Delay of the First Onset of Pouchitis by Oral Intake of the Probiotic Strain Lactobacillus rhamnosus GG

Gosselink, M.; Schouten, W. R.; Lieshout, L. M. C. Van; Hop, W. C. J.; Laman, Jon D.; Embden, J. G. H. Ruseler-Van

doi:10.1007/s10350-004-0525-z

Cited by 198 publications

(76 citation statements)

References 51 publications

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“…A specific probiotic has been found to modulate the expression of genes involved in cell growth and differentiation in the intestinal mucosa of human volunteers [27] . Probiotics have also been successfully applied in patients with IBD [28,29] or diverticulitis [30] . Several studies indicate that aberrancies in faecal microbiota are present in different diseases, and our results strengthen those studies with colonic mucosa data.…”

Section: Discussionmentioning

confidence: 99%

Qualitative and quantitative analyses of the bifidobacterial microbiota in the colonic mucosa of patients with colorectal cancer, diverticulitis and inflammatory bowel disease

Gueimonde

Ouwehand²,

Huhtinen³

et al. 2007

WJG

110

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AIM:To characterize the bifidobacterial microbiota of the colonic mucosa in patients with colon cancer, inflammatory bowel disease or diverticulitis. METHODS:A sample of the distal colonic mucosa was taken during surgery from a total of 34 patients, twenty-one with diagnosed colorectal cancer, nine with diverticulitis and four with inflammatory bowel disease, requiring surgery for their condition. Bacterial DNA was extracted from the resected mucosal samples and bifidobacterial mucosa-associated microbiota was qualitatively and quantitatively determined by means of qualitative and quantitative PCR. RESULTS:Bifidobacteria were found in 100% of the samples from patients with diverticulitis or IBD and a 76% of those suffering colon cancer. The species B. longum and B. bifidum were the most widely found, followed by B. animalis , B. catenulatum and B. adolescentis . B. breve , B. dentium and B. angulatum were not detected in any sample. A significantly higher occurrence of B. longum was observed in patients with diverticulitis than in those with colon cancer or IBD (100%, 62% and 75%, respectively, P < 0.05). Similar results were obtained for B. animalis (56%, 0% and 25%, P < 0.05), while B. adolescentis was only found in the mucosa from patients with colon cancer (5 out of 21, 24%). At the quantitative level, patients with colon cancer or IBD showed lower counts of total Bifidobacterium (4.94 and 5.91 vs 6.96 log Cells/sample, respectively, P < 0.05) and of the species B. longum (4.05 and 4.79 vs 6.76, P < 0.05) than those with diverticulitis. CONCLUSION:Aberrancies in mucosa associated microbiota are present in different intestinal diseases. This may indicate a role of the microbiota in the pathogenesis of these diseases.

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Section: Discussionmentioning

confidence: 99%

Qualitative and quantitative analyses of the bifidobacterial microbiota in the colonic mucosa of patients with colorectal cancer, diverticulitis and inflammatory bowel disease

Gueimonde

Ouwehand²,

Huhtinen³

et al. 2007

WJG

110

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“…Clinical trials of probiotic treatment for inflammatory bowel disease, however, have yielded conflicting results. Some of them have confirmed the claim that a daily intake of probiotics will delay the first onset of pouchitis and that they are effective in the treatment of active Crohn's disease [10,11] while others failed to a show a beneficial affect [12] .…”

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confidence: 72%

Probiotics for Antibiotic-Associated Diarrhea – Maybe, Maybe Not!

Lubetzky¹,

Reif²

2008

Digestion

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“…From etiological and pathogenetic perspectives, a variety of factors may contribute to the initiation, development, and progression of the disease. These factors include genetic predisposition, 20,21 dysbiosis, 1-4 altered mucosal immunity, [22][23][24][25][26][27][28] and colonic metaplasia due to fecal stasis, 29,30 A previous study demonstrated that a decreased intramucosal pH with mucosal acidosis characteristic of hypoperfusion was associated with an increased risk for the development of pouchitis. 15 The findings of the current study suggest that pouchitis with endoscopic asymmetric inflammation may be associated with ischemic factors.…”

Section: Discussionmentioning

confidence: 97%

Asymmetric endoscopic inflammation of the ileal pouch: A sign of ischemic pouchitis?

Shen¹,

Plesec²,

Remer³

et al. 2010

Inflammatory Bowel Diseases

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Delay of the First Onset of Pouchitis by Oral Intake of the Probiotic Strain Lactobacillus rhamnosus GG

Abstract: Daily intake of fermented products containing L. rhamnosus GG provides significant clinical benefit, without side effects. Based on the results of this study, we recommend a daily intake of Lactobacillus rhamnosus GG (dose 1-2 x 10(10) bacteria) to delay the first onset of pouchitis.

Cited by 198 publications

References 51 publications

Qualitative and quantitative analyses of the bifidobacterial microbiota in the colonic mucosa of patients with colorectal cancer, diverticulitis and inflammatory bowel disease

Qualitative and quantitative analyses of the bifidobacterial microbiota in the colonic mucosa of patients with colorectal cancer, diverticulitis and inflammatory bowel disease

Probiotics for Antibiotic-Associated Diarrhea – Maybe, Maybe Not!

Asymmetric endoscopic inflammation of the ileal pouch: A sign of ischemic pouchitis?

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