Dehydroepiandrosterone decreases while cortisol increases in vitro growth and viability of Entamoeba histolytica

Steroid hormones alter AMP hydrolysis in intact trophozoites of Trichomonas vaginalis

“…(Ayi et al 2002). Carrero et al (2006) presented evidence on the direct in vitro effect of DHEA on growth and viability of Entamoeba histolytica trophozoites. In vivo evidence on the anti-malarial effect of DHEA came from the inverse correlation found in young women from Kenya, between the levels of bloodcirculating DHEA and the parasitemia (Leenstra et al 2003).…”

Endocrine Immune Interactions in the Host-Parasite Relationship: Steroid Hormones as Immune Regulators in Parasite Infections

“…During infection neutrophils play an important role in both diseases. For example, the alpha-defensins secreted by neutrophils in vitro have anti-giardial properties [133] and neutrophildepleted mice have more severe amoebic liver abscess (ALA) and intestinal amoebiasis [134]. Macrophages produced NO is involved in protection of invasive amoebiasis [135].…”

“…In vitro exposure to DHEA and cortisol increase E. histolytica trophozoite proliferation and DNA synthesis. DHEA also induces a progressive loss of adherence capacity, which is crucial during intestinal infection [134] (Figure 1). In contrast, during intestinal infection treatment with testosterone (T 4) stimulated trophozoites migration from intestine to liver and increased ALA infections [141].…”

Neuroimmunoendocrine Interactions in Murine Cysticercosis: From the Lab Bench Work to Its Possible Applications in Controlling Porcine Cysticercosis and Human Neurocysticercosis

“…In vitro, DHEA has a strong cysticidal effect, being dose-dependent in physiological and pharmacological conditions. In vivo assays showed that DHEA reduce the viability of cysticerci in both male and female mice (Carrero et al, 2006;Carrero et al, 2010).…”

“…Cryptosporidium parvum (Rasmussen & Healey, 1992) Plasmodium falciparum (Kurtis et al, 2001) Entamoeba histolytica (Carrero et al, 2006) Schistosoma mansoni (Fallon et al, 1998) Trypanosoma cruzi (dos Santos et al, 2005) 16 -bromoepiandrosterone (EpiBr or HE2000)…”