2004
DOI: 10.1271/bbb.68.448
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Dehydrotrametenonic Acid and Dehydroeburiconic Acid fromPoria cocosand Their Inhibitory Effects on Eukaryotic DNA Polymerase α and β

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Cited by 36 publications
(57 citation statements)
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“…The chemical structures of compounds 1-9 are shown in Fig. 1 18) This was fully supported by 13 C-NMR data of 8 (Table 1), which showed the signals of C-7 (d 120.9), C-8 (d 142.8) and C-9 (d 144.4), C-11 (d 118.0) revealing the presence 18) of D. 7,9,11) In addition, there was one carboxyl resonance at d 178.6 (C-21), one ketone carbon at d 215.5 (C-3), and an oxymethine resonance at d 75.6 (C-16) in the 13 C-NMR of 8. On the basis of comparison of the NMR spectral data with those of polyporenic acid C (4), 10) 8 could be assigned as a close derivative of polyporenic acid C. A significant difference in the 1 H-NMR spectrum showed that H-29 appeared at d 3.59, 4.17 (each 1H, d, Jϭ10.5 Hz), rather than at d 1.14, which correlated with a hydroxymethyl carbon at d 66.9 in the HMQC spectrum.…”
Section: Resultssupporting
confidence: 52%
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“…The chemical structures of compounds 1-9 are shown in Fig. 1 18) This was fully supported by 13 C-NMR data of 8 (Table 1), which showed the signals of C-7 (d 120.9), C-8 (d 142.8) and C-9 (d 144.4), C-11 (d 118.0) revealing the presence 18) of D. 7,9,11) In addition, there was one carboxyl resonance at d 178.6 (C-21), one ketone carbon at d 215.5 (C-3), and an oxymethine resonance at d 75.6 (C-16) in the 13 C-NMR of 8. On the basis of comparison of the NMR spectral data with those of polyporenic acid C (4), 10) 8 could be assigned as a close derivative of polyporenic acid C. A significant difference in the 1 H-NMR spectrum showed that H-29 appeared at d 3.59, 4.17 (each 1H, d, Jϭ10.5 Hz), rather than at d 1.14, which correlated with a hydroxymethyl carbon at d 66.9 in the HMQC spectrum.…”
Section: Resultssupporting
confidence: 52%
“…8-10) Likewise, lanostane-type triterpenes from alcoholic extracts were shown to possess certain anti-cancer properties, including inhibition of DNA polymerases, 4,11) inhibition of tumor cell growth induced by TPA (12-O-tetradecanoylphorbol-13-acetate), 2,12,13) and inhibition of DNA topoisomerase II.…”
Section: Notesmentioning
confidence: 99%
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“…The main chemical constituents of P. cocos are polysaccharides, triterpenoids, egosterol and proteins (Tai, Akahori, & Shingu, 1992;Tai, Shingu, Kikuchi, Tezuka, & Akahori, 1995a;Tai, Shingu, Kikuchi, Tezuka, & Akahori, 1995b;Wang & Wan, 1998;Yang & Bao, 2005), in which triterpenoids are found to possess interesting pharmacological actions such as cytotoxic and anti-oxidant (Zhou et al, 2008), anti-cancer (Gapter, Wang, Glinski, & Ng, 2005), anti-inflammatory (Yasukawa et al, 1998), inhibition of free radical-induced lysis of red blood cells (Sekiya, Goto, Shimada, & Terasawa, 1998) and inhibition of calf DNA polymerase a and rat DNA polymerase b (Akihisa et al, 2004;Kaminaga et al, 1996). Up to now, more than 80 triterpenoid compounds were isolated and identified from P. cocos with the above-mentioned bioactivities.…”
Section: Introductionmentioning
confidence: 99%