1965
DOI: 10.2337/diab.14.8.493
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Degranulation of Beta Cells and Loss of Pancreatic Insulin after Infusions of Insulin Antibody or Glucose

Abstract: The experimental findings reported here may have some implications concerning the secretion of insulin under physiological conditions. They would suggest that at a given level of blood glucose, the rate of insulin loss from the beta cells may be larger when the level of insulin in the blood is low. They would suggest too that beta cells lining the proximal portions of the islet sinusoids would secrete to a greater degree than beta cells lining the more distal parts of the sinusoids.In previous experiments repo… Show more

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Cited by 37 publications
(14 citation statements)
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“…Although the mechanism for this increase is unknown, it may reflect the progressive reduction of hyperglycaemia during the gliclazide treatment. This is supported by the observations that islets of normal rats made hyperglycaemic for a long period show markedly degranulated B cells and a low insulin content [34,35] such a pattern being rapidly reversible with the return to normoglycaemia [35]. It has also been postulated that hyperglycaemia in vivo has a long-term effect of suppressing insulin synthesis [36].…”
Section: Discussionsupporting
confidence: 65%
“…Although the mechanism for this increase is unknown, it may reflect the progressive reduction of hyperglycaemia during the gliclazide treatment. This is supported by the observations that islets of normal rats made hyperglycaemic for a long period show markedly degranulated B cells and a low insulin content [34,35] such a pattern being rapidly reversible with the return to normoglycaemia [35]. It has also been postulated that hyperglycaemia in vivo has a long-term effect of suppressing insulin synthesis [36].…”
Section: Discussionsupporting
confidence: 65%
“…These results show that exogenous insulin infused for a prolonged period inhibits endogenous insulin secretion. It remains to be established whether the feedback mechanism is direct (Sodoyez et al, 1969;Loubatieres et al, 1968;Frerichs et al, 1965) or indirect (Logothetopoulos et al, 1965;Malaisse & Malaisse-Lagae, 1969).…”
Section: Discussionmentioning
confidence: 99%
“…Although there have been several reports suggesting a direct feedback inhibition of insulin by insulin (Best & Haist, 1941;Sodoyez et al, 1964;Logothetopoulos et al, 1965;Sodoyez et al, 1969;Chu & Goodner, 1968;Hellman & Lernmark, 1969;Iversen & Miles, 1971;Hahn & Micheal, 1971) some workers found no inhibition (Grodsky et al, 1968b;Malaisse et al, 1967;Sando et al, 1970) However, in man, it has not yet been documented whether insulin secretion is influenced by the blood level of insulin. In order to investigate any presence of a feedback mechanism of insulin secretion, the effect of prior infusion of bonito insulin upon glucose-induced insulin secretion in man was studied.…”
mentioning
confidence: 99%
“…The animals were killed 5 h after the first injection or initiation of the infusion (Wright, 1959;Cunningham et aI., 1963;Gregor et al, 1963;Logothetopoulos et al, 1965;Lacy and Wright, 1965 ;Wright et al, 1966).…”
Section: Guinea Pig Antiinsuliu Seramentioning
confidence: 99%