Degree of Bronchial Metaplasia in Heavy Smokers and Its Regression After Treatment With a Retinoid

Gouveia, J; Hercend, Thierry; Lemaigre, G; Mathé, G; Gros, François; Santelli, G; Homasson, J.-P.; Angebault, M; Lededente, A; Parrot, R.; Gaillard, J; Bonniot, Jean-Pierre; Marsac, J; Prétet, S

doi:10.1016/s0140-6736(82)92623-x

Cited by 91 publications

(21 citation statements)

References 7 publications

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“…Such changes (decrease of ciliated cells with simultaneous increase of the secretion) are noted for smokers (Gouveia et al, 1982;Mathe et al, 1983) and cause a reduction of the mucociliary clearance. This reduction of the mucociliary clearance, associated with an increased adsorption of the respiratory syncytial virus (RSV; Donelly, 1996), could explain the extraordinarily high morbidity and mortality for respiratory infections of children with vitamin A deficiency in developing countries (Sommer, 1993).…”

Section: Protecting Factorsmentioning

confidence: 91%

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Meat and cancer: meat as a component of a healthy diet

Biesalski

2002

Eur J Clin Nutr

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Based on epidemiological studies it is assumed that meat, especially red meat, enhances risk for cancer, particulary of the colon, breast and prostate. Meat and meat products are important sources of protein, some micronutrients and fat. High fat intake has been blamed for correlation with different diseases, including cancer. Meat protein is reported to contribute to cancer formation. However, meat, including liver, is not only composed of fat and protein, it contains essential nutrients which appear exclusively in meat (vitamin A, vitamin B 12 ) and micronutrients for which meat is the major source because of either high concentrations or better bioavailability (folate, selenium, zinc). In particular, vitamin A, folate and selenium are reported to be cancer-preventive, with respect to colon, breast and prostate cancer. Taken together, meat consists of a few, not clearly defined cancer-promoting and a lot of cancer-protecting factors. The latter can be optimized by a diet containing fruit and vegetables, which contain hundreds of more or less proven bioactive constituents, many of them showing antioxidative and anticarcinogenic effects in vitro.

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Section: Protecting Factorsmentioning

confidence: 91%

“…Squamous metaplasia of the bronchial mucosa, which occurs in smokers in spite of a sufficient supply with vitamin A as an effect of inhalative noxae, could also be reversed through systemic application of high retinoid concentrations in vitro (Lasnitzky & Bollag, 1982 and in humans in vivo (Gouveia et al, 1982;Mathe et al, 1983).…”

Section: Protecting Factorsmentioning

confidence: 99%

Meat and cancer: meat as a component of a healthy diet

Biesalski

2002

Eur J Clin Nutr

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“…These conclusions were supported by the chemopreventive studies showing a regression of preneo plastic lesions following local or systemic administration of ascorbic acid (De Cosse et al 1975, Bussey et al 1982 or retinoids (Ryssel et al 1971, Koch 1978, Bollag 1979, Gouveia et al 1982. The anticarcinogens or antimutagens may exert their effect by trapping the ultimate carcinogens, acting as electron scavengers for free radicals or interfering with the activation of pre-carcinogens into their reactive electrophilic forms Acton 1979, Stich et al 1984).…”

Section: B Chronic Experiments On Bone Marrow Chromosomesmentioning

confidence: 93%

Effects of vitamin C and vitamin A on post chromosomal aberration in vivo induced by metanil yellow and zinc chloride.

Giri

Bandyopadhyay²,

Mukherjee

et al. 1988

CYTOLOGIA

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“…Such a deficit results in a loss of cilia, an increase of secreting cells and finally the formation of squamous metaplasia (Chytil, 1985;Stofft et al, 1992). Such changes (decrease of ciliated cells with simultaneous increase of the secretion) are noted among smokers (Gouveia et al, 1982;Mathe et al, 1983) and cause a reduction of the mucociliary clearance. This reduction of the mucociliary clearance, associated with an increased adsorption of the respiratory syncytial virus (RSV)…”

Section: Protecting Micronutrients In Meat With Respect To Cancermentioning

confidence: 99%

“…Biesalski (2005)). Squamous metaplasia of the bronchial mucosa, which occurs in smokers in spite of a sufficient supply with vitamin A as an effect of inhalative noxae could also be reversed through systemic application of high retinoid concentrations in vitro (Lasnitzki and Bollag, 1987) and in humans in vivo (Gouveia et al, 1982;Mathe et al, 1983).…”

Section: Protecting Micronutrients In Meat With Respect To Cancermentioning

confidence: 99%

‘Mealthy’ food: meat as a healthy and valuable source of micronutrients

Nöhr

Biesalski

2007

Animal

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Over the last two or three decades meat and especially liver have been looked upon as unhealthy food with high fat content and carcinogenic potential. In addition, its content of highly valuable micronutrients has mostly been ignored. As a result, the mean uptake and serum levels of several micronutrients in the population are below the recommended levels. In the meantime, the contamination of liver with heavy metals and other contaminants has fallen far below the allowed thresholds and sometimes even below the detection limit while its content of micronutrients like iron, folate, selenium or zinc are still high. As a further advantage, the bioavailability of many micronutrients often is better from meat and liver then from plant sources. Considering these advantages and the low content of contaminants in meat and liver leads us to propose that meat -including livershould be a regular part of a mixed and balanced healthy diet along with vegetables and fruits as the major components to ensure an optimal supply of micronutrients.

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Degree of Bronchial Metaplasia in Heavy Smokers and Its Regression After Treatment With a Retinoid

Cited by 91 publications

References 7 publications

Meat and cancer: meat as a component of a healthy diet

Meat and cancer: meat as a component of a healthy diet

Effects of vitamin C and vitamin A on post chromosomal aberration in vivo induced by metanil yellow and zinc chloride.

‘Mealthy’ food: meat as a healthy and valuable source of micronutrients

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