Delayed Immunomodulatory Effect of Cow Milk–Free Diet in Ménière's Disease

Berardino, Federica Di; Zanetti, Diego

doi:10.1080/07315724.2017.1364181

Cited by 7 publications

(3 citation statements)

References 19 publications

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“…Of note, there is a trend to specifically select a treatment to block the generation of endolymphatic hydrops by analyzing the causes of endolymphatic hydrops ( 15 ). Immunotherapy have been widely used for the treatment of tumors ( 16 , 17 ) and have been documented to be beneficial in controlling the symptoms in patients with MD ( 18 , 19 ). However, to the best of our knowledge, no previous study exist that clearly addressed the mechanism of action and efficacy of immunosuppressants in MD.…”

Section: Introductionmentioning

confidence: 99%

Cyclophosphamide inhibits the progression of Meniere's disease by reducing the generation of circulating immune complex

Zhang

Gong

et al. 2021

Exp Ther Med

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Endolymphatic hydrops is a characteristic pathological manifestation of Meniere's disease (MD) that has been previously associated with autoimmunity. Interest in the circulating immune complex (CIC) has increased due to its reported role in the occurrence of MD. The present study aimed to investigate the potential value of serum CIC concentration in the diagnosis of MD and the therapeutic potential of cyclophosphamide (CTX) for the treatment of MD. In the present study, guinea pigs were immunized with isologous crude inner ear antigens to establish an autoimmune MD model. Pure tone audiometry, Vestibular-evoked myogenic potential test, electrocochleography test and auditory brainstem response was applied in this study for assessing the severity of MD in guinea pigs. ELISA was applied to measure CIC, tumor necrosis factor α (TNF-α) and heat shock protein 70 (HSP70) expression levels in the serum samples of different groups of patients. Western blotting was applied to detect the protein expression of HSP70 in inner ear tissues in guinea pigs. Hematoxylin and eosin staining was applied to visualize the spiral ganglions in spiral ganglions models. CIC expression in the inner ear was detected by immunohistochemistry. In vivo experiments were performed to confirm the therapeutic effects of CTX in MD. Serum concentrations of CIC, TNF-α and HSP70 were found to be significantly higher in patients with MD, which were also associated with increases in hearing classification and the severity of endolymphatic hydrops. Using a guinea pig MD model, ELISA results revealed significantly increased serum CIC, TNF-α and HSP70 concentrations compared with those in the control group. ABR results showed that the thresholds in the CTX group were notably decreased compared with that in the dexamethasone group, whereas CIC concentrations in the serum were reduced following dexamethasone and CTX treatments compared with those after saline treatment. In the inner ear tissues, the CIC concentration in CTX group was lower than that in the dexamethasone group. Similarly, reductions in HSP70 and TNF-α concentrations was also observed in a similar manner. Immunohistochemistry staining found notably lower CIC deposition in the inner ear tissues following CTX treatment than that in dexamethasone group. Taken together, higher CIC expression can be used as a biomarker for MD diagnosis. The efficacy of CTX in MD was found to be higher compared with that in dexamethasone, which may be associated with the effective inhibition of CIC, HSP70 and TNF-α generation.

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Section: Introductionmentioning

confidence: 99%

Cyclophosphamide inhibits the progression of Meniere's disease by reducing the generation of circulating immune complex

Zhang

Gong

et al. 2021

Exp Ther Med

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“…In 1923, inhalant and food allergies have been related to Ménières’ disease (MD) [1]; from then until now, this relation has been reported in the literature [2–7]. Since 2013, increased intestinal permeability has been shown to be an intrinsic trait in a subset of food allergic subjects [8, 9].…”

Section: Introductionmentioning

confidence: 99%

Increased urinary volumes in symptomatic Ménière’s Disease

Berardino

Zanetti

2019

BMC Res Notes

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ObjectiveThe purpose of the research is to test the measurement of the total urinary volume, induced by the diuretic osmotic action of mannitol, in a group of symptomatic MD patients and in healthy controls.ResultsAn altered excretory urinary volume after mannitol challenge was observed in symptomatic MD (874.3 ± 302.1) compared to healthy volunteers (361.7 ± 181.6) (p = 0.0001). This easy and self-administered method might be proposed to replace the analysis of the urinary sugars’ concentration in symptomatic MD patients.

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“…In 1923, inhalant and food allergies have been related to Ménières' disease (MD); [1] from then until now, this relation has been reported in the literature. [2][3][4][5][6][7] Since 2013, increased intestinal permeability has been shown to be an intrinsic trait in a subset of food allergic subjects. [8,9] The urinary excretion of two orally administered non-metabolizable sugars, lactulose and mannitol, also known as the "double sugar test" is a well-known, validated, non-invasive method to evaluate the intestinal permeability, because their urinary concentration is an indirect index of their intestinal absorption.…”

Section: Introductionmentioning

confidence: 99%

Increased urinary volumes in symptomatic Ménière’s Disease

Berardino

Zanetti

2019

Preprint

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Objective. The purpose of the research is to test the measurement of the total urinary volume, induced by the diuretic osmotic action of mannitol, in a group of symptomatic MD patients and in healthy controls. Results. An altered excretory urinary volume after mannitol challenge was observed in symptomatic MD (874.3 ± 302.1) compared to healthy volunteers (361.7 ± 181.6). (p = 0.0001) This easy and self-administered method might be proposed to replace the analysis of the urinary sugars' concentration in symptomatic MD patients.

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Delayed Immunomodulatory Effect of Cow Milk–Free Diet in Ménière's Disease

Abstract: The effect of dietary modification was evident only after specific immunotherapies against other allergens. This highlights the importance of evaluating different combinations of defined causative elements in the allergic treatment of MD.

Cited by 7 publications

References 19 publications

Cyclophosphamide inhibits the progression of Meniere's disease by reducing the generation of circulating immune complex

Cyclophosphamide inhibits the progression of Meniere's disease by reducing the generation of circulating immune complex

Increased urinary volumes in symptomatic Ménière’s Disease

Increased urinary volumes in symptomatic Ménière’s Disease

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