Dehydroepiandrosterone (DHEA), DHEA Sulfate, and Aging: Contribution of the DHEAge Study to a Sociobiomedical Issue

Baulieu, Étienne-Émile; Thomas, Guy; Legrain, S.; Lahlou, Najiba; Roger, M; Debuire, Brigitte; Faucounau, V.; Girard, L.; Hervy, Marie-Pierre; Latour, F.; LEAUD, M. BESSON; Mokrane, Amina; Pitti-Ferrandi, Hélène; Trivalle, C.; Lacharriére, Olivier de; Nouveau, Stéphanie; Rakoto-Arison, Brigitte; Souberbielle, Jean‐Claude; J, Raison; Bouc, Yves Le; Raynaud, A; Girerd, Xavier; Forette, Françoise

doi:10.1097/00006254-200011000-00018

Cited by 40 publications

(67 citation statements)

References 11 publications

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“…This is consistent with the present finding of an increase in IFN-γ plasma levels between middle-age and old-age in mouse lemurs. DHEA-S is accepted as a good biomarker of aging, as its levels progressively decrease with advancing age in various species, including humans (Baulieu et al, 2000;Tannenbaum et al, 2004). Such a decrease with age has previously been demonstrated in mouse lemurs , and it is confirmed by the present results.…”

Section: Discussionsupporting

confidence: 90%

PLASMA LEVELS OF INTERFERON-γ CORRELATE WITH AGE-RELATED DISTURBANCES OF CIRCADIAN RHYTHMS AND SURVIVAL IN a NON-HUMAN PRIMATE

Cayetanot¹,

Nygård²,

Perret³

et al. 2009

Chronobiology International

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Aging can be associated with changes in circadian rhythms and reduction in adaptive immune responses accompanied by expansion of memory T cells and elevated levels of pro-inflammatory cytokines. Recent findings suggest the cytokine interferon-gamma (IFN-gamma) can affect the function of the hypothalamic suprachiasmatic nucleus (SCN), the master mammalian circadian pacemaker, both in vitro and in vivo. We studied the correlation of plasma levels of IFN-gamma and changes in circadian rhythms in a non-human primate species, the nocturnal mouse lemur (Microcebus murinus). Plasma IFN-gamma and dehydroepiandrosterone sulfate (DHEA-S), a known biomarker of aging, were determined in middle- to old-age animals by immunoenzymoassay. Daily rhythms of locomotor activity and body temperature as well as survival time of the lemurs were recorded. With aging, mean levels of DHEA-S decreased whereas IFN-gamma increased. Aged animals showed biological rhythm alterations characterized by a high percentage of diurnal activity, anticipation of the activity onset relative to lights-off, short free-running period, and delayed occurrence of minimal body temperature. The magnitude of these disturbances was correlated with the plasma level of IFN-gamma but not DHEA-S. Most remarkably, in contrast to DHEA-S, increased levels of IFN-gamma correlated with duration of the lifetime of the lemurs. These results show the degree of circadian rhythm alterations in an individual is correlated with plasma IFN-gamma level during aging, and that plasma IFN-gamma level may predict survival, at least in this non-human primate.

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Section: Discussionsupporting

confidence: 90%

PLASMA LEVELS OF INTERFERON-γ CORRELATE WITH AGE-RELATED DISTURBANCES OF CIRCADIAN RHYTHMS AND SURVIVAL IN a NON-HUMAN PRIMATE

Cayetanot¹,

Nygård²,

Perret³

et al. 2009

Chronobiology International

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“…On the other hand, much attention has been given to the benefits of DHEA administered to postmenopausal women, especially on the bone, skin, muscle, vaginum, adipose tissue, insulin resistance and well being after oral and percutaneous administration [4,[21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Metabolism of DHEA in postmenopausal women following percutaneous administration

Labrie

Bélanger

et al. 2007

The Journal of Steroid Biochemistry and Molecular Biology

115

112

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“…Old age is a common factor for PH incidence and low endogenous blood DHEA(S) levels in humans [28]. Therefore old age may play a particular role in the treatment of hypoxic PH by DHEA, and it was not obvious that results obtained in young adults could be transposed to old adults (especially from rats to mice).…”

Section: Discussionmentioning

confidence: 99%

“…However DHEA induced an unexpected decrease of survival after the age of 24 months compared to the control mice (p = 0.0025), and this may not at all apply to humans. In humans it was shown that DHEA may be safely administered to older persons at the daily oral dose of 50 mg (~1 mg/kg/day) for one year [28]. In comparison, the doses used to treat PH in animals are larger (~9 mg/kg/day by Hampl V et al .…”

Section: Discussionmentioning

confidence: 99%

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Hypoxia and dehydroepiandrosterone in old age: a mouse survival study

2006

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Background: Survival remains an issue in pulmonary hypertension, a chronic disorder that often affects aged human adults. In young adult mice and rats, chronic 50% hypoxia (11% FIO2 or 0.5 atm) induces pulmonary hypertension without threatening life. In this framework, oral dehydroepiandrosterone was recently shown to prevent and reverse pulmonary hypertension in rats within a few weeks. To evaluate dehydroepiandrosterone therapy more globally, in the long term and in old age, we investigated whether hypoxia decreases lifespan and whether dehydroepiandrosterone improves survival under hypoxia.

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Dehydroepiandrosterone (DHEA), DHEA Sulfate, and Aging: Contribution of the DHEAge Study to a Sociobiomedical Issue

Cited by 40 publications

References 11 publications

PLASMA LEVELS OF INTERFERON-γ CORRELATE WITH AGE-RELATED DISTURBANCES OF CIRCADIAN RHYTHMS AND SURVIVAL IN a NON-HUMAN PRIMATE

PLASMA LEVELS OF INTERFERON-γ CORRELATE WITH AGE-RELATED DISTURBANCES OF CIRCADIAN RHYTHMS AND SURVIVAL IN a NON-HUMAN PRIMATE

Metabolism of DHEA in postmenopausal women following percutaneous administration

Hypoxia and dehydroepiandrosterone in old age: a mouse survival study

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