Delayed early developmental trajectories of white matter tracts of functional pathways in preterm-born infants: Longitudinal diffusion tensor imaging data

Chang, Linda; Akazawa, Kentaro; Yamakawa, Robyn; Hayama, Sara; Buchthal, Steven; Alicata, Daniel; Andres, Tamara; Castillo, Deborrah; Oishi, Kumiko; Skranes, Jon; Ernst, Thomas; Oishi, Keiji

doi:10.1016/j.dib.2016.01.064

Cited by 11 publications

(7 citation statements)

References 4 publications

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“…During this second stage, there is a decrease in overall water diffusivity as glial cells and oligodendrocyte lineage precursors multiply 46 . Considering this chronology and its reflection in DTI measures allowed us to take a more objective look at the impact of prematurity on each specific region of the CC when measuring the developmental growth trajectory 22 , 24 , 50 , 51 .…”

Section: Discussionmentioning

confidence: 99%

Postnatal Microstructural Developmental Trajectory of Corpus Callosum Subregions and Relationship to Clinical Factors in Very Preterm Infants

Teli

Hay

Hershey

et al. 2018

Sci Rep

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Our objectives were to define the microstructural developmental trajectory of six corpus callosum subregions and identify perinatal clinical factors that influence early development of these subregions in very preterm infants. We performed a longitudinal cohort study of very preterm infants (32 weeks gestational age or younger) (N = 36) who underwent structural MRI and diffusion tensor imaging serially at four time points - before 32, 32, 38, and 52 weeks postmenstrual age. We divided the corpus callosum into six subregions, performed probabilistic tractography, and used linear mixed effects models to evaluate the influence of antecedent clinical factors on its microstructural growth trajectory. The genu and splenium demonstrated the most rapid developmental maturation, exhibited by a steep increase in fractional anisotropy. We identified several factors that favored greater corpus callosum microstructural development, including advancing postmenstrual age, higher birth weight, and college level or higher maternal education. Bronchopulmonary dysplasia, low 5-minute Apgar scores, caffeine therapy/apnea of prematurity and male sex were associated with reduced corpus callosum microstructural integrity/development over the first six months after very preterm birth. We identified a unique postnatal microstructural growth trajectory and associated clinical factor profile for each of the six corpus callosum subregions that is consistent with the heterogeneous functional role of these white matter subregions.

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Section: Discussionmentioning

confidence: 99%

Postnatal Microstructural Developmental Trajectory of Corpus Callosum Subregions and Relationship to Clinical Factors in Very Preterm Infants

Teli

Hay

Hershey

et al. 2018

Sci Rep

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“…A neonatal brain MRI database from a longitudinal study of early brain development was used. Written and verbal informed consent were provided by the infants' parents or legal guardians, in accordance with the Cooperative Institutional Review Board (IRB) of the Queen's Medical Center, the University of Hawaii, and the Johns Hopkins University.…”

Section: Methodsmentioning

confidence: 99%

A Multi‐Atlas Label Fusion Tool for Neonatal Brain MRI Parcellation and Quantification

Otsuka

Chang

Kawasaki

et al. 2019

Journal of Neuroimaging

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Structure-by-structure analysis, in which the brain magnetic resonance imaging (MRI) is parcellated based on its anatomical units, is widely used to investigate chronological changes in morphology or signal intensity during normal development, as well as to identify the alterations seen in various diseases or conditions. The multi-atlas label fusion (MALF) method is considered a highly accurate parcellation approach, and anticipated for clinical application to quantitatively evaluate early developmental processes. However, the current MALF methods, which are designed for neonatal brain segmentations, are not widely available. In this study, we developed a T1-weighted, neonatal, multi-atlas repository and integrated it into the MALF-based brain segmentation tools in the cloud-based platform, MRICloud. The cloud platform ensures users instant access to the advanced MALF tool for neonatal brains, with no software or installation requirements for the client. The Web platform by braingps.mricloud.org will eliminate the dependence on a particular operating system (eg, Windows, Macintosh, or Linux) and the requirement for high computational performance of the user's computers. The MALF-based, fully automated, image parcellation could achieve excellent agreement with manual parcellation, and the whole and regional brain volumes quantified through this method demonstrated developmental trajectories comparable to those from a previous publication. This solution will make the latest MALF tools readily available to users, with minimum barriers, and will expedite and accelerate advancements in developmental neuroscience research, neonatology, and pediatric neuroradiology.

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“…Brain MRI data were obtained from infants recruited and scanned at the University of Hawaii and the Queen’s Medical Center MR Research Center in Honolulu, HI, as described in our prior work (Akazawa et al, 2016; Chang et al, 2016). The infants’ parents or legal guardians provided written and verbal informed consent for the study, which was approved by the Cooperative Institutional Review Board (IRB) of the Queen’s Medical Center and the University of Hawaii, as well as the IRB at the Johns Hopkins University.…”

Section: Methodsmentioning

confidence: 99%

Mapping the critical gestational age at birth that alters brain development in preterm-born infants using multi-modal MRI

Chang

Akazawa

et al. 2017

NeuroImage

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Preterm birth adversely affects postnatal brain development. In order to investigate the critical gestational age at birth (GAB) that alters the developmental trajectory of gray and white matter structures in the brain, we investigated diffusion tensor and quantitative T2 mapping data in 43 term-born and 43 preterm-born infants. A novel multivariate linear model—the change point model, was applied to detect change points in fractional anisotropy, mean diffusivity, and T2 relaxation time. Change points captured the “critical” GAB value associated with a change in the linear relation between GAB and MRI measures. The analysis was performed in 126 regions across the whole brain using an atlas-based image quantification approach to investigate the spatial pattern of the critical GAB. Our results demonstrate that the critical GABs are region- and modality-specific, generally following a central-to-peripheral and bottom-to-top order of structural development. This study may offer unique insights into the postnatal neurological development associated with differential degrees of preterm birth.

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Delayed early developmental trajectories of white matter tracts of functional pathways in preterm-born infants: Longitudinal diffusion tensor imaging data

Cited by 11 publications

References 4 publications

Postnatal Microstructural Developmental Trajectory of Corpus Callosum Subregions and Relationship to Clinical Factors in Very Preterm Infants

Postnatal Microstructural Developmental Trajectory of Corpus Callosum Subregions and Relationship to Clinical Factors in Very Preterm Infants

A Multi‐Atlas Label Fusion Tool for Neonatal Brain MRI Parcellation and Quantification

Mapping the critical gestational age at birth that alters brain development in preterm-born infants using multi-modal MRI

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