Dehydroepiandrosterone Sulphate (DS), Dehydroepiandrosterone (D) and “Free” Dehydroepiandrosterone (FD) in the Plasma of Patients with Thyroid Diseases

Földes, J; Fehér, T; Fehér, Katalin G.; Kollin, E; Bodrogi, L.

doi:10.1055/s-2007-1018809

Cited by 11 publications

(4 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regarding the basal DHEA levels in the hyper‐ and euthyroid states, our study was consistent with the reports of Foldes et al . (1983) and Tagawa et al .…”

Section: Discussionsupporting

confidence: 93%

Dehydroepiandrosterone sulphate is increased and dehydroepiandrosterone‐response to corticotrophin‐releasing hormone is decreased in the hyperthyroid state compared with the euthyroid state

Yamakita

Murai

Kokubo

et al. 2001

Clinical Endocrinology

View full text Add to dashboard Cite

The balance of the conversion between DHEA-S and DHEA in the hyperthyroid state favoured DHEA-S. Similar to cortisol, the DHEA response in the CRH test in hyperthyroidism seemed to be insufficiently compensated for by increased ACTH, although the DHEA response to low-dose ACTH was similar in the hyperthyroid and euthyroid states. Increased DHEA-S might play some role in the pathological states in many organs in hyperthyroidism.

show abstract

“…Regarding the basal DHEA levels in the hyper‐ and euthyroid states, our study was consistent with the reports of Foldes et al . (1983) and Tagawa et al .…”

Section: Discussionsupporting

confidence: 93%

Dehydroepiandrosterone sulphate is increased and dehydroepiandrosterone‐response to corticotrophin‐releasing hormone is decreased in the hyperthyroid state compared with the euthyroid state

Yamakita

Murai

Kokubo

et al. 2001

Clinical Endocrinology

View full text Add to dashboard Cite

show abstract

“…The thyroid func tion is probably also important for the metabolism of DHAS during pregnancy, as illustrated by the significant associations between DHAS and total and fT*. Foldes et al [26] have previously reported that DHAS levels in crease and DHA/DHAS ratios decrease with increasing thyroid activity in nonpregnant women. A modulating action of thyroid hormones on adrenocortical sulfotransferase activity and/or the balance between hepatic sulfa tase and sulfotransferase may also contribute to the changes in DHAS observed in the present study.…”

Section: Discussionmentioning

confidence: 95%

Serum Levels of Androgens and Estrogens and ‘Steroid-Sensitive’ Liver Proteins in Early Human Pregnancy: Influence on the Gender of the Offspring

Sparre

Carlström²,

Schoultz³

et al. 1995

Gynecol Obstet Invest

View full text Add to dashboard Cite

Serum androgens, estrogens, ‘steroid-sensitive proteins’, thyroid components, and albumin were measured twice within a 4- to 5-week interval in 44 cases of early normal pregnancy (gestational weeks 8–18). Positive correlations were found in the total material between dehydroepiandrosterone sulfate (DHAS) and testosterone (T), unconjugated and total estrone, albumin, tetraiodothyronine, and calculated free tetraiodothyronine concentrations and within 2-week intervals between DHAS and T, estradiol-17β, and unconjugated and total estrone, and between T and estradiol-17β and unconjugated estrone. Positive correlations were also found between the rates of change in DHAS of albumin. No significant association was found between ‘steroid-sensitive proteins’ and androgens or androgen/estrogen ratios. Women giving birth to girls had significantly higher serum levels of pregnancy-associated α₂-macroglobulin, thyroxine-binding globulin, and ceruloplasmin and lower ratios between T and sex hormone binding globulin than women giving birth to boys. The important role of placental aromatization in the metabolism of maternal androgens is well known. Albumin binding and thyroid status may also affect the metabolism of DHAS during pregnancy. The androgen/estrogen balance may be of little importance for the regulation of ‘steroid-sensitive’ proteins during early pregnancy. The mechanism behind the higher serum levels of pregnancy-associated α₂-macroglobulin, thyroxine-binding globulin, and ceruloplasmin in women giving birth to girls remains to be elucidated.

show abstract

“…17 The study findings also in accordance with the research findings conducted by J Foldes et al who studied serum DHEA and DHEAS levels in female subjects aged between 25 and 45 years. 28 A highly significant decrease of DHEA as well as DHEAS level in patients with hypothyroidism was reported by their study. Our finding was also in agreement with another study conducted by Noriko Tangawa et al who evaluated DHEA and DHEAS along with other sterols in 31 untreated patients with hypothyroidism.…”

Section: Discussionmentioning

confidence: 71%

Alteration of serum dehydroepiandrosterone and its sulfated derivative in hypothyroidism

Mukherjee¹,

Samanta²,

Upadhyay³

2020

IJCBR

View full text Add to dashboard Cite

Introduction: Dysfunction of thyroid gland are among the most common disease of endocrine glands which affect a considerable portion of the population. Thyroid abnormalities are accompanied by changes in various intermediary metabolism which results in body weight alteration, insulin resistance, lipid profile and various biochemical parameters. Changes in dehydroepiandrosterone (DHEA) and its sulfated metabolite (Dehydroepiandrosterone sulfate) have been reported in patients with thyroid hypofunction but the evidence is controversial and not yet established. The present study planned to explore the association between thyroid function with DHEA and DHEAS levels in hypothyroid patients. Materials and Methods: An observational case control study was conducted in OPD patients of Rajshree Medical College of Rohilkhand region. RMRI, Bareilly.70 newly diagnosed hypothyroid patients were selected and all the biochemical parameters (plasma glucose, thyroid profile, DHEA and DHEAS) were compared with 70 age and sex matched healthy euthyroid controls. Statistical analysis was done using SPSS 22.0. version. Results: We found that serum DHEA and DHEAS levels were significantly reduced in hypothyroid patients as compared to control (p<0.0001). Significant negative correlation was observed between DHEA and its sulfated form with TSH and positive association with thyroid hormones (T3, T4, fT3, fT4). Conclusion:The present study demonstrated that hypothyroidism is associated with significantly low levels of DHEA and DHEAS concentration. Alteration of these sterols in hypothyroidism clearly indicates that thyroid hormone may stimulate the synthesis of these androgen precursors, though more elaborate study with increased sample size may provide more insights.

show abstract

Dehydroepiandrosterone Sulphate (DS), Dehydroepiandrosterone (D) and “Free” Dehydroepiandrosterone (FD) in the Plasma of Patients with Thyroid Diseases

Cited by 11 publications

References 4 publications

Dehydroepiandrosterone sulphate is increased and dehydroepiandrosterone‐response to corticotrophin‐releasing hormone is decreased in the hyperthyroid state compared with the euthyroid state

Dehydroepiandrosterone sulphate is increased and dehydroepiandrosterone‐response to corticotrophin‐releasing hormone is decreased in the hyperthyroid state compared with the euthyroid state

Serum Levels of Androgens and Estrogens and ‘Steroid-Sensitive’ Liver Proteins in Early Human Pregnancy: Influence on the Gender of the Offspring

Alteration of serum dehydroepiandrosterone and its sulfated derivative in hypothyroidism

Contact Info

Product

Resources

About