Delay in natural decline of lactase activity in the small intestine of prematurely weaned rats as related to changes in their thyroid status

Shinder, D.; Rakhimov, K; Usmanova, O.D.

doi:10.1016/0300-9629(95)00028-6

Cited by 6 publications

(2 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are a lot of factors involved in developing the activities of disaccharidase during the postnatal period. The involvement of EGF, thyroxine and secretin in postnatal maturation of intestinal sucrase, lactase and maltase are known [11,15,26]. Dietary fiber also induced development of maltase in suckling animals [14,29].…”

Section: Discussionmentioning

confidence: 99%

Influence of Age on Duodenal Brush Border Membrane and Specific Activities of Brush Border Membrane Enzymes in Wistar Rats.

Jang

Jung

Cho³

2000

Exp. Anim.

View full text Add to dashboard Cite

Abstract:To examine age-related changes in the morphology of intestinal brush border membrane (BBM; microvilli) and specific activities of intestinal BBM enzymes including alkaline phosphatase (ALP), γ-glutamyl transpeptidase (γ-GT), and disacchridase, four groups of Wistar rats were sacrificed at 2.5 wk, 5 wk, 5 mon and 23 mon. In an electron microscopic examination, morphologically a less dense BBM structure in the duodenum of rats aged 23 mon was observed than that of rats aged 5 mon. Specific activity of ALP in the duodenum from 5-mon-old rats was significantly higher than from rats aged 2.5 wk and 23 mon. The mucosal tissues from 5-wk-old rats had significantly higher specific activity of γ-GT than did tissues from the other ages. In sucrase and maltase specific activities, 5-mon-old rats had higher activities of these enzymes than other age groups, especially 2.5-wk-and 23-mon-old rats. There was also a significant effect of site on intestinal BBM enzyme activities in post-weanling rats. Regional gradients of ALP and γ-GT along the entire small intestine (duodenum>jejunum>ileum) were remarkable. Disaccharidase activities peaked in the jejunum and declined toward both the duodenum and ileum. Taken together the result obtained here suggested that 5-mon-old rats had the most elevated intestinal function. This result also strongly indicated that the structure of the intestinal BBM and development of intestinal BBM enzymes in Wistar rats were markedly influenced by age during the postnatal period. Key words: age, ALP, disaccharidase, γ-GT, microvilli the organs [4,13,23,31]. Among various organs, the epithelial cells lining the lumen of the gut are the first membrane barrier between the outside environment and the inside circulator in response to external and internal stimuli. The major mechanism associated with absorp-

show abstract

Section: Discussionmentioning

confidence: 99%

Influence of Age on Duodenal Brush Border Membrane and Specific Activities of Brush Border Membrane Enzymes in Wistar Rats.

Jang

Jung

Cho³

2000

Exp. Anim.

View full text Add to dashboard Cite

show abstract

“…Stimulation of jejunal lactase activity by oral IGF‐1 administration to suckling rat pups has been reported (4). Exogenous hormones, such as corticosterone and thyroxine, administered by various means to rodents during the second postnatal week have been shown to induce the precocious appearance of sucrase activities accompanied by an early decline in lactase activity (36‐38). Exogenous IGF‐1 treatment in the present study had no effect on lactase and sucrase activities.…”

Section: Discussionmentioning

confidence: 99%

Diet Fat and Oral Insulin‐Like Growth Factor Influence the Membrane Fatty Acid Composition of Suckling Rat Small Intestine

Kit,

Thomson,

Clandinin

1999

J. pediatr. gastroenterol. nutr.

View full text Add to dashboard Cite

Background:Insulin‐like growth factor‐1 plays an important role in small intestine development. The presence of insulin‐like growth factor‐1 and the complexity of the fatty acid composition in breast milk suggests that intestinal development may be influenced by manipulating the levels of these components.Methods:To determine whether a physiological dose of insulin‐like growth factor‐1 would influence sucrase and lactase activity levels, 10‐day‐old suckling rat pups were treated with an oral gavage of insulin‐like growth factor‐1. Four diets differing in fat composition were fed to lactating dams. Brush border membranes were isolated from jejunal and ileal segments of suckling rat small intestine. Fatty acid analysis of choline and ethanolamine phospholipids was performed.Results:Insulin‐like growth factor‐1 was found to have no effect on the sucrase and lactase activities of suckling rats. Changes in the diet fat composition of the mother's diet indirectly influenced the fatty acid composition of suckling rat small intestine. Insulin‐like growth factor‐1 decreased ileal C20:4n‐6 levels. A correlation was observed between lactase activity and C20:4n‐6 and C22:6n‐3 levels. As C20:4n‐6 levels increased, lactase activity appeared to decline. Increased lactase activity was observed when C22:6n‐3 levels increased.Conclusions:The changes observed in C20:4n‐6 levels in response to oral insulin‐like growth factor‐1, combined with the apparent trend of increased lactase activity with declining levels of C20:4n‐6, may be of significance in the development of the small intestine in early life.

show abstract

Early age cold conditioning in broiler chickens (Gallus domesticus): thermotolerance and growth responses

Shinder¹,

Luger²,

Rusal³

et al. 2002

Journal of Thermal Biology

View full text Add to dashboard Cite

Delay in natural decline of lactase activity in the small intestine of prematurely weaned rats as related to changes in their thyroid status

Cited by 6 publications

References 13 publications

Influence of Age on Duodenal Brush Border Membrane and Specific Activities of Brush Border Membrane Enzymes in Wistar Rats.

Influence of Age on Duodenal Brush Border Membrane and Specific Activities of Brush Border Membrane Enzymes in Wistar Rats.

Diet Fat and Oral Insulin‐Like Growth Factor Influence the Membrane Fatty Acid Composition of Suckling Rat Small Intestine

Early age cold conditioning in broiler chickens (Gallus domesticus): thermotolerance and growth responses

Contact Info

Product

Resources

About