Delayed diagnosis of Brugada syndrome in a patient with aborted sudden cardiac death and initial negative flecainide challenge

Chauveau, Samuel; Vavasseur, Olivier Le; Chevalier, Philippe

doi:10.1002/ccr3.1198

Cited by 10 publications

(3 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[13][14][15] Provocative testing can be helpful to identify patients; however, limitations exist as nearly 25% of drug-induced tests might be false negatives. [16][17][18] Further, the "provoked phenotype" might be somewhat of a misnomer especially from the standpoint of risk stratification as many of these patients develop a spontaneous type 1 pattern during follow-up.…”

Section: Discussionmentioning

confidence: 99%

“… 13 , 14 , 15 Provocative testing can be helpful to identify patients; however, limitations exist, as nearly 25% of drug-induced tests might be false-negatives. 16 , 17 , 18 Further, the “provoked phenotype” might be somewhat of a misnomer, especially from the standpoint of risk stratification, as many of these patients develop a spontaneous type 1 pattern during follow-up. Over the course of our follow-up period, we identified a higher rate of spontaneous type 1 ECG findings than a prior Holter monitoring study that analyzed ECG changes over a significantly shorter duration.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Longitudinal electrocardiographic assessment in Brugada syndrome

Daw¹,

Chahal²,

Arkles

et al. 2022

Heart Rhythm O2

View full text Add to dashboard Cite

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Longitudinal electrocardiographic assessment in Brugada syndrome

Daw¹,

Chahal²,

Arkles

et al. 2022

Heart Rhythm O2

View full text Add to dashboard Cite

show abstract

“… 11 Channelopathies, which typically present in younger patients, are essential to recognize as they carry a risk of sudden death. 12 , 13 Among these patients, arrhythmic syncope is relatively rare 14 , 15 with other more benign aetiological forms being more common, nevertheless still presenting diagnostic difficulties.…”

Section: Introductionmentioning

confidence: 99%

Definitive aetiology of unexplained syncope after cardiovascular autonomic tests in a tertiary syncope unit

Torabi,

Hamrefors,

Sutton

et al. 2023

Europace

View full text Add to dashboard Cite

Background and aim Syncope is a common condition with many possible causes, ranging from benign to life-threatening aetiologies. Establishing a diagnosis can be difficult and specialized syncope units, using cardiovascular autonomic tests (CAT) including head-up tilt test can increase the diagnostic yield. However, up to one fifth of examined patients have inconclusive CAT results. The aim of the present study was to investigate the predictive value of history and clinical findings for unexplained syncope after CAT and characterize the group with negative results. Methods and results Consecutive syncope patients (n = 2663, 61% women, median age 52 [32-69] years) were evaluated and CAT explained aetiology of syncope in 79% of cases, whereas 21% remained unexplained. Predictors of negative CAT were older age at first syncope (+8% higher odds per 10-year increment, p = 0.042), higher supine HR (+12% per 10 beat-per-minute; p = 0.003), absence of prodromes (+48%; p < 0.001), hypertension (+45%; p = 0.003), diabetes (+82%; p < 0.001), heart failure (+98%; p = 0.014) and coronary artery disease (+51%; p = 0.027). Compared with vasovagal syncope, patients with negative CAT were older, reported more often absence of prodromes and had a higher burden of cardiovascular comorbidities. Conclusion Cardiovascular autonomic testing established cause of syncope in 79% of patients evaluated in a syncope unit. Syncope without prodromes and cardiovascular comorbidities were significant predictors of failure to reveal an aetiology from assessment by CAT. These are known risk factors for cardiac syncope and patients with inconclusive CAT warrant further investigation.

show abstract

Specific Cardiovascular Diseases and Competitive Sports Participation: Channelopathies

Castelletti

Crotti

2020

Textbook of Sports and Exercise Cardiology

View full text Add to dashboard Cite

Delayed diagnosis of Brugada syndrome in a patient with aborted sudden cardiac death and initial negative flecainide challenge

Cited by 10 publications

References 6 publications

Longitudinal electrocardiographic assessment in Brugada syndrome

Longitudinal electrocardiographic assessment in Brugada syndrome

Definitive aetiology of unexplained syncope after cardiovascular autonomic tests in a tertiary syncope unit

Specific Cardiovascular Diseases and Competitive Sports Participation: Channelopathies

Contact Info

Product

Resources

About