Del CLSI al EUCAST, una transición necesaria en los laboratorios españoles

Larrosa, Nieves; Benito, Natividad; Canut, Andrés; Cercenado, Emilia; Fernández-Cuenca, Felipe; Guinea, Jesús; López-Navas, Antonio; Moreno, Miguel A.; Oliver, Antonio; Martı́nez-Martı́nez, Luis

doi:10.1016/j.eimc.2018.09.014

Cited by 12 publications

(3 citation statements)

References 21 publications

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“…We believe that with this approach, the implementation of EUCAST breakpoints will be easier, increasing the quality of data and their microbiological interpretation. 44,45 Finally, it will benefit epidemiological surveillances as well as the clinical use of antimicrobials aligned with the stewardship programs.…”

Section: Discussionmentioning

confidence: 99%

Recommendations of the Spanish Antibiogram Committee (COESANT) for selecting antimicrobial agents and concentrations for in vitro susceptibility studies using automated systems

Oliver

Alós

Benito

et al. 2020

Enfermedades Infecciosas y Microbiología Clínica

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Palabras clave: Antibiograma Sistemas automáticos de detección de sensibilidad Concentraciones mínimas antimicrobianas CMI version comprise the inclusion of new antimicrobial agents, adaptation of the ranges of concentrations to cover the EUCAST breakpoints and epidemiological cutoff values (ECOFFs), and the inference of new resistance mechanisms. This proposal should be considered by different manufacturers and users when designing new panels or cards. In addition, recommendations for selective reporting are also included. With this approach, the implementation of EUCAST breakpoints will be easier, increasing the quality of antimicrobial susceptibility testing data and their microbiological interpretation. It will also benefit epidemiological surveillance studies as well as the clinical use of antimicrobials aligned with antimicrobial stewardship programs.

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Section: Discussionmentioning

confidence: 99%

Recommendations of the Spanish Antibiogram Committee (COESANT) for selecting antimicrobial agents and concentrations for in vitro susceptibility studies using automated systems

Oliver

Alós

Benito

et al. 2020

Enfermedades Infecciosas y Microbiología Clínica

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“…They had previously followed the criteria of the American Clinical and Laboratory Standard Institute (CLSI) for this purpose. Comparison of the resistance data obtained using each set of criteria may be useful in the development of a consensus on the most appropriate and clinically relevant breakpoints [5,6].…”

Section: Introductionmentioning

confidence: 99%

Antibiotic Resistance Changes in Gram-Positive Bacteria from Urine Cultures: Development Analysis in a Health Area of South-East Spain

Fernández-Espigares,

Hernández-Chico,

Expósito-Ruiz

et al. 2023

Antibiotics

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This study analyzed the epidemiology and antibiotic susceptibility profile of significant bacteriuria and assessed the impact of adopting EUCAST criteria on antibiotic resistances. A systematic review was performed on publications in English or Spanish between 1 January 2010 and 30 June 2021 on the susceptibility of Gram-positive bacteria isolated in urinary samples in Europe. A retrospective descriptive study was also conducted on the results of 21,838 urine cultures with presumptive urinary tract infection (UTI) obtained during the past five years by the Department of Microbiology of the Virgen de las Nieves University Hospital (Granada, Spain). The activity of various antibiotics was determined, differentiated among various populations, and interpretations compared according to the application of EUCAST or CLSI criteria. Among 21,838 cases of significant bacteriuria, 27.69% were by Gram-positive bacteria, which were Enterococcus faecalis in 19.04% and Enterococcus faecium in 3.92%. The susceptibility profile remained stable for most antibiotics except for levofloxacin for E. faecalis and Staphylococcus aureus and nitrofurantoin for E. faecium. The resistance of Enterococcus spp. and Staphylococcus spp. to glycopeptides was exceptionally low in our setting. No significant difference in the prevalence of methicillin-resistant Staphylococcus aureus was observed between hospital (26.67%) and community (28.85%) samples. Resistances in our local setting remain stable and appear to be lower than reported in other studies. The adoption of EUCAST vs. CLSI criteria did not produce a general change in resistance rates. Findings suggest the need to revise certain empirical criteria, such as aminoglycoside synergy for Enterococcus and for community-origin S. aureus.

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“…The susceptibility comparisons generally reported higher resistance rates with EUCAST breakpoints, which our own findings supported [10], and all articles about EUCAST implementation were from Europe, focusing mainly on the history and structure of EUCAST, organizational differences with CLSI, and EUCAST breakpoint-setting and disk-diffusion methodologies. One recent article [14] proposes a roadmap for transitioning from CLSI to EUCAST in Spanish laboratories, providing useful general recommendations and highlighting differences between CLSI and EUCAST such as antimicrobial disk contents and media. However, its broader utility may be limited as it is specifically orientated towards Spanish laboratories and is available only in Spanish.…”

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confidence: 99%