Delayed emergence of cholinergic inhibitory functioning in undernourished mice

Porada, Kenneth J.; Nagy, Z. Michael

doi:10.1016/s0163-1047(82)90701-4

Cited by 3 publications

(2 citation statements)

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“…Activity increases in response to amphetamine were detected as early as 5 days of age in the present study, while evidence suggests that locomotor responses to the serotonin antagonist methysergide and the anticholinergic scopolamine emerge later during ontogeny in S-W mice. Increased photocell cage crossings following methysergide are not evident until the mice are 13 days old (Porada, 1975), while adult-like cage-crossing responses to scopolamine are not obtained until the mice are approximately 19 days old (Ray & Nagy, 1978). Although the effects of methysergide upon EAM activity had not been investigated, an unpublished study from this laboratory has indicated that agerelated changes in response to scopolamine are nearly identical for EAM activity and photocell cage crossings.…”

Section: Discusssionmentioning

confidence: 99%

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Potentiation of locomotor activity by d-amphetamine in infant Swiss-Webster mice

Forster

Nagy

1983

Psychobiology

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Swiss-Webster mice were tested for locomotor activity in either an electromagnetic field (6,7, or 9 days of age) or photocell shuttle (9, 11, or 13 days of age) apparatus over a 4-h period following systematic injections of d-amphetamine or saline. While d-amphetamine reliably increased activity at all ages tested, the magnitude of the increase varied both as a function of age and apparatus, with younger mice showing a smaller increment than older mice in each apparatus and the electromagnetic field showing relatively greater increments than the photocell apparatus. In addition, amphetamine-induced hyperactivity for the age groups tested was always of longer duration than that reported for adult mice and rats, regardless of the type of apparatus. The present findings for mice are consistent with those that demonstrated that rats respond to amphetamine at early ages and also indicate that both species show similar age differences in the temporal effects of systematically administered amphetamine.

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Section: Discusssionmentioning

confidence: 99%

“…Previous pharmacological studies of the S-W mouse have indicated that serotonergic (Porada, 1975) and cholinergic (Ray & Nagy, 1978) modulation of locomotor activity begin by 13 and 19 days of age, respectively. The detection of locomotor stimulant effects of amphetamine in mice prior to these ages would be consistent with existing data for the developing rat.…”

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confidence: 99%