Delamination of Tantalum Porous Coating From a TKA Due to Regional Dissemination of Debris

Bonutti, Peter M.; Pivec, Robert; Issa, Kimona; Kapadia, Bhaveen H.; Banerjee, Samik; Harwin, Steven F.; Mont, Michael A.; Bauer, Thomas W.

doi:10.3928/01477447-20130724-03

Cited by 8 publications

(4 citation statements)

References 12 publications

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“…23 Zhu et al 4 reported a release of ,2 μg/L Ta from Ta films deposited on sand-blasted, large grit, and acid etched (SLA) Ti surfaces after immersion in PBS for 28 days. Bonutti et al 24 reported a case of metallosis following a total knee arthroplasty (TKA) that used a porous Ta tibial knee component. The patient's operation employed a revised TKA, and delamination of the tibial component was found.…”

Section: Introductionmentioning

confidence: 99%

Involvement of autophagy in tantalum nanoparticle-induced osteoblast proliferation

Kang¹,

Wei²,

Song³

et al. 2017

IJN

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Porous tantalum (Ta) implants are highly corrosion resistant and biocompatible, and they possess significantly better initial stability than that of conventional titanium (Ti) implants. During loading wear, Ta nanoparticles (Ta-NPs) that were deposited on the surface of a porous Ta implant are inevitably released and come into direct contact with peri-implant osteoblasts. The wear debris may influence cell behavior and implant stabilization. However, the interaction of Ta-NPs with osteoblasts has not been clearly investigated. This study aimed to investigate the effect of Ta-NPs on cell proliferation and their underlying mechanism. The Cell Counting Kit-8 (CCK-8) assay was used to measure the cell viability of MC3T3-E1 mouse osteoblasts and showed that Ta-NP treatment could increase cell viability. Then, confocal microscopy, Western blotting, and transmission electron microscopy were used to confirm the autophagy induced by Ta-NPs, and evidence of autophagy induction was observed as positive LC3 puncta, high-LC3-II expression, and autophagic vesicle ultrastructures. The CCK-8 assay revealed that the cell viability was further increased and decreased by the application of an autophagy inducer and inhibitor, respectively. In addition, pre-treatment with autophagy inhibitor 3-methyladenine (3-MA) inhibited the Ta-NP-induced autophagy. These results indicate that the Ta-NPs can promote cell proliferation, that an autophagy inducer can further strengthen this effect and that an autophagy inhibitor can weaken this effect. In conclusion, autophagy was involved in Ta-NP-induced cell proliferation and had a promoting effect.

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Section: Introductionmentioning

confidence: 99%

Involvement of autophagy in tantalum nanoparticle-induced osteoblast proliferation

Kang¹,

Wei²,

Song³

et al. 2017

IJN

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“…There are simply many more examples of THA trunnionosis to observe and collect data on. However, while this may be true there is at least some evidence that the prevalence of trunnionosis in TKA may be larger than currently reported [23][24][25][26][27][28] . The underreporting of trunnionosis in TKA only amplifies the growing disparity in the literature regarding trunnionosis in TKA vs THA.…”

Section: Why Trunnionosis Is Studied Less In Tka Vs Thamentioning

confidence: 76%

“…The treatment for trunnionosis in TKA is similar to that of THA [18] . The prosthetic removal, the soft tissue debridement for those regions affected by ARMD, and the subsequent revision is the mainstay of treatment [4,23,24] .…”

Section: Similarities Of Trunnionosis Between Tka and Thamentioning

confidence: 99%

Trunnionosis in Total Knee Arthroplasty: Is it a clinical problem?

Pulido

Kester

Schwarzkopf

2017

International Journal of Orthopaedics

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Modularity of prosthetic implants is increasingly being utilized for the optimization and personalization of components in total hip and knee arthroplasty. However, due to the increasing number of modular implants being utilized, an adverse event termed trunnionosis has gained prevalence. Trunnionosis is defined as corrosion and wear of the taper junction in modular prostheses. It is postulated that this corrosive wear generates metal debris, which leads to component failure and requires revision of the prosthetic implant. The process of trunnionosis has been extensively studied in total hip arthroplasty. However, few studies have examined the process of trunnionosis in total knee arthroplasty. The aim of this review is to examine the literature regarding trunnionosis following total knee arthroplasty. Specifically, we aim to determine if trunnionosis following total knee arthroplasty is a rare clinical problem, or one that deserves greater attention.

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“…Additionally, with increasing porous Ta implantation duration, the Ta particle content in rat bone tissues shows a gradual upward trend. Research by Fokter and Bonutti also reported that during clinical follow‐ups after porous Ta implantation, [ 35,36 ] X‐ray images showed high‐signal granular materials, and black granular deposits were observed during surgery under direct vision. Therefore, Understanding how Ta particles affect bone metabolism and their interaction with bone remodeling and disease is critical for the long‐term efficacy of porous Ta implants.…”

Section: Resultsmentioning

confidence: 98%

Tantalum Particles Promote M2 Macrophage Polarization and Regulate Local Bone Metabolism via Macrophage‐Derived Exosomes Influencing the Fates of BMSCs

Yang,

Gong,

et al. 2024

Adv Healthcare Materials

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In this study, we explored the regulatory role and mechanisms of tantalum (Ta) particles in the bone tissue microenvironment. Ta particle deposition occurs in both clinical samples and animal tissues following porous Ta implantation. Unlike titanium (Ti) particles promoting M1 macrophage (Mϕ) polarization, Ta particles regulating calcium signaling pathways and promoting M2 Mϕ polarization. Ta‐induced M2 Mϕ enhance bone marrow‐derived mesenchymal stem cells (BMSCs) proliferation, migration, and osteogenic differentiation through exosomes (Exo) by upregulating miR‐378a‐3p/miR‐221‐5p and downregulating miR‐155‐5p/miR‐212‐5p. Ta particles suppress pro‐inflammatory and bone resorption effects of Ti particles in vivo and in vitro. In a rat femoral condyle bone defect model, artificial bone loaded with Ta particles promotes endogenous Mϕ polarization towards M2 differentiation at the defect site, accelerating bone repair. In conclusion, Ta particles modulate Mϕ polarization towards M2 and influence BMSCs osteogenic capacity through Exo secreted by M2 Mϕ, providing insights for potential bone repair applications.This article is protected by copyright. All rights reserved

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Delamination of Tantalum Porous Coating From a TKA Due to Regional Dissemination of Debris

Cited by 8 publications

References 12 publications

Involvement of autophagy in tantalum nanoparticle-induced osteoblast proliferation

Involvement of autophagy in tantalum nanoparticle-induced osteoblast proliferation

Trunnionosis in Total Knee Arthroplasty: Is it a clinical problem?

Tantalum Particles Promote M2 Macrophage Polarization and Regulate Local Bone Metabolism via Macrophage‐Derived Exosomes Influencing the Fates of BMSCs

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