Dehydroepiandrosterone sulphate in Alzheimer disease

Späth‐Schwalbe, E.; Dodt, Christoph; Dittmann, J.; Schüttler, R.; Fehm, Horst L.

doi:10.1016/0140-6736(90)91298-o

Cited by 34 publications

(16 citation statements)

References 3 publications

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“…Five subsequent reports [8][9][10][11][12] have not supported these findings, while one report by Nasman et al [6] studying 45 AD patients, the largest sample size so far, has demonstrated a lower concentration of serum DHEA-S not only in patients with AD but also in patients with multi-infarct dementia (MID). Such a discrepancy may be attributed to slight differences in the sample size, age and gender distribution.…”

Section: Statisticsmentioning

confidence: 74%

“…However, the exact concentrations of serum in DHEA-S must still be regarded as controversial, since five other studies found no difference in serum DHEA-S level between AD patients and controls [8][9][10][11][12]. All of the previous studies have focused only on circulating DHEA-S levels and have not yet examined another important index, namely serum DHEA levels in AD.…”

Section: Dehydroepiandrosteronementioning

confidence: 99%

See 1 more Smart Citation

Serum Dehydroepiandrosterone (DHEA) and DHEA-Sulfate (DHEA-S) in Alzheimer's Disease and in Cerebrovascular Dementia.

et al. 1996

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Section: Statisticsmentioning

confidence: 74%

Section: Dehydroepiandrosteronementioning

confidence: 99%

Serum Dehydroepiandrosterone (DHEA) and DHEA-Sulfate (DHEA-S) in Alzheimer's Disease and in Cerebrovascular Dementia.

et al. 1996

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“…The decline of DHEAS with age has led to considering the intriguing possibility that its serum levels are related to the development of age-associated ''normal'' changes, as well as diseases such as cancer, atherosclerosis, or Alzheimer disease (14)(15)(16)(17)(18)(19)(20)(21)(22). Results to date have not been conclusive.…”

mentioning

confidence: 90%

Relationships of dehydroepiandrosterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality: A French community-based study

Berr

Lafont

Debuire

et al. 1996

Proc. Natl. Acad. Sci. U.S.A.

258

128

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In human beings of both sexes, dehydroepiandrosterone sulfate (DHEAS) circulating in blood is mostly an adrenally secreted steroid whose serum concentration (in the micromolar range and 30-50% higher in men than in women) decreases with age, toward Ϸ20-10% of its value in young adults during the 8th and 9th decades. The mechanism of action of DHEA and DHEAS is poorly known and may include partial transformation into sex steroids, increase of bioavailable insulin-like growth factor I, and effects on neurotransmitter receptors. Whether there is a cause-to-effect relationship between the decreasing levels of DHEAS with age and physiological and pathological manifestations of aging is still undecided, but this is of obvious theoretical and practical interest in view of the easy restoration by DHEA administration. Here we report on 622 subjects over 65 years of age, studied for the 4 years since DHEAS baseline values had been obtained, in the frame of the PAQUID program, analyzing the functional, psychological, and mental status of a communitybased population in the south-west of France. We confirm the continuing decrease of DHEAS serum concentration with age, more in men than in women, even if men retain higher levels. Significantly lower values of baseline DHEAS were recorded in women in cases of functional limitation (Instrumental Activities of Daily Living), confinement, dyspnea, depressive symptomatology, poor subjective perception of health and life satisfaction, and usage of various medications. In men, there was a trend for the same correlations, even though not statistically significant in most categories. No differences in DHEAS levels were found in cases of incident dementia in the following 4 years. In men (but not in women), lower DHEAS was significantly associated with increased short-term mortality at 2 and 4 years after baseline measurement. These results, statistically established by taking into account corrections for age, sex, and health indicators, suggest the need for further careful trials of the administration of replacement doses of DHEA in aging humans. Indeed, the first noted results of such ''treatment'' are consistent with correlations observed here between functional and psychological status and endogenous steroid serum concentrations.

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“…We cannot exclude the possibility that the decline of endogenous DHEA and DHEA-S concentrations may be an important factor in more poorly functioning individuals or in individuals with dementia. Although case-control studies [7][8][9][10] comparing DHEA-S concentrations in individuals with or without dementia have yielded mixed results, the possibility that DHEA supplementation may prove beneficial in AD or other forms of dementia may merit further consideration.…”

Section: Commentmentioning

confidence: 99%

“…One study 7 reported reduced circulating concentrations of DHEA-S in patients with AD, but this finding has not been replicated. [8][9][10] Epidemiological studies [11][12][13][14] of the association between DHEA-S concentrations and cognitive status in elderly subjects without dementia have yielded largely negative results. Barrett-Connor and Edelstein 11 found that baseline DHEA-S concentrations did not predict 16-year follow-up measures of mental status, verbal or visual memory, category fluency, or visuomotor processing in men or women.…”

Section: Ehydroepiandrosteronementioning

confidence: 99%

The Relationship Between Longitudinal Declines in Dehydroepiandrosterone Sulfate Concentrations and Cognitive Performance in Older Men

et al. 2000

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Dehydroepiandrosterone sulphate in Alzheimer disease

Cited by 34 publications

References 3 publications

Serum Dehydroepiandrosterone (DHEA) and DHEA-Sulfate (DHEA-S) in Alzheimer's Disease and in Cerebrovascular Dementia.

Serum Dehydroepiandrosterone (DHEA) and DHEA-Sulfate (DHEA-S) in Alzheimer's Disease and in Cerebrovascular Dementia.

Relationships of dehydroepiandrosterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality: A French community-based study

The Relationship Between Longitudinal Declines in Dehydroepiandrosterone Sulfate Concentrations and Cognitive Performance in Older Men

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