Delayed behavioral effects of β-casomorphin-7 depend on age and gender of albino rat pups

Health-Related Outcomes and Molecular Methods for the Characterization of A1 and A2 Cow’s Milk: Review and Update

“…In a bibliometrics and text mining study initiated by Gonzales-Malca et al [7], the authors of a studied cluster found a link between BCM-7 and autism in children [90]. Additionally, they discovered that BCM-7 had a positive effect on the behavior and learning of rats, as evidenced by previous studies [91][92][93][94]. This connection was confirmed through the detection of bovine BCM-7 in autistic children's urine, employing a highly sensitive ELISA technique [88].…”

10.1007/s10525-008-1007-y

“…The pattern of changes is similar after their chronic administration during early postnatal period. The delayed consequences of repeated administration of, primarily, β -casomorphin-7 to the pups are very similar to the effect of its single administration (also to adult animals): increased exploratory activity and decreased anxiety (Dubynin et al, 2000) as well as improved learning with positive reinforcement and impaired learning with negative reinforcement demonstrated in this work. Hence, the peptide administration during early postnatal period pushes the nervous system development in the same direction as in adult rats.…”

“…For instance, heptapeptide β -casomorphin-7 increased the exploratory activity, decreased the anxiety, and attenuated the behavioral manifestations of depression (elevated plus maze test, forest swimming test, etc.). The drug effects depended on the time of administration (postnatal days 1-14, 10-23, or 21-35; 1 mg/kg daily), which clearly depended on the maturation dynamics of the rat brain opioid system (Dubynin et al, 2000). Animals administered β -casomorphin-7 also demonstrated increased serotonin level in the cerebral hemisphere cortex (Dubynin et al, 1999).…”