Dehydroepiandrosterone and Dehydroepiandrosterone-Sulfate and Emotional Processing

Vale, Sónia do; Escera, Carles

doi:10.1016/bs.vh.2018.01.022

Cited by 6 publications

(3 citation statements)

References 94 publications

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“…Se ha documentado que niveles más altos de DHEA y DHEAS pueden reducir la actividad en las regiones del cerebro involucradas en la generación de emociones negativas. 26,27 En la población adulta mayor investigada, las personas deprimidas tuvieron en promedio valores medios de DHEAS significativamente más bajos que quienes no lo estaban, lo cual concuerda con lo reportado en la literatura.…”

Section: Discussionunclassified

Perfil de dehidroepiandrosterona sulfatada en adultos mayores costarricenses

Chacón

Marin-Baratta

2022

AMC

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Objetivo: Describir y relacionar los niveles de la hormona dehidroepiandrosterona sulfatadaen una muestra representativa nacional de adultos mayores con su salud, discapacidad,situación social, económica, antropométrica y de estado nutricional con el fin de aportarinformación sobre los valores de este biomarcador en la población general del país.Métodos: Con las respuestas a un cuestionario autorreportado de una muestra deadultos mayores, se midió el estado de salud físico y mental, valores de ingesta calóricay niveles de dehidroepiandrosterona sulfatada en suero de los entrevistados.Resultados: Los valores promedio de dehidroepiandrosterona sulfatada muestran unadisminución progresiva según edad, en hombres con un promedio de 70.9 ± 46.6 μg/dl y en mujeres de 38.9 ± 29.4 μg/dl. Valores más bajos se obtienen en personas que seautorreportan como de buena situación económica o con mejor nivel educativo, conhipertensión, hipercolesterolemia, diabetes, con bajo peso u obesidad y en quienesconsumen menos de 1500 o más de 3000 calorías por día.Conclusiones: Las diferencias por sexo y edad observadas, así como en el comportamientode la distribución, son las esperadas y corresponden a lo descrito en la literatura para estahormona. Eventos adversos en salud, como reporte de padecimiento de enfermedadescrónicas, valores extremos del índice de masa corporal, sedentarismo, discapacidad ydepresión están asociados a niveles medios o bajos de DHEAS.

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Section: Discussionunclassified

Perfil de dehidroepiandrosterona sulfatada en adultos mayores costarricenses

Chacón

Marin-Baratta

2022

AMC

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“…DHEA and DHEA-S (collectively referred here to DHEA(S)) are also associated with better performance under stressful condition [ 34 ]. Besides, accumulating evidence suggests that DHEA(S) is associated with neural processing of emotional stimuli [ 35 ]. For instance, exogenous DHEA administration, relative to placebo, reduced the activity of amygdala and hippocampus, and enhanced the activity of medial prefrontal cortex (or more precisely, the rostral ACC) during a task requiring implicit emotional processing and regulation [ 36 ].…”

Section: Introductionmentioning

confidence: 99%

Inter-individual differences in pain anticipation and pain perception in migraine: Neural correlates of migraine frequency and cortisol-to-dehydroepiandrosterone sulfate (DHEA-S) ratio

et al. 2021

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Previous studies targeting inter-individual differences in pain processing in migraine mainly focused on the perception of pain. Our main aim was to disentangle pain anticipation and perception using a classical fear conditioning task, and investigate how migraine frequency and pre-scan cortisol-to-dehydroepiandrosterone sulfate (DHEA-S) ratio as an index of neurobiological stress response would relate to neural activation in these two phases. Functional Magnetic Resonance Imaging (fMRI) data of 23 participants (18 females; mean age: 27.61± 5.36) with episodic migraine without aura were analysed. We found that migraine frequency was significantly associated with pain anticipation in brain regions comprising the midcingulate and caudate, whereas pre-scan cortisol-to DHEA-S ratio was related to pain perception in the pre-supplementary motor area (pre-SMA). Both results suggest exaggerated preparatory responses to pain or more general to stressors, which may contribute to the allostatic load caused by stressors and migraine attacks on the brain.

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“…Thus, higher DHEA-to-cortisol and DHEAS-to-DHEA ratios are hypothesized to be involved in negative stimuli processing, preventing the interference of negative stimuli in cognitive tasks. DHEA-S may play important roles in cortical development and plasticity, protection against negative affect and depression, and might even enhance attention and overall working memory ( 14 ). Alterations in DHEA activity seem to be trait rather than state phenomena and are predictive of future depressive episodes ( 15 – 17 ).…”

Section: Introductionmentioning

confidence: 99%

Chronic Depression Alters Mothers’ DHEA and DEHA-to-Cortisol Ratio: Implications for Maternal Behavior and Child Outcomes

2020

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Maternal depression is a major public health problem that typically occurs in the period surrounding childbirth. The neurobiological mechanisms underlying maternal depression have been the focus of increasing research and studies pointed to the crucial role of the HPA axis in this disorder. However, most studies focused on cortisol expression and regulation while recent attention has shifted to include the sulfate steroids DHEA and DHEA-S. A community cohort of 1,983 women with no comorbid risk was recruited at birth and depression was assessed periodically across the first postpartum year. At 6 years, 156 families were re-visited: 46 mothers were defined as chronically-depressed and 103 controls reported no depression from birth to six years. Mothers and children were diagnosed by structured psychiatric interviews and mother-child interactions were observed. Maternal diurnal cortisol (CT) and dehydroepiandrosterone (DHEA) were assessed. Depressed mothers had lower levels of DHEA (AUCg), flattened DHEA diurnal variability (AUCi), and smaller DHEA-to-CT Ratio. Regression analysis demonstrated that maternal sensitivity during mother-child interaction was independently predicted by maternal depression, DHEA levels, child CT, and child social withdrawal. Results underscore the need for multi-level understanding of the dynamic interplay between maternal psychopathology, mother-child relationship, and pituitary-adrenal-cortex-to-medulla balance in studying the cross generational transfer of psychiatric vulnerability from depressed mothers to their children.

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Dehydroepiandrosterone and Dehydroepiandrosterone-Sulfate and Emotional Processing

Cited by 6 publications

References 94 publications

Perfil de dehidroepiandrosterona sulfatada en adultos mayores costarricenses

Perfil de dehidroepiandrosterona sulfatada en adultos mayores costarricenses

Inter-individual differences in pain anticipation and pain perception in migraine: Neural correlates of migraine frequency and cortisol-to-dehydroepiandrosterone sulfate (DHEA-S) ratio

Chronic Depression Alters Mothers’ DHEA and DEHA-to-Cortisol Ratio: Implications for Maternal Behavior and Child Outcomes

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