Degree of neuronal activation following FG-7142 changes across regions during development

Lyss, Pamela J; Andersen, Susan; LeBlanc, Celeste J.; Teicher, Martin H.

doi:10.1016/s0165-3806(99)00069-3

Cited by 36 publications

(29 citation statements)

References 17 publications

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“…Stress-mediated changes within the dopamine system have a wider magnitude of effect during development than adulthood. Before puberty, the beta-carboline FG-7142, an agent that has stress-like effects on dopamine [31,50], increases neuronal activation (indicated by c-fos immunoreactivity changes) in accumbens to a greater extent than the adult-typical response of predominant prefrontal cortex activation [146]; these data are shown in Fig. 3.…”

Section: Age-dependent Differences In Pharmacological Sensitivity To mentioning

confidence: 93%

“…However, as described in Section 3.3 above, stress has more widespread effects earlier in development (Fig. 3) [146]. As a result, early stress can imprint on the subcortical dopamine systems to a greater extent within this prepubertal window than post-pubertal exposure to stress.…”

Section: Regional Selectivity Of Insultmentioning

confidence: 96%

“…The determination of set points for future regulation and pharmacological sensitivity occurs pre-pubertally and influences the overall tone of the mature neurotransmitter system. For example, dopamine pharmacology changes during the transitions from preweaning to puberty to adulthood in the rat [8,11,146].…”

Section: Age-dependent Differences In Pharmacological Sensitivity To mentioning

confidence: 99%

“…3. The percentage of c-fos immunopositive neurons that respond to FG-7142 during development in the rat [146]. Immature and mature rats were administered 20 mg/kg FG-7142, a pharmacological stressor, and the number of c-fos immunopositive neurons were quantified in the prefrontal cortex, nucleus accumbens, and the striatum.…”

Section: Clinical Implications Of Age and Sex Related Changes In Braimentioning

confidence: 99%

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Trajectories of brain development: point of vulnerability or window of opportunity?

Andersen

2003

Neuroscience & Biobehavioral Reviews

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Brain development is a remarkable process. Progenitor cells are born, differentiate, and migrate to their final locations. Axons and dendrites branch and form important synaptic connections that set the stage for encoding information potentially for the rest of life. In the mammalian brain, synapses and receptors within most regions are overproduced and eliminated by as much as 50% during two phases of life: immediately before birth and during the transitions from childhood, adolescence, to adulthood. This process results in different critical and sensitive periods of brain development. Since Hebb (1949) first postulated that the strengthening of synaptic elements occurs through functional validation, researchers have applied this approach to understanding the sculpting of the immature brain. In this manner, the brain becomes wired to match the needs of the environment. Extensions of this hypothesis posit that exposure to both positive and negative elements before adolescence can imprint on the final adult topography in a manner that differs from exposure to the same elements after adolescence. This review endeavors to provide an overview of key components of mammalian brain development while simultaneously providing a framework for how perturbations during these changes uniquely impinge on the final outcome. q

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Section: Age-dependent Differences In Pharmacological Sensitivity To mentioning

confidence: 93%

Section: Regional Selectivity Of Insultmentioning

confidence: 96%

Section: Age-dependent Differences In Pharmacological Sensitivity To mentioning

confidence: 99%

Section: Clinical Implications Of Age and Sex Related Changes In Braimentioning

confidence: 99%

See 2 more Smart Citations

Trajectories of brain development: point of vulnerability or window of opportunity?

Andersen

2003

Neuroscience & Biobehavioral Reviews

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1,325

1,006

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“…They likewise showed less widespread stress-induced FOS immunoreactivity than adult rats, exhibiting little activation in a number of brain regions such as the anterior olfactory nucleus, anterior cingulate cortex and medial and cortical amygdaloid nuclei that showed notable stress-induced increases in FOS immunoreactivity in adults [281]. In marked contrast, when examining the ontogeny of c-fos activation by the anxiogenic (and presumably stress-inducing) anxiogenic b-carboline FG-7142, Lyss and colleagues [341] concluded that immature rat brain showed more diffuse c-fos activation than adult brain, with PFC becoming preferentially activated by FG-7142 by P45.…”

Section: Stress and Adolescence In Nonhuman Animalsmentioning

confidence: 99%

The adolescent brain and age-related behavioral manifestations

Spear

2000

Neuroscience & Biobehavioral Reviews

4,734

110

4,301

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To successfully negotiate the developmental transition between youth and adulthood, adolescents must maneuver this often stressful period while acquiring skills necessary for independence. Certain behavioral features, including age-related increases in social behavior and risk-taking/novelty-seeking, are common among adolescents of diverse mammalian species and may aid in this process. Reduced positive incentive values from stimuli may lead adolescents to pursue new appetitive reinforcers through drug use and other risk-taking behaviors, with their relative insensitivity to drugs supporting comparatively greater per occasion use. Pubertal increases in gonadal hormones are a hallmark of adolescence, although there is little evidence for a simple association of these hormones with behavioral change during adolescence. Prominent developmental transformations are seen in prefrontal cortex and limbic brain regions of adolescents across a variety of species, alterations that include an apparent shift in the balance between mesocortical and mesolimbic dopamine systems. Developmental changes in these stressor-sensitive regions, which are critical for attributing incentive salience to drugs and other stimuli, likely contribute to the unique characteristics of adolescence. ᭧

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Dopamine receptor pruning in prefrontal cortex during the periadolescent period in rats

Andersen

Thompson

Rutstein

et al. 2000

Synapse

432

208

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Degree of neuronal activation following FG-7142 changes across regions during development

Cited by 36 publications

References 17 publications

Trajectories of brain development: point of vulnerability or window of opportunity?

Trajectories of brain development: point of vulnerability or window of opportunity?

The adolescent brain and age-related behavioral manifestations

Dopamine receptor pruning in prefrontal cortex during the periadolescent period in rats

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