Dehydroepiandrosterone Replacement in Women With Adrenal Insufficiency

Arlt, Wiebke; Callies, Frank; Vlijmen, Jan Christoph van; Koehler, Ines; Reincke, Martín; Bidlingmaier, Martin; Huebler, Doris; Oettel, M; Ernst, Michael E.; Schulte, Heinrich M.; Allolio, Bruno

doi:10.1097/00006254-200003000-00022

Cited by 91 publications

(135 citation statements)

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“…Effects of tibolone and DHEA on libido were found to be similar, but statistically better than that of CEE (Table 1). This finding is supported by Arlt [4] who reported that DHEA significantly increases the frequency of sexual desire. No patient in tibolone group developed genital symptoms, which proves its better effect on genitourinary symptoms as compared with other two drugs, and supported by Davis [3].…”

Section: Discussionsupporting

confidence: 57%

A Comparative Study of CEE, Tibolone, and DHEA as Hormone Replacement Therapy for Surgical Menopause

Gupta

Mittal

Khuteta

et al. 2012

J Obstet Gynecol India

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Objective(s) The objective of this study was to compare the efficacy and safety of CEE, tibolone, and DHEA for prevention of menopausal symptoms. Method(s) One hundred patients with surgical menopause were included in this study: 25 of whom were not treated with any HRT, 25 were treated with 0.625 mg of CEE, 25 were treated with 2.5 mg of tibolone, and 25 were treated with 25 mg of DHEA for 1 year, and the results were statistically analyzed regarding drug efficacy and side effects at follow-up periods of 1, 6 and 12 months. Result(s) Frequency of menopausal symptoms was significantly less in cases received with CEE, tibolone, DHEA with p values 0.001, 0.004 and 0.004, respectively. Percentage gain in BMD was 2.8 % with CEE at lumbar spine, which was greater than that caused by DHEA and tibolone, but this difference was not statistically significant. CEE caused side effects like headache (40 %) and nausea (28 %). Conclusion(s) CEE, Tibolone, and DHEA are very effective in alleviating climacteric symptoms. CEE has beneficial effects on lipid and bone and is a low-cost drug but frequently causes side effects. Tibolone offers beneficial androgenic effects on mood and libido with fewer side effects but is a costly drug. DHEA shows positive effects on psychological symptoms. However, its cost and androgenic side effects limit its use as long-term HRT.

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Section: Discussionsupporting

confidence: 57%

A Comparative Study of CEE, Tibolone, and DHEA as Hormone Replacement Therapy for Surgical Menopause

Gupta

Mittal

Khuteta

et al. 2012

J Obstet Gynecol India

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“…A clear example of DHEA-S deficiency is subjects with primary adrenal insufficiency, who maintain a reduced general health perception even with optimal mineralocorticoid and glucocorticoid therapy (Lovas et al, 2002). Recent studies have shown that oral DHEA improves sexual satisfaction, mood and energy in women with adrenal insufficiency who make no DHEA-S and little testosterone (Arlt et al, 1999).…”

Section: Clinical Impact Of Dhea-s Deficiencymentioning

confidence: 99%

Adrenarche – physiology, biochemistry and human disease

Auchus¹,

Rainey

2003

Clinical Endocrinology

259

148

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SummaryAdrenarche refers to the onset of dehydroepiandrosterone (DHEA) and DHEA-sulphate (DHEA-S) production from the adrenal zona reticularis that can be detected at around 6 years of age. The phenotypic result of adrenarche is pubarche or the development of axillary and pubic hair that occurs in both girls and boys at about age 8. The phenomenon of adrenarche is unique to human beings and to some Old World primates, and a reversal of adrenarche appears to occur in the ageing process. Premature and exaggerated adrenarche can be indicative of future onset of adult diseases, thus increasing the clinical relevance of adrenarche. The physiological triggers of adrenarche and the role(s) of DHEA-S remain speculative. However, the biochemical pathways that define adrenarche have been characterized in detail, and the appearance of key enzymes and cofactors in the adrenal zona reticularis track with the progression of adrenarche. This article reviews the clinical manifestations of adrenarche, the biochemistry of the enzymes involved in DHEA-S production, and the cell biology of the adrenal zona reticularis.Glucocorticoids and mineralocorticoids secreted by the adrenal glands are essential for the maintenance of vascular tone and carbohydrate metabolism or of blood volume and sodium balance, respectively. The testes and ovaries, by contrast, generate the sex steroids that are required for gametogenesis, secondary sexual characteristics and reproduction. However, the adrenal glands of adult human beings secrete generous quantities of the C 19 steroids dehydroepiandrosterone (DHEA) and DHEA-sulphate

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“…There is little clinical use of DHEA with the exception in the case of pathologic adrenal failure. DHEA replacement is associated with improvements in these patients (Arlt et al, 1999).…”

Section: Dehydroepiandrosteronementioning

confidence: 98%

Hormonal regulation of longevity in mammals

Brown‐Borg

2007

Ageing Research Reviews

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Multiple biological and environmental factors impact the life span of an organism. The endocrine system is a highly integrated physiological system in mammals that regulates metabolism, growth, reproduction, and response to stress, among other functions. As such, this pervasive entity has a major influence on aging and longevity. The growth hormone, insulin-like growth factor-1 and insulin pathways have been at the forefront of hormonal control of aging research in the last few years. Other hormones, including those from the thyroid and reproductive system have also been studied in terms of life span regulation. The relevance of these hormones to human longevity remains to be established, however the evidence from other species including yeast, nematodes, and flies suggest that evolutionarily well-conserved mechanisms are at play and the endocrine system is a key determinant.

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Dehydroepiandrosterone Replacement in Women With Adrenal Insufficiency

Cited by 91 publications

References 0 publications

A Comparative Study of CEE, Tibolone, and DHEA as Hormone Replacement Therapy for Surgical Menopause

A Comparative Study of CEE, Tibolone, and DHEA as Hormone Replacement Therapy for Surgical Menopause

Adrenarche – physiology, biochemistry and human disease

Hormonal regulation of longevity in mammals

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