Delayed hypersensitivity in Hodgkin's disease

Spectrum of immunodeficiencies with Hodgkin's disease.

“…Protein synthesis (9), mediator production (10), and cytotoxicity (11) by cultured lymphocytes are often subniormiial. Immunodeficiency is expressed in vivo by cutanieous anergy (12,13) and delayed homograft rejection (14). Nevertheless, in vitro abnormalities correlate poorly with clinical aspects of Hodgkin's disease (15).…”

Lymphocyte function in untreated Hodgkin's disease: An important predictor of prognosis

“…untreated patients. Thus, delayed cutanAlong with the successful treatment with eous hypersensitivity to recall antigens intensive radio-and chemotherapy, have (Chase, 1966;Young et al, 1972; Holm come reports of late complications. and to sensitizing agents increased risk of acute myelocytic leu-such as dinitrochlorobenzene (Aisenberg, kaemia (Bonadonna et al, 1973;Canellos 1962;Brown et al, 1967;Eltringham & et al, 1975;Brody & Schottenfeld, 1980) Kaplan, 1973 allograft survival is prolonged (Green & Corso, 1958;Kelly et al, 1958;Miller et al, 1961).…”

Walter Hubert Lecture, delivered 1 April 1980 to the 21st AGM of the BACR Malignant lymphomas as tumours of the immune system

“…shows strong evidence ofa derangement of the T-cell limb of the immune system (Long, 1979). Untreated patients with newly diagnosed and even localized disease may exhibit functionally deficient T-cell-mediated immune responses, such as impaired delayed hypersensitivity (Young et al, 1973) prolonged retention of cutaneous grafts (Kelly et al, 1960), and increased susceptibilitv to certain infectious organisms (Casazza et al, 1966 (Fuks et al, 1976). Also linking H.D.…”

“…to the T-cell system is the often striking preferential localization of tumour within thymic-dependent paracortical regions of partially involved lymph nodes. On the basis of these indirect clues, some investigators have suggested that the Reed-Sternberg cell is a transformed T lymphocyte, perhaps antigenically altered by viral infection (Order & Hellman, 1972;DeVita, 1973;Biniaminov & Ramot, 1974 (Boecker et al, 1975;Kay & Kadin, 1975;Schmitt et al, 1977;Stuart et al, 1977).…”