2021
DOI: 10.21203/rs.3.rs-151044/v1
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Delay in Primordial Germ Cell Migration in Adamts9 Knockout Zebrafish

Abstract: Adamts9 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 9) is one of few metalloproteinases structurally conserved from C. elegans to humans and is indispensable in germ cell migration in invertebrates. However, adamts9’s roles in germ cell migration in vertebrates has not been examined. In the present study, we found zygotic expression of adamts9 started around germ ring stage and reached peak levels at 3 days post fertilization (dpf) in zebrafish. Germ cell migration completed… Show more

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“…Analysis of Adamts9 null embryos, embryos homozygous for an Adamts9 hypomorphic gene-trap allele and of Adamts9 conditional mouse mutants has identified essential roles for ADAMTS9 in gastrulation, cardiovascular, eye and umbilical cord development, and together with ADAMTS20, in neural tube and palate closure, interdigital web regression and skin pigmentation (10)(11)(12)(13)(15)(16)(17)(18)(19). In worms, ADAMTS9 is implicated in gonad development (20, 21), in flies in tracheal, salivary gland and germ cell development (22) and in zebrafish, early germ cell migration and ovarian development (23,24).…”
Section: In Briefmentioning
confidence: 99%
“…Analysis of Adamts9 null embryos, embryos homozygous for an Adamts9 hypomorphic gene-trap allele and of Adamts9 conditional mouse mutants has identified essential roles for ADAMTS9 in gastrulation, cardiovascular, eye and umbilical cord development, and together with ADAMTS20, in neural tube and palate closure, interdigital web regression and skin pigmentation (10)(11)(12)(13)(15)(16)(17)(18)(19). In worms, ADAMTS9 is implicated in gonad development (20, 21), in flies in tracheal, salivary gland and germ cell development (22) and in zebrafish, early germ cell migration and ovarian development (23,24).…”
Section: In Briefmentioning
confidence: 99%