published by Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 1912–1921, 2016.

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Section: Resultssupporting

confidence: 89%

Indirect three‐dimensional printing: A method for fabricating polyurethane‐urea based cardiac scaffolds

Hernández‐Córdova

Mathew

Balint

et al. 2016

J. Biomed. Mater. Res.

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“…The majority of isocyanates used such as toluene-2,4-diisocyanate, isophorone diisocyanate, and 4,4-methylene diphenyl diisocyanate are aromatic in structure while aliphatic isocyanates, such as hexamethylene diisocyanate (HMDI), are also used (Teo et al, 1997, Chan-Chan et al, 2010, Prisacariu, 2011, Chung and Washburn, 2012, Zhang et al, 2015. Polyols are usually the more flexible of the two components which allows the formation of flexible PU materials and usually consist of polyesters, polyethers, or glycols such as polyethylene glycol (PEG), 1,4-butanediol, and polypropylene glycol (PPG) (Grassie and Zulfiqar, 1978;Wen et al, 2001;Oprea, 2010;Nozaki et al, 2017).…”

Section: Polyurethane (Pu)mentioning

confidence: 99%

The Effect of Plant Source on the Properties of Lignin-Based Polyurethanes

2018

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This work increases our understanding of the effect of plant source on the mechanical and morphological properties of lignin-based polyurethanes (PUs). Lignin is a polymer that is synthesized inside the plant cell wall and can be used as a polyol to synthesize PUs. The specific aromatic structure of the lignin is heavily reliant on the plant source from which it is extracted. These results show that the mechanical properties of ligninbased PUs differ based on lignin's plant source. The morphology of lignin-based PUs was examined using atomic force microscopy and scanning electron microscopy and the mechanical properties of lignin-based PU samples were measured using dynamic mechanical analysis and shore hardness (Type A). The thermal analysis and morphology studies demonstrate that all PUs prepared form a multiphase morphology. In these PUs, better mixing was observed in the wheat straw lignin PU samples leading to higher moduli than in the hardwood lignin and softwood lignin PUs whose morphology was dominated by larger aggregates. Independent of the type of the lignin used, increasing the fraction of lignin increased the rigidity of PU. Among the different types of lignin studied, PU with wheat straw soda lignin exhibited storage moduli ~2-fold higher than those of PUs incorporating other lignins. This study also showed that during synthesis all hydroxyl groups in the lignin are not available to react with isocyanates, which alters the number of cross-links formed within the PU and impacts the mechanical properties of the material.

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“…Todos los ensayos fueron realizados por triplicado. El porcentaje de viabilidad se calculó con la ecuación 3: 36 (3) Donde Abs muestra es la absorbancia de las células luego de ser tratadas con la muestra y Abs control es la absorbancia de las células sin muestra.…”

Section: Citotoxicidad In Vitro Por Contacto Directo De Los Pusunclassified

“…1 Su carácter de copolímero en bloque los dota de una amplia versatilidad en términos de adaptación de sus propiedades físicas y compatibilidad. [2][3][4][5][6][7] Es así como los PUs son interesantes para usos internos (in vivo), especialmente en aplicaciones a corto plazo, como catéteres o implantes. De igual forma, son interesantes para aplicaciones de uso externo (in vitro), como por ejemplo los sistemas de liberación controlada de medicamentos.…”

Section: Introductionunclassified

Actividad antibacteriana, degradación hidrolítica y microbiana y citotoxicidad in vitro de poliuretanos sintetizados con polioles derivados del aceite de higuerilla

Uscátegui¹,

Díaz²,

Valero³

2016

Quim. Nova

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ANTIBACTERIAL ACTIVITY, HYDROLYTIC AND MICROBIAL DEGRADATION AND in vitro CYTOTOXICITY OF POLYURETHANE SYNTHESIZED WITH POLYOLS FROM CASTOR OIL DERIVATIVES. Biological activities from polyurethanes (PUs) synthesized from polyols (derived from castor oil) and isophorone diisocyanate were evaluated. In vitro degradability was evaluated by phosphate buffered saline (PBS) and antibacterial degradation with Escherichia coli and Pseudomonas aeruginosa. The biocompatibility was analyzed by: i) the antimicrobial activity against E. coli, S. aureus and P. aeruginosa, and ii) in vitro cytotoxicity assays using mouse embryonic fibroblast cell line L-929 in direct contact with the PUs and with NIH/3T3 cells in indirect contact with the PUs degradation products. PUs with polyol P1 (2,64% molar relation of pentaerythritol and castor oil) was the material with better biodegradation properties: 1.125±0.110% in 72 h by PBS at 100 °C. In general, all materials were degraded up to 1.000±0.223% and 2.251±0.010% in 72 h by E. coli and P. aeruginosa, respectively. On the other hand, it was determined a close relationship between functionality of polyol and bacterial inhibition. The antibacterial effect of the PUs decreased by 67% for E. coli, 55% for S. aureus and 56% for P. aeruginosa after 24 h. Chemical modification of castor oil did not generate a cytotoxic effect on the tested cell lines. The evaluated materials are suggested as candidates to obtain biomaterials due to their mechanical properties and biocompatibility presented in untransformed cells.Keywords: castor oil; polycaprolactone; cytotoxicity; degradability; biomedical applications. INTRODUCCIÓNLos poliuretanos (PUs) representan una popular e importante parte de productos industriales que se caracterizan por tener buenas propiedades de flexibilidad, elevada resistencia al impacto y durabilidad, características que lo convierten en polímeros con múltiples aplicaciones. 1 Su carácter de copolímero en bloque los dota de una amplia versatilidad en términos de adaptación de sus propiedades físicas y compatibilidad. 2-7 Es así como los PUs son interesantes para usos internos (in vivo), especialmente en aplicaciones a corto plazo, como catéteres o implantes. De igual forma, son interesantes para aplicaciones de uso externo (in vitro), como por ejemplo los sistemas de liberación controlada de medicamentos. 8 De esta forma los PUs son polímeros sintéticos biocompatibles que se emplean en dispositivos médicos y en aplicaciones de ingeniería de tejidos. Los PUs empleados como materiales biomédicos deben cumplir con las propiedades mecánicas para la aplicación destino, deben ser no tóxicos, ser biodegradables de acuerdo con la función a cumplir y deben ser biocompatibles. 9,10 Se han utilizado estrategias para mejorar falencias de estos materiales como las propiedades de fatiga, control de la degradación, incremento de proliferación celular, entre otros. Algunas de estas estrategias consisten en modificar la superficie de los PUs por medio de procesos físicos o químicos. 11 La eval...

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Degradation studies on segmented polyurethanes prepared with HMDI, PCL and different chain extenders

Cited by 131 publications

References 39 publications

Indirect three‐dimensional printing: A method for fabricating polyurethane‐urea based cardiac scaffolds

Indirect three‐dimensional printing: A method for fabricating polyurethane‐urea based cardiac scaffolds

The Effect of Plant Source on the Properties of Lignin-Based Polyurethanes

Actividad antibacteriana, degradación hidrolítica y microbiana y citotoxicidad in vitro de poliuretanos sintetizados con polioles derivados del aceite de higuerilla

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