Delayed Correction for Extrapolation in Amblyopia

Wang, Xi; Li, Meng; Song, Yutong; Liu, Longqian; Reynaud, Alexandre

doi:10.1167/iovs.62.15.20

Cited by 1 publication

(2 citation statements)

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“…Actually, by using the FLE and the FGE, we previously investigated how the amblyopic visual system implements motion extrapolation within the monocular visual processing stage. 23 , 24 In addition, we also found that patients with amblyopia exhibit a smaller FLE and a larger FGE both in their AE and FE. Such reduced FLE would characterize less anticipation of the position of the moving object along its trajectory.…”

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Interocular Transfer: The Dichoptic Flash-Lag Effect in Controls and Amblyopes

Wang

Song

et al. 2022

Invest. Ophthalmol. Vis. Sci.

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Purpose The mammalian brain can take into account the neural delays in visual information transmission from the retina to the cortex when accurately localizing the instantaneous position of moving objects by motion extrapolation. In this study, we wanted to investigate whether such extrapolation mechanism operates in a comparable fashion between the eyes in normally sighted and amblyopic observers. Methods To measure interocular extrapolation, we adapted a dichoptic version of the flash-lag effect (FLE) paradigm, in which a flashed bar is perceived to lag behind a moving bar when their two positions are physically aligned. Twelve adult subjects with amblyopia and 12 healthy controls participated in the experiment. We measured the FLE magnitude of the subjects under binocular, monocular, and dichoptic conditions. Results In controls, the FLE magnitude of binocular condition was significantly smaller than that of monocular conditions ( P ≤ 0.023), but there was no difference between monocular and dichoptic conditions. Subject with amblyopia exhibited a smaller FLE magnitude in the dichoptic condition when the moving bar was presented to the amblyopic eye and the flash to the fellow eye (DA condition) compared to the opposite way around (DF condition), consistent with a delay in the processing of the amblyopic eye ( P = 0.041). Conclusions Our observations confirm that trajectory extrapolation mechanisms transfer between the eyes of normal observers. However, such transfer may be impaired in amblyopia. The smaller FLE magnitude in DA compared to DF in patients with amblyopia could be due to an interocular delay in the amblyopic visual system. The observation that normal controls present a smaller FLE in binocular conditions raises the question whether a larger FLE is or is not an indicator of better motion processing and extrapolation.

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“…4 A), suggesting impaired motion extrapolation in the amblyopic visual system, consistent with our previous studies using monocular viewing. 23 , 24 In addition, we found a shallower slope of the psychometric function in the AE compared with that in the NDE (see Fig. 4 B).…”

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confidence: 53%