Delayed Immune-Mediated Adverse Effects of Polyalkylimide Dermal Fillers

Alijotas‐Reig, Jaume; Garcia-Gimenez, Victor; Miró-Mur, Francesc; Vilardell‐Tarrés, Miquel

doi:10.1001/archderm.144.5.637

Cited by 46 publications

(59 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In theory, gradual development of network collagen fibres around the particles appears to coincide with a decrease in the inflammatory reaction, but so-called stable granulomas may evolve into a progressive abnormal granulomatous response to fillers. Sometimes, undesirable effects appear during minor trauma or after infection [1,19,21]. However, in our series of patients, no triggering factors could be detected.…”

Section: Discussionmentioning

confidence: 62%

“…Delayed granulomatous reactions have been related to collagen, silicone, polyalkylimide, polyacrylamide, hyaluronic acid, Gore-Tex® and methacrylate implants [1,5,19,20,21]. The same type of adverse reactions has been described with the use of combinations of methacrylate-collagen and ethylmethacrylate-hyaluronic acid [22].…”

Section: Discussionmentioning

confidence: 99%

“…Antimalarials also have many anti-inflammatory, anti-aggregant and immune-regulatory properties [31]. Cases of granulomatous reactions secondary to implant fillers have been treated with hydroxychloroquine [19,20,22,32]. Allopurinol was administered to 1 patient (case 2).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Late-Onset Immune-Mediated Adverse Effects after Poly-<i>L</i>-Lactic Acid Injection in Non-HIV Patients: Clinical Findings and Long-Term Follow-Up

2009

Self Cite

View full text Add to dashboard Cite

Background: It has been thought that poly-L-lactic acid (PLLA) injections do not have inflammatory side effects. Recent evidence shows that local/regional/systemic delayed adverse effects may appear with its use. Objective: To evaluate the clinical complaints, treatment response and long-term follow-up of non-HIV patients with delayed immune-mediated adverse effects related to PLLA injections. Methods: Prospective, case series study of 10 patients with delayed adverse effects related to PLLA injections. The inclusion criterion was defined as the onset at least 6 months after PLLA use, with 1 or more of the following clinical signs: oedema, skin induration, swelling/tender nodules with or without discharge of pus or filler material. Several systemic manifestations were also included. Patients with immediate side effects were excluded. Patients underwent clinical management and long-term follow-up. Results: The average latency period to the onset of symptoms was 19.2 months (range: 6–60). Tender, inflammatory nodules and facial oedema were commonly seen. One case presented a systemic granulomatous disorder as a complication. After 50.2 months of average follow-up (range: 38–78), 5 patients are in remission, 4 have recurrent bouts and the last case has been lost to follow-up. Conclusion:Although infrequently, local and/or regional and/or systemic delayed and recurrent granulomatous reactions may complicate PLLA gel injections.

show abstract

Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Late-Onset Immune-Mediated Adverse Effects after Poly-<i>L</i>-Lactic Acid Injection in Non-HIV Patients: Clinical Findings and Long-Term Follow-Up

2009

Self Cite

View full text Add to dashboard Cite

show abstract

“…Aunque todos deberían ser farmacológicamente inertes y no inmunogénicos, están descritas reacciones adversas a corto y medio plazo y también se empiezan a describir reacciones adversas tardías, no sólo a nivel focal, sino incluso a nivel sistémico (12).…”

Section: Discussionunclassified

“…e) Migración del material: es más probable con materiales que se coleccionan en vacuolas y que poseen poca difusión hacia el medio que los rodea. Aunque puede suceder con la SIL cuando se administraba en forma de bolos, es típica su migración hacia las partes declives de la cara tras la corrección de surcos nasogenianos o de labios (12). En el caso de PAI de polialquimida, las maniobras de extracción o limpieza dental activan la inflamación y alteran incluso la estabilidad de un material de relleno que puede llevar varios años implantado.…”

Section: Efectos Adversosunclassified

Ecografía de los materiales de relleno inyectables y su interés en el seguimiento diagnóstico

Cabo-Francés¹,

Alcolea²,

Bové-Farré

et al. 2012

Cir. plást. iberolatinoam.

View full text Add to dashboard Cite

ResumenEl objetivo de este artículo es ayudar a la identificación de los materiales de relleno inyectables, interpretando los diversos patrones ecográficos sistematizados según las zonas y planos cutáneos en los que se localizan. En la mayoría de los casos, los propios pacientes desconocen el tipo de material que se les ha infiltrado. Para el médico es importante conocer su procedencia y características, ya que aunque no haya problemas, con el paso del tiempo pueden requerirse nuevas inyecciones de otros materiales, lo que exige saber las posibles incompatibilidades que pueden surgir por la interacción de un material y otro. La ecografía es una técnica no invasiva, reproducible, que permite seguir la evolución en el tiempo de estos materiales y clasificarlos según patrones identificables. Su práctica es relativamente fácil y resulta de ayuda tanto para el médico que realiza estas técnicas como para otros especialistas que ven en sus consultas a este tipo de pacientes. Palabras clave Materiales inyectables,Rellenos faciales, Rellenos corporales, Complicaciones, Ecografía. Código numérico 266-140 AbstractThe aim of this paper it to help to identify injected fillers by interpreting the different ultrasound patterns that we have systemized depending on the areas and cutaneous planes where they are located. Most of the patients don't know the filler has been injected. For doctors it's important to know the origin and characteristics of the product because even without complications, over time new injections with different products may be necessary and it's important to know any incompatibilities that may occur if one product negatively interacts with another. The ultrasound is a reproducible and non invasive technique that allows follow-up of the filler and to classify it in identifiable patterns. This practice is relatively easy to carry out and is of great help for doctors who use fillers or for those other specialist who review these patients.

show abstract

Delayed Inflammatory Reaction to Bio-Alcamid Polyacrylamide Gel Used for Soft-Tissue Augmentation

Chrastil-LaTowsky¹,

Wesley²,

MacGregor³

et al. 2009

Arch Dermatol

View full text Add to dashboard Cite

Background: Given the recent boom of the cosmetic industry, there is a wealth of new products available to patients and physicians, including soft-tissue fillers. Bio-Alcamid polyacrylamide gel (Polymekon, Milan, Italy) is a filler that has potential to cause adverse reactions. Observations: Two patients who had previously been treated with Bio-Alcamid outside of the United States presented with different manifestations of inflammatory responses to the product. These reactions were challenging to treat. Conclusions: Despite claims of safety, Bio-Alcamid and possibly other soft-tissue fillers available worldwide have the potential to cause adverse reactions. Physicians should be aware of the various presentations and treatment options for these reactions.

show abstract

Delayed Immune-Mediated Adverse Effects of Polyalkylimide Dermal Fillers

Cited by 46 publications

References 39 publications

Late-Onset Immune-Mediated Adverse Effects after Poly-<i>L</i>-Lactic Acid Injection in Non-HIV Patients: Clinical Findings and Long-Term Follow-Up

Late-Onset Immune-Mediated Adverse Effects after Poly-<i>L</i>-Lactic Acid Injection in Non-HIV Patients: Clinical Findings and Long-Term Follow-Up

Ecografía de los materiales de relleno inyectables y su interés en el seguimiento diagnóstico

Delayed Inflammatory Reaction to Bio-Alcamid Polyacrylamide Gel Used for Soft-Tissue Augmentation

Contact Info

Product

Resources

About