Degree of tendon degeneration and stage of rotator cuff disease

Jo, Chris Hyunchul; Shin, Won Hyoung; Shin, Ji Sun; Kim, Ji Eun

doi:10.1007/s00167-016-4376-7

Cited by 32 publications

(41 citation statements)

References 40 publications

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“…Whereas factors and fate related to tear progression have not been clearly elucidated, most studies demonstrated that rotator cuff disease progressed from tendinopathy to partial‐thickness tear, and then eventually to fully‐thickness tear whether it was symptomatic or not . Progression of rotator cuff tear does not only mean the increase of the defect size, but also results in the deterioration of the tendon quality, retraction degree, degeneration of rotator cuff muscles, local osteoporosis of the proximal humerus, and osteoarthritis of the glenohumeral joint .…”

Section: Discussionmentioning

confidence: 99%

Intratendinous Injection of Autologous Adipose Tissue-Derived Mesenchymal Stem Cells for the Treatment of Rotator Cuff Disease: A First-In-Human Trial

et al. 2018

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Despite relatively good results of current symptomatic treatments for rotator cuff disease, there has been an unmet need for fundamental treatments to halt or reverse the progress of disease. The purpose of this study was to assess the safety and efficacy of intratendinous injection of autologous adipose tissue-derived mesenchymal stem cells (AD MSCs) in patients with rotator cuff disease. The first part of the study consists of three dose-escalation cohorts; the low- (1.0 × 10 cells), mid- (5.0 × 10 ), and high-dose (1.0 × 10 ) groups with three patients each for the evaluation of the safety and tolerability. The second part included nine patients receiving the high-dose for the evaluation of the exploratory efficacy. The primary outcomes were the safety and the shoulder pain and disability index (SPADI). Secondary outcomes included clinical, radiological, and arthroscopic evaluations. Twenty patients were enrolled in the study, and two patients were excluded. Intratendinous injection of AD MSCs was not associated with adverse events. It significantly decreased the SPADI scores by 80% and 77% in the mid- and high-dose groups, respectively. Shoulder pain was significantly alleviated by 71% in the high-dose group. Magnetic resonance imaging examination showed that volume of the bursal-side defect significantly decreased by 90% in the high-dose group. Arthroscopic examination demonstrated that volume of the articular- and bursal-side defects decreased by 83% and 90% in the mid- and high-dose groups, respectively. Intratendinous injection of autologous AD MSCs in patient with a partial-thickness rotator cuff tear did not cause adverse events, but improved shoulder function, and relieved pain through regeneration of rotator cuff tendon. Stem Cells 2018;36:1441-1450.

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Section: Discussionmentioning

confidence: 99%

Intratendinous Injection of Autologous Adipose Tissue-Derived Mesenchymal Stem Cells for the Treatment of Rotator Cuff Disease: A First-In-Human Trial

et al. 2018

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“…The unruptured rotator cuff samples were collected from the margins of the rotator cuff incision during humeral nail fixation. Our method has the advantage of being noninvasive—unlike the method of sampling from an intact rotator cuff as in the past studies . The disadvantage is that surgical methods are different between the Unruptured group (open surgery) and the Ruptured group (arthroscopic surgery).…”

Section: Discussionmentioning

confidence: 99%

“…Our method has the advantage of being noninvasiveunlike the method of sampling from an intact rotator cuff as in the past studies. 7,47,48 The disadvantage is that surgical methods are different between the Unruptured group (open surgery) and the Ruptured group (arthroscopic surgery). In addition, the degeneration score was high in the Unruptured group.…”

Section: Discussionmentioning

confidence: 99%

“…Rotator cuff degeneration in the animal model exhibits some characteristic pathological changes, including collagen fiber thinning and disarrangement, loss of cellularity, vascularity, and increased fibrocartilage in the rotator cuff. Notably, the same pathological changes were apparent in torn rotator cuffs in humans . The precise mechanism of the degeneration, however, remains unclear.…”

mentioning

confidence: 84%

“…Notably, the same pathological changes were apparent in torn rotator cuffs in humans. [5][6][7][8][9] The precise mechanism of the degeneration, however, remains unclear.…”

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confidence: 99%

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Association of Superoxide‐Induced Oxidative Stress With Rotator Cuff Tears in Human Patients

Yoshida

Itoigawa

Wada

et al. 2019

Journal Orthopaedic Research

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Rotator cuff degeneration is one of the factors contributing to rotator cuff tears. Oxidative stress is involved in tendon degeneration, and superoxide‐induced oxidative stress plays a pathological role in regulating the balance between oxidation and reduction. The role of oxidative stress in rotator cuff tears, however, is unclear. This study, therefore, aimed to investigate the contribution of superoxide‐induced oxidative stress to rotator cuff tears. Seventy patients were recruited and divided into two groups: patients with (Ruptured group) and those without (Unruptured group) a rotator cuff tear. Specimens from both groups were collected during surgery. Degeneration morphology was classified according to the degeneration score. Superoxide‐induced oxidative stress was assessed according to dihydroethidium (DHE) relative fluorescence intensity, capacity for antioxidation according to superoxide dismutase (SOD) activity, and the balance between oxidation and reduction based on the redox ratio. Data were compared between groups. Correlations between the degeneration score and the oxidative stress factors were calculated. Degeneration score and DHE relative fluorescence intensity were significantly higher in the Ruptured than the Unruptured group. The SOD activity was not significantly different between groups. Degeneration score was positively correlated with both DHE relative fluorescence intensity and SOD activity. Thus, superoxide‐induced oxidative stress and tendon degeneration were greater in rotator cuff tear tissues than in those with no tear, suggesting that oxidative imbalance may be involved in degenerative rotator cuff tears. Clinical Relevance: Understanding the mechanisms of superoxide‐induced oxidative stress may lead to targeted tissue therapy for degenerative rotator cuff tears. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:212–218, 2020

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Aging‐Related Rotator Cuff Tears: Molecular Mechanisms and Implications for Clinical Management

Wang,

Shen

et al. 2024

Advanced Biology

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Shoulder pain and disabilities are prevalent issues among the elderly population, with rotator cuff tear (RCT) being one of the leading causes. Although surgical treatment has shown some success, high postoperative retear rates remain a great challenge, particularly in elderly patients. Aging‐related degeneration of muscle, tendon, tendon‐to‐bone enthesis, and bone plays a critical role in the development and prognosis of RCT. Studies have demonstrated that aging worsens muscle atrophy and fatty infiltration, alters tendon structure and biomechanical properties, exacerbates enthesis degeneration, and reduces bone density. Although recent researches have contributed to understanding the pathophysiological mechanisms of aging‐related RCT, a comprehensive systematic review of this topic is still lacking. Therefore, this article aims to present a review of the pathophysiological changes and their clinical significance, as well as the molecular mechanisms underlying aging‐related RCT, with the goal of shedding light on new therapeutic approaches to reduce the occurrence of aging‐related RCT and improve postoperative prognosis in elderly patients.

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Degree of tendon degeneration and stage of rotator cuff disease

Abstract: Diagnostic, Level I.

Cited by 32 publications

References 40 publications

Intratendinous Injection of Autologous Adipose Tissue-Derived Mesenchymal Stem Cells for the Treatment of Rotator Cuff Disease: A First-In-Human Trial

Intratendinous Injection of Autologous Adipose Tissue-Derived Mesenchymal Stem Cells for the Treatment of Rotator Cuff Disease: A First-In-Human Trial

Association of Superoxide‐Induced Oxidative Stress With Rotator Cuff Tears in Human Patients

Aging‐Related Rotator Cuff Tears: Molecular Mechanisms and Implications for Clinical Management

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