Delayed diagnosis of anaphylaxis secondary to ondansetron

Goyal, Preeti; Paramesh, Kaggere; Puranik, Sarang; Proctor, Mark R.; Sanghvi, Mihir M.

doi:10.1097/eja.0000000000000372

Cited by 6 publications

(3 citation statements)

References 7 publications

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“…Known side effects of ondansetron include confusion, dizziness, constipation, dry mouth, headache, hyperventilation, tachycardia, insomnia, and rarely, hypersensitivity reactions, visual disturbances, chest pain and cardiac arrhythmias . Although there are different cases reporting hypersensitivity reactions to oral and intravenous ondansetron, this side effect is rare and not common . Fixed drug eruptions (FDE) were also reported in association with ondansetron use .…”

Section: Discussionmentioning

confidence: 99%

Pityriasis rosea‐like eruption associated with ondansetron use in pregnancy

Alame

Chamsy

Zaraket

2018

Brit J Clinical Pharma

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A 30-year-old pregnant female presented with a 2-week history of pityriasis rosea-like eruption. The rash started 2 days after the patient had started taking ondansetron 8 mg for alleviation of moderate-to-severe nausea and vomiting of pregnancy. Physical examination revealed erythematous papulosquamous lesions characterized by annular scaly margins and a dusky centre over the arms, chest, abdomen, lower back and legs. The rash did not involve the palms, sole or mucous membranes, and no lesions were observed on the lymph nodes. Ondansetron was discontinued. The rash ceased to spread and started to disappear within 2 weeks with full resolution noted after 1 month. Analysis of the case using the Naranjo adverse drug reaction probability scale indicated that ondansetron was the probable cause of the pityriasis rosea-like eruption. This is the first case report of pityriasis rosea related to ondansetron therapy.

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Section: Discussionmentioning

confidence: 99%

Pityriasis rosea‐like eruption associated with ondansetron use in pregnancy

Alame

Chamsy

Zaraket

2018

Brit J Clinical Pharma

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“…Life-threatening adverse reactions have been uncommonly reported, and may be secondary to coronary vasospasm, hypotension and generalized tonic-clonic seizures [3,4,9]. The incidence of anaphylaxis to ondansetron is low and fatal evolution is exceptional [1,[10][11][12][13]. This has prompted some authors to suggest that ondansetron's use should be restricted in cases of anaphylaxia [14].…”

Section: Discussionmentioning

confidence: 99%

Fatal anaphylactic reaction to intravenous infusion of Ondansetron: a report of two cases

Ouni¹,

Bensayed²,

Fathallah³

et al. 2017

IJP

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“…2 We found 7 cases reports of allergic reactions to ondansetron in the literature, 1,2,9-13 , of which 3 involved an IgE-mediated mechanism confirmed by skin prick and/or intradermal tests. 1,9,10 Two of these 3 occurred in pediatric patients. Tan et al described a case of anaphylaxis after initial sublingual administration of ondansetron in a 12-year-old child, and an IgEassociated mechanism was confirmed through intradermal tests.…”

Section: Discussionmentioning

confidence: 99%

Anaphylactic reaction to ondansetron in a pediatric patient: a rare case report

Santos,

Gouveia,

Gomes

2023

AAAI

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Ondansetron é um medicamento antiemético amplamente utilizado, mas a hipersensibilidade ao mesmo é rara. Apresentamos um caso clínico de uma criança com anafilaxia após tomar dose única de ondansetron, via oral, onde se demonstra um mecanismo mediado por IgE através de testes intradérmicos positivos.Descritores: Anafilaxia, relatos de casos, antieméticos, pediatria.Although ondansetron is a widely used antiemetic medication, hypersensitivity to ondansetron is rare. We report a clinical case of a child who had an anaphylactic reaction after a single oral dose of ondansetron. An immunoglobulin E-mediated mechanism was determined by positive intradermal tests.

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Delayed diagnosis of anaphylaxis secondary to ondansetron

Cited by 6 publications

References 7 publications

Pityriasis rosea‐like eruption associated with ondansetron use in pregnancy

Pityriasis rosea‐like eruption associated with ondansetron use in pregnancy

Fatal anaphylactic reaction to intravenous infusion of Ondansetron: a report of two cases

Anaphylactic reaction to ondansetron in a pediatric patient: a rare case report

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