Delayed effect of repetitive transcranial magnetic stimulation (rTMS) on negative symptoms of schizophrenia: Findings from a randomized controlled trial

Li, Zhe; Yin, Ming; Lyu, Xiaoli; Zhang, Lanlan; Du, Xiangdong; Hung, Galen Chin‐Lun

doi:10.1016/j.psychres.2016.04.046

Cited by 41 publications

(22 citation statements)

References 9 publications

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“…We analyzed data from 18 studies reporting PANSS total scores derived from 467 patients receiving active rTMS and 350 patients receiving sham treatment [27,28,32,34,35,39,[46][47][48][49][50][51][52][53][54][55][56][57]. There was no significant effect of treatment (Hedge's g = À0.29, p = 0.06) and the level of heterogeneity was high (I 2 = 78.63%).…”

Section: Overall Symptom Severitymentioning

confidence: 99%

Efficacy of non-invasive brain stimulation on the symptom dimensions of schizophrenia: A meta-analysis of randomized controlled trials

2018

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Section: Overall Symptom Severitymentioning

confidence: 99%

Efficacy of non-invasive brain stimulation on the symptom dimensions of schizophrenia: A meta-analysis of randomized controlled trials

2018

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“…It has been observed that the effect of brain stimulation can be delayed [31], with its effect manifesting beyond treatment periods. However, existing research often completed follow-up at the end of treatment.…”

Section: Introductionmentioning

confidence: 99%

Delayed effect of bifrontal transcranial direct current stimulation in patients with treatment-resistant depression: a pilot study

Chu

et al. 2019

BMC Psychiatry

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Background Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique, which has yielded promising results in treating major depressive disorder. However, its effect on treatment-resistant depression remains to be determined. Meanwhile, as an emerging treatment option, patients’ acceptability of tDCS is worthy of attention. Methods This pilot study enrolled 18 patients (wome n = 13) with treatment-resistant unipolar ( n = 13) or bipolar ( n = 5) depression. Twelve sessions of tDCS were administered with anode over F3 and cathode over F4. Each session delivered a current of 2 mA for 30 min per ten working days, and at the 4th and 6th week. Severity of depression was determined by Montgomery–Åsberg Depression Rating Scale (MADRS); cognitive performance was assessed by a computerized battery. Results Scores of MADRS at baseline (29.6, SD = 9.7) decreased significantly to 22.9 (11.7) ( p = 0.03) at 6 weeks and 21.5 (10.3) ( p = 0.01) at 8 weeks. Six (33.3%) participants were therapeutically responsive to tDCS. MADRS scores of responders were significantly lower than those of non-responders at the 6th and 8th week. Regarding change of cognitive performance, improved accuracy of paired association ( p = 0.017) and social cognition ( p = 0.047) was observed at the 8th week. Overall, tDCS was perceived as safe and tolerable. For the majority of patients, it is preferred than pharmacotherapy and psychotherapy. Conclusions TDCS can be a desirable option for treatment-resistant depression, however, its efficacy may be delayed; identifying predictors of therapeutic response may achieve a more targeted application. Larger controlled studies with optimized montages and sufficient periods of observation are warranted. Trial registration This trial has been registered at the Chinese Clinical Trial Registry ( ChiCTR-INR-16008179 ).

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“…Overall, while the positive impact of Switch on usual measures of motivation, apathy and daily functioning was observed in each participant, this was not consistently translated by a change in daily life measurements of motivation and activity, or processes related to motivation and steps. It is plausible that the impact on certain daily life processes (i.e., measured with the ESM) develop on a longer term [44,45], or that the intervention itself would need to last longer in order for some cognitive or hedonic skills to improve for certain individuals. Indeed, the idiosyncratic analyses revealed very different dynamics between those processes and it appears that the intervention impacts each person differently.…”

Section: Discussionmentioning

confidence: 99%

Idiographic analyses of motivation and related processes in participants with schizophrenia following a therapeutic intervention for negative symptoms

et al. 2020

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Background Motivational negative symptoms hinder quality of life and daily functioning of individuals with schizophrenia spectrum disorders. A recently developed intervention, Switch, has shown promising effects on negative symptoms and functional outcomes. Switch targets multiple cognitive, emotional and behavioural processes associated with motivation and goal directed behaviours. We aimed to investigate its effects on motivation and associated processes in a naturalistic setting, and to explore the dynamics between the processes. Methods We used a single case approach (n = 3), with a pre-post and follow-up assessment design, which also included ambulatory assessments (experience sampling method, ESM; and step count). We computed autoregressive lag 1 models to evaluate the effects of the intervention on daily motivation levels and related processes, descriptive pie-charts, and vector autoregressive modelling to reveal the dynamics of the processes over time. Results The intervention was beneficial for each participant according to traditional evaluations of motivational negative symptoms, apathy, daily functioning and quality of life. The effects on the ESM variables revealed distinct outcomes for each individual. The dynamics between the various processes differed between participants, and fluctuated within participants (when comparing baseline, intervention phase, and follow-up). Conclusions This study used an innovative approach to look at the effectiveness of an intervention. The intervention seems to lead to meaningful improvements in motivational negative symptoms and functional outcomes. The mechanisms of change need to be further investigated. Trial registration number ClinicalTrials.gov, NCT04325100. Registered 27 March 27, 2020 -retrospectively registered. Reporting Guidelines from the Transparent Reporting of Evaluations with Non-randomized Designs (TREND) statement were followed.

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Delayed effect of repetitive transcranial magnetic stimulation (rTMS) on negative symptoms of schizophrenia: Findings from a randomized controlled trial

Cited by 41 publications

References 9 publications

Efficacy of non-invasive brain stimulation on the symptom dimensions of schizophrenia: A meta-analysis of randomized controlled trials

Efficacy of non-invasive brain stimulation on the symptom dimensions of schizophrenia: A meta-analysis of randomized controlled trials

Delayed effect of bifrontal transcranial direct current stimulation in patients with treatment-resistant depression: a pilot study

Idiographic analyses of motivation and related processes in participants with schizophrenia following a therapeutic intervention for negative symptoms

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