Degree of Gastric Mucosal Atrophy Correlated Well with Gastric Cancer Occurrence in Patients with <i>Helicobacter pylori</i>-eradicated Status

Abstract

Objective This study was performed to clarify the association of the degree of gastric mucosal atrophy (GMA) with the occurrence of gastric cancer in patients with Helicobacter pylori-eradicated status. Subjects and Methods The subjects were 3,058 patients (2,035 men, 1,023 women; mean age 57.9 ± 9.5 years old) with H. pylori eradication who underwent esophago-gastroduodenal endoscopy examinations as part of medical checkups conducted between April 2013 and March 2022. The gender, age at eradication, time since eradication, usage of anti-secretory drugs, degree of endoscopic GMA, and FGP prevalence were compared between subjects with and without gastric cancer occurrence. Results Gastric cancer was newly detected in 26 subjects (0.85%) during the study period, with an older age at H. pylori eradication and severe grade of endoscopic GMA being significant risk factors for its occurrence. The gender, smoking history, and usage of anti-secretory drugs were not significantly different between subjects with and without gastric cancer occurrence. A Cox regression analysis showed that an older age at eradication and the degree of GMA were risk factors significantly related to occurrence. Furthermore, the degree of GMA was inversely correlated with FGP development, and gastric cancer was not detected in 467 subjects with FGP prevalence. Conclusion An older age at the time of H. pylori eradication and the degree of GMA are significant risk factors for gastric cancer occurrence in H. pylori-eradicated patients. The FGP prevalence in subjects with H. pylori eradication was inversely associated with GMA, suggesting it was negatively related with gastric cancer occurrence.

Analysis of risk factors for postoperative bleeding and polyp recurrence in adolescents with gastric polyps treated with endoscopic mucosal resection: a retrospective cohort study

“…Based on their number, gastric polyps can be classified as multiple polyps or single polyps; based on their morphology, polyp types can be classified as flat, pedunculated, subpedunculated, or sessile (5); based on their pathological type, polyps can be classified as adenomatous polyps and non-adenomatous polyps, and non-adenomatous polyps can be further classified as inflammatory polyps, hyperplastic polyps, and gastric fundic gland polyps. Among them, gastric adenomatous polyps are considered precancerous lesions, and with a carcinogenicity rate as high as 10-20%, these polyps have a great effect on human health, and if left untreated, may recur or even gradually become cancerous in the long-term (6). In addition, gastric polyps become more cancerous as the polyp size and number increase (7).…”