2016
DOI: 10.1186/s12891-016-1244-z
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Delayed gadolinium-enhanced MRI of meniscus (dGEMRIM) and cartilage (dGEMRIC) in healthy knees and in knees with different stages of meniscus pathology

Abstract: BackgroundLesions in the meniscus are risk factors for developing knee osteoarthritis (OA), not least because of the role of the meniscus in the pathological progression of OA. Delayed gadolinium enhanced MRI of cartilage (dGEMRIC) has extensively been used to identify pre-radiographic cartilage changes in OA. In contrast, its counterpart with regard to examination of the meniscus, gadolinium enhanced MRI of meniscus (dGEMRIM), has been less utilized. In this study we use 3D dGEMRIM in patients with meniscus l… Show more

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Cited by 9 publications
(11 citation statements)
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“…Other groups using the i.v. dGEMRIM approach like Sigurdsson et al found a reverse U‐shaped dGEMRIM patterns at different stages of meniscus lesions with increasing dGEMRIM for the moderate meniscal degenerations degrees that decreased for high grades,, and in a histologic study by Sun et al they found that severe loss of collagen and increasing concentration of proteoglycans were hallmarks of OA degenerated menisci, which is the reverse process of GAG behavior in cartilage. Finally, Krishnan et al found no correlation between i.v.…”
Section: Discussionmentioning
confidence: 97%
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“…Other groups using the i.v. dGEMRIM approach like Sigurdsson et al found a reverse U‐shaped dGEMRIM patterns at different stages of meniscus lesions with increasing dGEMRIM for the moderate meniscal degenerations degrees that decreased for high grades,, and in a histologic study by Sun et al they found that severe loss of collagen and increasing concentration of proteoglycans were hallmarks of OA degenerated menisci, which is the reverse process of GAG behavior in cartilage. Finally, Krishnan et al found no correlation between i.v.…”
Section: Discussionmentioning
confidence: 97%
“…With this method, the passive diffusion of negatively charged gadolinium (Gd) into cartilage has shown an inverse linear correlation to the amount of GAGs in the articular knee cartilage . Since menisci and cartilage share a collagen matrix and GAG molecules, the same method has been used to study the menisci, called delayed gadolinium‐enhanced MRI of menisci (dGEMRIM) . Even though the amount of GAG is around 1% in the menisci and 5–10% in cartilage, a study by Sigurdsson et al has shown that menisci and cartilage can be examined simultaneously by i.v.…”
mentioning
confidence: 99%
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