Degranulation of eosinophilic granule cells in neurofibromas and gastrointestinal tract in the bicolor damselfish

Schmale, Michael C.; Vicha, Dale; Cacal, Saul M.

doi:10.1016/j.fsi.2003.12.002

Cited by 28 publications

(25 citation statements)

References 36 publications

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“…Apparently, most teleost fish exhibit these cells in various organs, with properties similar to mast cells of mammals (Dezfuli et al, 2008). Several studies indicate that these cells degranulate in response to pathogens, thus affecting vascular permeability and suggesting that their products act in the induction of the host's inflammatory response: vasodilatation, recruitment of neutrophils, migration and activation of macrophages, and production of neuromodulators, enzymes, or antimicrobial peptides (Dezfuli et al, 2000(Dezfuli et al, , 2008Schmale et al, 2004;Murray et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Prevalence, Intensity, and Abundance of Infection and Pathogenesis Caused by Diphyllobothriosis in Vulnerable, Native Fish and Introduced Trout in Lake Panguipulli, Chile

Torres

Leyan

Puga

2012

Journal of Wildlife Diseases

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ABSTRACT:Diphyllobothriosis in fish from freshwater ecosystems in southern Chile was first reported in 1949. Infection by plerocercoids of Diphyllobothrium latum and Diphyllobothrium dendriticum occurs in introduced trout (Oncorhynchus mykiss) and native fish. We determined the prevalence, mean intensity, and mean abundance of seasonal infection and tissue damage produced by Diphyllobothrium spp. in native fish (Percichthys trucha, Odontesthes mauleanum, and Basilichthys australis) and introduced trout (O. mykiss) from Lake Panguipulli, Chile. Prevalence, mean intensity, and mean abundance of D. latum infection were significantly greater in trout than they were in native fish. Prevalence and mean abundance were similar in O. mauleanum and P. trucha, but they were greater than those in B. australis. Prevalence and abundance were similar among seasons between sexes for the four hosts. For all host species, except P. trucha, there was a statistically significant positive correlation between host length and the abundance of plerocercoids. Infections in muscle tissue were present in 61% of trout compared with 23% in O. mauleanum and 12% in P. trucha, suggesting a greater risk for human infection when consuming trout. In general, prevalence of infection by D. dendriticum was lower than was D. latum prevalence. Encapsulation of plerocercoids was common and severe in 71% of the trout examined. Only slight encapsulation of plerocercoids was found in the native O. mauleanum, and no encapsulation was observed in P. trucha or B. australis. The greater concentration of plerocercoids in the walls of the digestive tract of trout suggests a more-rapid immune response in trout than in native fish. The low frequency of encapsulation of plerocercoids in native fish would mean greater tissue damage in the natives than that observed in the trout because they are free to migrate among the viscera, potentially endangering these native fish populations in regions where Diphyllobothrium spp. are endemic.

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Section: Discussionmentioning

confidence: 99%

Prevalence, Intensity, and Abundance of Infection and Pathogenesis Caused by Diphyllobothriosis in Vulnerable, Native Fish and Introduced Trout in Lake Panguipulli, Chile

Torres

Leyan

Puga

2012

Journal of Wildlife Diseases

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“…The specific role of mast cells in reaction to pathogen challenge has been sought for some time. Considerable descriptive records exist showing how these cells degranulate in response to exposure to a variety of pathogens or known degranulating agents (Powell et al, 1993;Reite, 1997;Paulsen et al, 2001;Schmale et al, 2004;Dezfuli et al, 2008). The functional similarity of the fish mast cells to mammalian mast cells has stimulated considerable research into determining the content of the cytoplasmic granules and hence an understanding of cellular function.…”

Section: Discussionmentioning

confidence: 99%

The inflammatory response of fish to helminth parasites

Dezfuli¹,

Lui²,

Boldrini

et al. 2008

Parasite

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Summary :Fish serve as a good model for studying vertebrate immune systems because they have a relatively simple system. Descriptions of histopathological effects of helminth parasites on fish are few and far between with limited observations made on the identification of the inflammatory cells involved in the host reaction. Recently, two cell types found within teleosts received a great deal of attention, namely mast cells and rodlet cells. Fish mast cells also known as eosinophilic granule cells, are morphologically and functionally similar to their mammalian counterparts. Acute tissue damage causes mast cells degranulation and the release of mediators of inflammation, whereas, an increase in the number of these cells is usually found in chronically inflamed tissues. Rodlet cells, however, are exclusive to fish and are characterized by a distinct cell cortex and conspicuous inclusions, called rodlets, which accounts for their name. Piscidin has also been encountered within rodlet cells. As important cell types within the immune system of fish, both mast cells and rodlet cells have been seen to increase in number in infected fish, notably at the sites of pathogen attachment or infection. The present survey will provide data from studies with the light microscope on the response of mast cells and rodlet cells in a range of fish species (Anguilla anguilla, Oncorhynchus mykiss, Salmo trutta, Coregonus lavaretus) infected with a range of different parasite genera including representatives from the Digenea, Cestoda, Nematoda and Acanthocephala. frino et al., 1999; Dezfuli et al., 2000a Dezfuli et al., , 2002a Dezfuli et al., , b, 2003b Bosi et al., 2005). The cellular involvement in the inflammatory response in teleostean fish could be biphasic, initiating with an influx of neutrophils followed by latter arrival of monocytes/macrophages (Reite & Evensen, 2006). In fish, two inflammatory cell types, namely mast cells and rodlet cells (RCs) are closely linked to other piscine inflammatory cells (Reite, 1997; Dezfuli et al., 2000b). Mast cells are found mainly in the connective tissue distributed throughput the body, and are more frequently found in tegumentary, urinary, respiratory, reproductive and gastrointestinal systems (Rocha & Chiarini-Garcia, 2007). These cells have been noticed in all vertebrates, fish (Roberts et al., 1971;Reite, 1996), amphibians (Chiu & Lagunoff, 1972), reptiles (Sottovia-Filho & Taga, 1973), birds (Selye, 1965) and mammals (Galli, 1990; Chiarini-Garcia & Pereira, 1999). Nevertheless, there is some controversy in the literature about mast cells existence in fish despite the fact that early reviews of the mast cells left little doubt that this cell type was present in all groups of vertebrates (Reite & Evensen, 2006). In fish parasitized with helminths, greater number of mast cells was noticed in site of infection (Reite, 1997; Dezfuli et al., 2000b;Reite & Evensen, 2006). Regarding rodlet cells (RCs), they are characterized by a thick fibrous capsule, a basal nucleus, and conspicuous in...

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“…Las CG/CGE en peces están asociadas con los mecanismos de respuesta a procesos infecciosos de ) las observaciones realizadas en el presente estudio apoyan esta hipótesis, debido a que la morfología de las CG/CGE observadas (en especial el citoplasma lleno de gránulos), junto con su distribución en los tejidos y sus propiedades de tinción coinciden con estos reportes. Numerosos estudios reportan el aumento de las CGE en los tejidos después de la exposición a agentes inmunotóxicos (Dezfuli & Giari 2008, Schmale et al 2004). En este trabajo aunque no se realizaron conteos del número de CGE presentes en el epitelio olfativo de los diferentes tratamientos, de manera cualitativa se observó un aumento considerable en el número de CGE en el tratamiento 3 (1 mg/l) con respecto al T2 (0.1 mg/l), lo cual sugiere que la concentración de 1 mg/l de Roundup ® Activo puede generar un grado mayor de daño en el epitelio olfativo.…”

Section: Discussionunclassified

Alteraciones Histopatológicas de los Bulbos Olfatorios de Cachama Blanca ante una Presentación Comercial de Glifosato: (Roundup® Activo)

Cortes

Gómez-Ramírez

Giraldo

2016

Rev. Fac. Cienc. Básicas

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RESUMENEl glifosato, en su presentación comercial Roundup ® Activo, es un herbicida de amplio uso en Colombia.Se ha reportado que en Piaractus brachypomus este herbicida puede generar alteraciones a nivel cerebral incluyendo los bulbos olfatorios y se plantea que una de sus posibles vías de entrada al sistema nervioso central es el sistema olfativo. Por tal motivo, se pretende determinar las alteraciones histopatológicas del Roundup ® Activo en los bulbos olfatorios de P. brachypomus. Se utilizaron 45 alevinos de P. brachypomus tratados con tres dosis (0, 0.1 y 1 mg/l) de Roundup ® Activo durante un mes. Trascurrido un mes los cerebros fueron disectados, fijados y procesados para procesamiento en microscopia óptica de alta resolución. El tratamiento de 0 mg/l de Roundup ® Activo no presentó alteraciones histopatológicas en las diferentes células de los núcleos neuronales se observaron normales. No obstante, los individuos expuestos a 0.1 y 1 mg/l de Roundup ® Activo presentaron células granulares que se identificaron principalmente asociadas a los vasos sanguíneos de la pía madre del bulbo olfativo. La presencia de células granulares en los bulbos olfatorios es un indicativo de daños a nivel tisular. Teniendo en cuenta que el sistema olfativo está directamente implicado procesos vitales para los peces como la alimentación, la reproducción y el reconocimiento intra e inter específico; exposiciones prolongadas a este herbicida podrían afectar el adecuado desarrollo de P. brachypomus y su interacción con el ambiente.

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Degranulation of eosinophilic granule cells in neurofibromas and gastrointestinal tract in the bicolor damselfish

Cited by 28 publications

References 36 publications

Prevalence, Intensity, and Abundance of Infection and Pathogenesis Caused by Diphyllobothriosis in Vulnerable, Native Fish and Introduced Trout in Lake Panguipulli, Chile

Prevalence, Intensity, and Abundance of Infection and Pathogenesis Caused by Diphyllobothriosis in Vulnerable, Native Fish and Introduced Trout in Lake Panguipulli, Chile

The inflammatory response of fish to helminth parasites

Alteraciones Histopatológicas de los Bulbos Olfatorios de Cachama Blanca ante una Presentación Comercial de Glifosato: (Roundup® Activo)

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