Delayed granulomatous reaction and cutaneous fistula induced by retained electrodes from a cardiac pacemaker in a child

Arcos, Leire Sánchez-Los; Feito-Rodríguez, M.; Bandera, Ana Isabel Rodríguez; González-López, G.; Lucas-Laguna, R. de

doi:10.1111/pde.13706

Cited by 5 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This protective response, however, is detrimental to the longterm durability of implantable biomedical devices such as breast implants 5,6 , heart valves 7 , and pacemakers 8 . These devices have transformed modern patient care, but the immune infiltration and fibrotic response can negate device function over time, necessitating painful revision or replacement surgery.…”

mentioning

confidence: 99%

Dynamic actuation enhances transport and extends therapeutic lifespan in an implantable drug delivery platform

et al. 2022

View full text Add to dashboard Cite

Fibrous capsule (FC) formation, secondary to the foreign body response (FBR), impedes molecular transport and is detrimental to the long-term efficacy of implantable drug delivery devices, especially when tunable, temporal control is necessary. We report the development of an implantable mechanotherapeutic drug delivery platform to mitigate and overcome this host immune response using two distinct, yet synergistic soft robotic strategies. Firstly, daily intermittent actuation (cycling at 1 Hz for 5 minutes every 12 hours) preserves long-term, rapid delivery of a model drug (insulin) over 8 weeks of implantation, by mediating local immunomodulation of the cellular FBR and inducing multiphasic temporal FC changes. Secondly, actuation-mediated rapid release of therapy can enhance mass transport and therapeutic effect with tunable, temporal control. In a step towards clinical translation, we utilise a minimally invasive percutaneous approach to implant a scaled-up device in a human cadaveric model. Our soft actuatable platform has potential clinical utility for a variety of indications where transport is affected by fibrosis, such as the management of type 1 diabetes.

show abstract

mentioning

confidence: 99%

Dynamic actuation enhances transport and extends therapeutic lifespan in an implantable drug delivery platform

et al. 2022

View full text Add to dashboard Cite

show abstract

Dealing with the Foreign‐Body Response to Implanted Biomaterials: Strategies and Applications of New Materials

Zhang

Chen

Shi

et al. 2020

Adv Funct Materials

176

139

View full text Add to dashboard Cite

Foreign‐body response caused by implanted biomaterials seriously impedes the function of implants and is a major obstacle to the development of implantable biomaterials and medical devices. Recent advances in implantable biomaterials and medical devices have provided strategies to resist the foreign‐body response. In this review, the mechanism of the foreign‐body response and conventional strategies to mitigate foreign‐body response is briefly introduced. Then, three types of promising foreign‐body response resisting materials are focused and the advantages, characteristics, and applications of each material are discussed. Finally, prospects are put forward for future development of foreign‐body response resisting materials and current challenges that require in‐depth study.

show abstract

Advanced strategies to thwart foreign body response to implantable devices

Capuani

Malgir

Chua

et al. 2022

Bioengineering & Transla Med

View full text Add to dashboard Cite

Mitigating the foreign body response (FBR) to implantable medical devices (IMDs) is critical for successful long‐term clinical deployment. The FBR is an inevitable immunological reaction to IMDs, resulting in inflammation and subsequent fibrotic encapsulation. Excessive fibrosis may impair IMDs function, eventually necessitating retrieval or replacement for continued therapy. Therefore, understanding the implant design parameters and their degree of influence on FBR is pivotal to effective and long lasting IMDs. This review gives an overview of FBR as well as anti‐FBR strategies. Furthermore, we highlight recent advances in biomimetic approaches to resist FBR, focusing on their characteristics and potential biomedical applications.

show abstract

Delayed granulomatous reaction and cutaneous fistula induced by retained electrodes from a cardiac pacemaker in a child

Cited by 5 publications

References 13 publications

Dynamic actuation enhances transport and extends therapeutic lifespan in an implantable drug delivery platform

Dynamic actuation enhances transport and extends therapeutic lifespan in an implantable drug delivery platform

Dealing with the Foreign‐Body Response to Implanted Biomaterials: Strategies and Applications of New Materials

Advanced strategies to thwart foreign body response to implantable devices

Contact Info

Product

Resources

About